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Notch inhibits apoptosis by direct interference with XIAP ubiquitination and degradationDeletion of the RNA-binding proteins ZFP36L1 and ZFP36L2 leads to perturbed thymic development and T lymphoblastic leukemiaIdentification of a conserved negative regulatory sequence that influences the leukemogenic activity of NOTCH1Endothelial Transdifferentiation of Tumor Cells Triggered by the Twist1-Jagged1-KLF4 Axis: Relationship between Cancer Stemness and AngiogenesisRecent advancements of bortezomib in acute lymphocytic leukemia treatmentA dominantly acting murine allele of Mcm4 causes chromosomal abnormalities and promotes tumorigenesisOncogenic Kras initiates leukemia in hematopoietic stem cellsAnalysis of the chronic lymphocytic leukemia coding genome: role of NOTCH1 mutational activation.Therapeutic targeting of the cyclin D3:CDK4/6 complex in T cell leukemia.Zebrafish Models of Human Leukemia: Technological Advances and Mechanistic InsightsAcute T-cell leukemias remain dependent on Notch signaling despite PTEN and INK4A/ARF loss.Genetic and clonal dissection of murine small cell lung carcinoma progression by genome sequencing.NOTCH1 inhibition in vivo results in mammary tumor regression and reduced mammary tumorsphere-forming activity in vitroModeling T-cell acute lymphoblastic leukemia induced by the SCL and LMO1 oncogenes.Identification of novel targets of CSL-dependent Notch signaling in hematopoiesisATM-deficient thymic lymphoma is associated with aberrant tcrd rearrangement and gene amplification.Enhanced Notch activation is advantageous but not essential for T cell lymphomagenesis in Id1 transgenic micePTEN action in leukaemia dictated by the tissue microenvironment.Notch signalling in T-cell lymphoblastic leukaemia/lymphoma and other haematological malignancies.Cyclin C is a haploinsufficient tumour suppressor.Deletion-based mechanisms of Notch1 activation in T-ALL: key roles for RAG recombinase and a conserved internal translational start site in Notch1.Cellular context-dependent effects of H2ax and p53 deletion on the development of thymic lymphoma.NOTCH1 directly regulates c-MYC and activates a feed-forward-loop transcriptional network promoting leukemic cell growthThe evolution of thymic lymphomas in p53 knockout miceFli-1 overexpression in hematopoietic progenitors deregulates T cell development and induces pre-T cell lymphoblastic leukaemia/lymphoma.SCL, LMO1 and Notch1 reprogram thymocytes into self-renewing cellsThe role of Notch signaling pathway in epithelial-mesenchymal transition (EMT) during development and tumor aggressivenessc-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma.Notch3/Jagged1 circuitry reinforces notch signaling and sustains T-ALLConstitutive Notch pathway activation in murine ZMYM2-FGFR1-induced T-cell lymphomas associated with atypical myeloproliferative disease.Identification of 11-amino acid peptides that disrupt Notch-mediated processes in Drosophila.Endogenous oncogenic Nras mutation initiates hematopoietic malignancies in a dose- and cell type-dependent manner.Notch1 contributes to mouse T-cell leukemia by directly inducing the expression of c-mycZEB2 drives immature T-cell lymphoblastic leukaemia development via enhanced tumour-initiating potential and IL-7 receptor signalling.Notch1 inhibition targets the leukemia-initiating cells in a Tal1/Lmo2 mouse model of T-ALL.Repression of Ccr9 transcription in mouse T lymphocyte progenitors by the Notch signaling pathway.Notch Signaling in T-Cell Development and T-ALLCell of origin strongly influences genetic selection in a mouse model of T-ALLSequential mutations in Notch1, Fbxw7, and Tp53 in radiation-induced mouse thymic lymphomas.Clinical and molecular characterization of early T-cell precursor leukemia: a high-risk subgroup in adult T-ALL with a high frequency of FLT3 mutations
P2860
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P2860
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
Activating Notch1 mutations in mouse models of T-ALL.
@ast
Activating Notch1 mutations in mouse models of T-ALL.
@en
type
label
Activating Notch1 mutations in mouse models of T-ALL.
@ast
Activating Notch1 mutations in mouse models of T-ALL.
@en
prefLabel
Activating Notch1 mutations in mouse models of T-ALL.
@ast
Activating Notch1 mutations in mouse models of T-ALL.
@en
P2093
P2860
P1433
P1476
Activating Notch1 mutations in mouse models of T-ALL.
@en
P2093
A Thomas Look
Craig H Bassing
Frederick W Alt
Jennifer Calvo
Jennifer O'Neil
Jon C Aster
Keith McKenna
Michelle Kelliher
Veena Krishnamoorthy
P2860
P304
P356
10.1182/BLOOD-2005-06-2553
P407
P577
2005-09-15T00:00:00Z