Mutation drift and repertoire shift in the maturation of the immune response.
about
IgVH genes from different anatomical regions, with different histopathological patterns, of a rheumatoid arthritis patient suggest cyclic re-entry of mature synovial B-cells in the hypermutation processAID-GFP chimeric protein increases hypermutation of Ig genes with no evidence of nuclear localization.Memory in the B-cell compartment: antibody affinity maturationThe structural basis of repertoire shift in an immune response to phosphocholineInduction of anti-progesterone immunity and pregnancy blocking by anti-progesterone anti-idiotypes. Variable efficacy of polyclonal Ab2 antibodies directed against a panel of closely related Ab1 antibodiesSevere attenuation of the B cell immune response in Msh2-deficient miceNormal induction but attenuated progression of germinal center responses in BAFF and BAFF-R signaling-deficient miceConstruction and characterization of single-chain variable fragment antibody library derived from germline rearranged immunoglobulin variable genesThe lupus-prone NZM2410/NZW strain-derived Sle1b sublocus alters the germinal center checkpoint in female mice in a B cell-intrinsic manner.A central core structure in an antibody variable domain determines antigen specificity.Generation and analysis of random point mutations in an antibody CDR2 sequence: many mutated antibodies lose their ability to bind antigenIn vitro selection and affinity maturation of antibodies from a naive combinatorial immunoglobulin libraryIsolation of an IgG anti-B from a human Fab-phage display library.Deriving a germinal center lymphocyte migration model from two-photon data.Identification of mutant monoclonal antibodies with increased antigen bindingSomatic diversification of the S107 (T15) VH11 germ-line gene that encodes the heavy-chain variable region of antibodies to double-stranded DNA in (NZB x NZW)F1 miceGenetic basis of the antibody repertoire in Xenopus: analysis of the Vh diversity.Optimality of mutation and selection in germinal centers.Molecular analysis of immunoglobulin genes in multiple myeloma.Differentiation of B cells in the nonlymphoid tissue of the synovial membrane of patients with rheumatoid arthritisStructural correlates of high antibody affinity: three engineered amino acid substitutions can increase the affinity of an anti-p-azophenylarsonate antibody 200-foldThe protein-protein interface evolution acts in a similar way to antibody affinity maturation.Hypermutation in bacteria and other cellular systemsProtein evolution on partially correlated landscapes.Sudden appearance of anti-protein IgG1-forming cell precursors early during primary immunizationStructural requirements of the major protective antibody to Haemophilus influenzae type bNeonatal immunity and somatic mutation.Isolation of germinal centerlike events from human spleen RNA. Somatic hypermutation of a clonally related VH6DJH rearrangement expressed with IgM, IgG, and IgA.Modeling and optimization of populations subject to time-dependent mutation.Germ line variable regions that match hypermutated sequences in genes encoding murine anti-hapten antibodies.Murine immune response to Neisseria meningitidis group C capsular polysaccharide: analysis of monoclonal antibodies generated in response to a thymus-independent antigen and a thymus-dependent toxoid conjugate vaccineClonal Progression during the T Cell-Dependent B Cell Antibody Response Depends on the Immunoglobulin DH Gene Segment Repertoire.Immunoglobulin variable region hypermutation in hybrids derived from a pre-B- and a myeloma cell linePerpetuation of immunological memory: a relay hypothesis.Basis for selection of improved carbohydrate-binding single-chain antibodies from synthetic gene librariesSignificant structural and functional change of an antigen-binding site by a distant amino acid substitution: proposal of a structural mechanism.Protein evolution on rugged landscapes.Blocking of pregnancy in mice by immunization with anti-idiotype directed against monoclonal anti-progesterone antibodyA well-differentiated B-cell line is permissive for somatic mutation of a transfected immunoglobulin heavy-chain gene.Kinetic and affinity limits on antibodies produced during immune responses.
P2860
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P2860
Mutation drift and repertoire shift in the maturation of the immune response.
description
1987 nî lūn-bûn
@nan
1987年の論文
@ja
1987年論文
@yue
1987年論文
@zh-hant
1987年論文
@zh-hk
1987年論文
@zh-mo
1987年論文
@zh-tw
1987年论文
@wuu
1987年论文
@zh
1987年论文
@zh-cn
name
Mutation drift and repertoire shift in the maturation of the immune response.
@en
Mutation drift and repertoire shift in the maturation of the immune response.
@nl
type
label
Mutation drift and repertoire shift in the maturation of the immune response.
@en
Mutation drift and repertoire shift in the maturation of the immune response.
@nl
prefLabel
Mutation drift and repertoire shift in the maturation of the immune response.
@en
Mutation drift and repertoire shift in the maturation of the immune response.
@nl
P1476
Mutation drift and repertoire shift in the maturation of the immune response.
@en
P2093
P356
10.1111/J.1600-065X.1987.TB00507.X
P577
1987-04-01T00:00:00Z