Conformational isomerism and the diversity of antibodies
about
Insights into Protein-Ligand Interactions: Mechanisms, Models, and MethodsProtein flexibility in docking and surface mappingHigh affinity antigen recognition of the dual specific variants of herceptin is entropy-driven in spite of structural plasticityRigidification of a Flexible Protease Inhibitor Variant upon Binding to TrypsinMolecular evolution of antibody cross-reactivity for two subtypes of type A botulinum neurotoxinConformational Isomerism Can Limit Antibody CatalysisEnzymes with lid-gated active sites must operate by an induced fit mechanism instead of conformational selectionFollowing evolutionary paths to protein-protein interactions with high affinity and selectivityStructural Analysis of Protein Folding by the Long-Chain Archaeal Chaperone FKBP26Reactibodies generated by kinetic selection couple chemical reactivity with favorable protein dynamicsEssential role of conformational selection in ligand bindingSomatic Hypermutation-Induced Changes in the Structure and Dynamics of HIV-1 Broadly Neutralizing AntibodiesThree quaternary structures for a single proteinThe 2.0-A resolution crystal structure of a trimeric antibody fragment with noncognate VH-VL domain pairs shows a rearrangement of VH CDR3Conformational correction mechanisms aiding antigen recognition by a humanized antibodyMulti-constraint computational design suggests that native sequences of germline antibody H3 loops are nearly optimal for conformational flexibilityThe role of dynamic conformational ensembles in biomolecular recognitionResolution of Site-Specific Conformational Heterogeneity in Proline-Rich Molecular Recognition by Src Homology 3 Domains.Ways and means of coping with uncertainties of the relationship of the genetic blue print to protein structure and function in the cellRecognition of E. coli tryptophan synthase by single-chain Fv fragments: comparison of PCR-cloning variants with the parental antibodies.Structure and kinetics of a transient antibody binding intermediate reveal a kinetic discrimination mechanism in antigen recognition.Sequence-specific binding of normal serum immunoglobulin M to exposed protein C-termini.Cross-reactivity and conformational multiplicity of an anti-polycyclic aromatic hydrocarbon mAbAntibody evolution constrains conformational heterogeneity by tailoring protein dynamics.The acquisition of narrow binding specificity by polyspecific natural IgM antibodies in a semi-physiological environment.Insights into the dynamics of specific telomeric single-stranded DNA recognition by Pot1pNFolding funnels, binding funnels, and protein functionFolding funnels and binding mechanisms.Folding and binding cascades: dynamic landscapes and population shifts.Kinetics of ligand binding to receptor immobilized in a polymer matrix, as detected with an evanescent wave biosensor. I. A computer simulation of the influence of mass transport.Kinetic rate constant prediction supports the conformational selection mechanism of protein binding.Recognition between flexible protein molecules: induced and assisted folding.Differences in electrostatic properties at antibody-antigen binding sites: implications for specificity and cross-reactivity.Structural changes involved in protein binding correlate with intrinsic motions of proteins in the unbound state.Quantitative modeling assesses the contribution of bond strengthening, rebinding and force sharing to the avidity of biomolecule interactions.Evolving concepts of specificity in immune reactionsHuman germline antibody gene segments encode polyspecific antibodies.T cell receptor-ligand interactions: a conformational preequilibrium or an induced fit.Multidisciplinary experimental approaches to characterizing biomolecular dynamics.Kinetic asymmetry of subunit exchange of homooligomeric protein as revealed by deuteration-assisted small-angle neutron scattering.
P2860
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P2860
Conformational isomerism and the diversity of antibodies
description
1994 nî lūn-bûn
@nan
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
1994年论文
@zh
1994年论文
@zh-cn
name
Conformational isomerism and the diversity of antibodies
@ast
Conformational isomerism and the diversity of antibodies
@en
type
label
Conformational isomerism and the diversity of antibodies
@ast
Conformational isomerism and the diversity of antibodies
@en
prefLabel
Conformational isomerism and the diversity of antibodies
@ast
Conformational isomerism and the diversity of antibodies
@en
P2860
P356
P1476
Conformational isomerism and the diversity of antibodies
@en
P2093
P2860
P304
10370-10374
P356
10.1073/PNAS.91.22.10370
P407
P577
1994-10-01T00:00:00Z