Active Glutaminase C Self-assembles into a Supratetrameric Oligomer That Can Be Disrupted by an Allosteric Inhibitor
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Structural Basis for the Active Site Inhibition Mechanism of Human Kidney-Type Glutaminase (KGA)Mechanistic Basis of Glutaminase Activation: A KEY ENZYME THAT PROMOTES GLUTAMINE METABOLISM IN CANCER CELLSFrom Krebs to clinic: glutamine metabolism to cancer therapy.Mechanism by which a recently discovered allosteric inhibitor blocks glutamine metabolism in transformed cells.Effect of lysine to alanine mutations on the phosphate activation and BPTES inhibition of glutaminaseTargeted inhibition of tumor-specific glutaminase diminishes cell-autonomous tumorigenesis.Targeting glutaminolysis has antileukemic activity in acute myeloid leukemia and synergizes with BCL-2 inhibitionStructural basis for exploring the allosteric inhibition of human kidney type glutaminase.A tale of two glutaminases: homologous enzymes with distinct roles in tumorigenesis.T Helper Cell Activation and Expansion Is Sensitive to Glutaminase Inhibition under Both Hypoxic and Normoxic Conditions.Glutaminase inhibition in multiple myeloma induces apoptosis via MYC degradation.The origin and evolution of human glutaminases and their atypical C-terminal ankyrin repeats.Glutaminases.Conformational changes in the activation loop of mitochondrial glutaminase C: A direct fluorescence readout that distinguishes the binding of allosteric inhibitors from activators.Inhibition of Glycolysis and Glutaminolysis: Emerging Drug Discovery Approach to Combat Cancer.
P2860
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P2860
Active Glutaminase C Self-assembles into a Supratetrameric Oligomer That Can Be Disrupted by an Allosteric Inhibitor
description
2013 nî lūn-bûn
@nan
2013 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի սեպտեմբերին հրատարակված գիտական հոդված
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2013年の論文
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2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
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2013年论文
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name
Active Glutaminase C Self-asse ...... ted by an Allosteric Inhibitor
@ast
Active Glutaminase C Self-asse ...... ted by an Allosteric Inhibitor
@en
Active Glutaminase C Self-asse ...... ted by an Allosteric Inhibitor
@nl
type
label
Active Glutaminase C Self-asse ...... ted by an Allosteric Inhibitor
@ast
Active Glutaminase C Self-asse ...... ted by an Allosteric Inhibitor
@en
Active Glutaminase C Self-asse ...... ted by an Allosteric Inhibitor
@nl
prefLabel
Active Glutaminase C Self-asse ...... ted by an Allosteric Inhibitor
@ast
Active Glutaminase C Self-asse ...... ted by an Allosteric Inhibitor
@en
Active Glutaminase C Self-asse ...... ted by an Allosteric Inhibitor
@nl
P2093
P2860
P50
P921
P3181
P356
P1476
Active Glutaminase C Self-asse ...... ted by an Allosteric Inhibitor
@en
P2093
Alexandre Cassago
Amanda Petrina Scotá Ferreira
Andre Luis Berteli Ambrosio
Camila Fornezari
Carolline Fernanda Rodrigues Ascenção
Igor Monteze Ferreira
Juliana Ferreira de Oliveira
Kaliandra de Almeida Gonçalves
Marília Meira Dias
Paulo Sérgio Lopes Oliveira
P2860
P304
P3181
P356
10.1074/JBC.M113.501346
P407
P577
2013-09-27T00:00:00Z