11q23 translocations split the "AT-hook" cruciform DNA-binding region and the transcriptional repression domain from the activation domain of the mixed-lineage leukemia (MLL) gene.
about
Cloning of a mammalian transcriptional activator that binds unmethylated CpG motifs and shares a CXXC domain with DNA methyltransferase, human trithorax, and methyl-CpG binding domain protein 1.The human GRAF gene is fused to MLL in a unique t(5;11)(q31;q23) and both alleles are disrupted in three cases of myelodysplastic syndrome/acute myeloid leukemia with a deletion 5qThe nuclear factor SPBP contains different functional domains and stimulates the activity of various transcriptional activatorsProtein interactions of the MLL PHD fingers modulate MLL target gene regulation in human cells.Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expressionIdentification and characterization of the human Set1B histone H3-Lys4 methyltransferase complexCloning of ELL, a gene that fuses to MLL in a t(11;19)(q23;p13.1) in acute myeloid leukemiaThe t(10;11)(p13;q14) in the U937 cell line results in the fusion of the AF10 gene and CALM, encoding a new member of the AP-3 clathrin assembly protein familyMolecular cloning and characterization of TIEG2 reveals a new subfamily of transforming growth factor-beta-inducible Sp1-like zinc finger-encoding genes involved in the regulation of cell growthIsolation and characterization of a novel epithelium-specific transcription factor, ESE-1, a member of the ets familyNew insight into the molecular mechanisms of MLL-associated leukemiaThe MLL fusion gene, MLL-AF4, regulates cyclin-dependent kinase inhibitor CDKN1B (p27kip1) expressionProteolytic cleavage of MLL generates a complex of N- and C-terminal fragments that confers protein stability and subnuclear localizationCpG binding protein is crucial for early embryonic developmentMLL and CREB bind cooperatively to the nuclear coactivator CREB-binding proteinActive repression of methylated genes by the chromosomal protein MBD1Involvement of a human gene related to the Drosophila spen gene in the recurrent t(1;22) translocation of acute megakaryocytic leukemiaMbd1 is recruited to both methylated and nonmethylated CpGs via distinct DNA binding domainsHoxa9 and Meis1 are key targets for MLL-ENL-mediated cellular immortalizationIdentification and characterization of the ARP1 gene, a target for the human acute leukemia ALL1 geneHMGI(Y) activation by chromosome 6p21 rearrangements in multilineage mesenchymal cells from pulmonary hamartomaMLL repression domain interacts with histone deacetylases, the polycomb group proteins HPC2 and BMI-1, and the corepressor C-terminal-binding proteinTargeting histone methylation for cancer therapy: enzymes, inhibitors, biological activity and perspectivesHijacked in cancer: the KMT2 (MLL) family of methyltransferasesThe PHD3 domain of MLL acts as a CYP33-regulated switch between MLL-mediated activation and repression .Potent inhibition of DOT1L as treatment of MLL-fusion leukemiaSET1, a yeast member of the trithorax family, functions in transcriptional silencing and diverse cellular processes.Repression of human fibroblast growth factor 2 by a novel transcription factorCooperativity in transcription factor binding to the coactivator CREB-binding protein (CBP). The mixed lineage leukemia protein (MLL) activation domain binds to an allosteric site on the KIX domainHRX leukemic fusion proteins form a heterocomplex with the leukemia-associated protein SET and protein phosphatase 2AA SALL4/MLL/HOXA9 pathway in murine and human myeloid leukemogenesisKRAB-independent suppression of neoplastic cell growth by the novel zinc finger transcription factor KS1Functional specificity of CpG DNA-binding CXXC domains in mixed lineage leukemia.MLL protects CpG clusters from methylation within the Hoxa9 gene, maintaining transcript expression.GPHN, a novel partner gene fused to MLL in a leukemia with t(11;14)(q23;q24).Domains with transcriptional regulatory activity within the ALL1 and AF4 proteins involved in acute leukemia.Selective killing of mixed lineage leukemia cells by a potent small-molecule DOT1L inhibitor.Reduced genomic cytosine methylation and defective cellular differentiation in embryonic stem cells lacking CpG binding protein.Promoter hypermethylation in MLL-r infant acute lymphoblastic leukemia: biology and therapeutic targeting.Trithorax- and Polycomb-group response elements within an Ultrabithorax transcription maintenance unit consist of closely situated but separable sequences.
P2860
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P2860
11q23 translocations split the "AT-hook" cruciform DNA-binding region and the transcriptional repression domain from the activation domain of the mixed-lineage leukemia (MLL) gene.
description
1994 nî lūn-bûn
@nan
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
1994年论文
@zh
1994年论文
@zh-cn
name
11q23 translocations split the ...... d-lineage leukemia (MLL) gene.
@ast
11q23 translocations split the ...... d-lineage leukemia (MLL) gene.
@en
type
label
11q23 translocations split the ...... d-lineage leukemia (MLL) gene.
@ast
11q23 translocations split the ...... d-lineage leukemia (MLL) gene.
@en
prefLabel
11q23 translocations split the ...... d-lineage leukemia (MLL) gene.
@ast
11q23 translocations split the ...... d-lineage leukemia (MLL) gene.
@en
P2093
P2860
P356
P1476
11q23 translocations split the ...... d-lineage leukemia (MLL) gene.
@en
P2093
A M Harden
J D Rowley
N J Zeleznik-Le
P2860
P304
10610-10614
P356
10.1073/PNAS.91.22.10610
P407
P577
1994-10-01T00:00:00Z