Surveillance mechanism linking Bub1 loss to the p53 pathway. - Wikidata - awgldk - TriplyDB

Surveillance mechanism linking Bub1 loss to the p53 pathway.

Surveillance mechanism linking Bub1 loss to the p53 pathway.

http://www.wikidata.org/entity/Q35850149

about

Bub1 regulates chromosome segregation in a kinetochore-independent manner MTBP plays a crucial role in mitotic progression and chromosome segregation Simian virus 40 large T antigen disrupts genome integrity and activates a DNA damage response via Bub1 binding Causes of genome instability: the effect of low dose chemical exposures in modern society p53 isoforms Delta133p53 and p53beta are endogenous regulators of replicative cellular senescence CENP-A reduction induces a p53-dependent cellular senescence response to protect cells from executing defective mitoses.Mechanisms and consequences of aneuploidy and chromosome instability in the aging brain A truncated T antigen expressed from an alternatively spliced BK virus early mRNA.MicroRNA-450a-3p represses cell proliferation and regulates embryo development by regulating Bub1 expression in mouse.Impaired Bub1 function in vivo compromises tension-dependent checkpoint function leading to aneuploidy and tumorigenesis.Identification of potential synthetic lethal genes to p53 using a computational biology approach Cellular transformation by Simian Virus 40 and Murine Polyoma Virus T antigens.Sensors at centrosomes reveal determinants of local separase activity.Transcriptional Profiling of Laser Capture Microdissected Subpopulations of the Osteoblast Lineage Provides Insight Into the Early Response to Sclerostin Antibody in Rats.The role of nuclear lamin B1 in cell proliferation and senescence.Expression profiles of cohesins, shugoshins and spindle assembly checkpoint genes in rhesus macaque oocytes predict their susceptibility for aneuploidy during embryonic development.Potential tumorigenic programs associated with TP53 mutation status reveal role of VEGF pathway Whole chromosome aneuploidy in the brain of Bub1bH/H and Ercc1-/Δ7 mice.p53 regulates a mitotic transcription program and determines ploidy in normal mouse liver Gene expression time-series analysis of camptothecin effects in U87-MG and DBTRG-05 glioblastoma cell lines.Whole Chromosome Instability induces senescence and promotes SASP.How to become immortal: let MEFs count the ways MDM2 binding protein, a novel metastasis suppressor.Ataxia telangiectasia-mutated damage-signaling kinase- and proteasome-dependent destruction of Mre11-Rad50-Nbs1 subunits in Simian virus 40-infected primate cells DNA damage response signaling triggers nuclear localization of the chicken anemia virus protein Apoptin.Molecular characterization of immortalized normal and dysplastic oral cell lines.Dysregulation of hypoxia pathways in fumarate hydratase-deficient cells is independent of defective mitochondrial metabolism.Replication stress and mitotic dysfunction in cells expressing simian virus 40 large T antigen

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P2860

Surveillance mechanism linking Bub1 loss to the p53 pathway.

http://www.wikidata.org/entity/Q35850149

description

2007 nî lūn-bûn

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2007年の論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

@zh-tw

2007年论文

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2007年论文

@zh

2007年论文

@zh-cn

name

Surveillance mechanism linking Bub1 loss to the p53 pathway.

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Surveillance mechanism linking Bub1 loss to the p53 pathway.

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type

label

Surveillance mechanism linking Bub1 loss to the p53 pathway.

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Surveillance mechanism linking Bub1 loss to the p53 pathway.

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prefLabel

Surveillance mechanism linking Bub1 loss to the p53 pathway.

@ast

Surveillance mechanism linking Bub1 loss to the p53 pathway.

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PNAS.0703164104

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Proceedings of the National Academy of Sciences of the United States of America

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Surveillance mechanism linking Bub1 loss to the p53 pathway.

@en

P2093

Brian Schaffhausen

http://www.w3.org/2001/XMLSchema#string

Devin Chandler-Militello

http://www.w3.org/2001/XMLSchema#string

Grace L Williams

http://www.w3.org/2001/XMLSchema#string

Jean Zhao

http://www.w3.org/2001/XMLSchema#string

Jiaping Wu

http://www.w3.org/2001/XMLSchema#string

Ole V Gjoerup

http://www.w3.org/2001/XMLSchema#string

Parmjit S Jat

http://www.w3.org/2001/XMLSchema#string

Thomas M Roberts

http://www.w3.org/2001/XMLSchema#string

P2860

Simian virus 40 large T antigen targets the spindle assembly checkpoint protein Bub1

Phosphorylation of Cdc20 by Bub1 provides a catalytic mechanism for APC/C inhibition by the spindle checkpoint

Bub1 is required for kinetochore localization of BubR1, Cenp-E, Cenp-F and Mad2, and chromosome congression

Mutations of mitotic checkpoint genes in human cancers

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

The p400 E1A-associated protein is a novel component of the p53 --> p21 senescence pathway

Human Bub1 protects centromeric sister-chromatid cohesion through Shugoshin during mitosis

A biomarker that identifies senescent human cells in culture and in aging skin in vivo

Lethality to human cancer cells through massive chromosome loss by inhibition of the mitotic checkpoint.

The Saccharomyces cerevisiae checkpoint gene BUB1 encodes a novel protein kinase

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104

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