about
p21-Activated kinase 1 (Pak1) phosphorylates BAD directly at serine 111 in vitro and indirectly through Raf-1 at serine 112Spatiotemporal regulation of the kinase Mst1 by binding protein RAPL is critical for lymphocyte polarity and adhesionPhosphorylation of caspase-7 by p21-activated protein kinase (PAK) 2 inhibits chemotherapeutic drug-induced apoptosis of breast cancer cell linesHuntingtin promotes cell survival by preventing Pak2 cleavageActivation loop phosphorylation of ERK3/ERK4 by group I p21-activated kinases (PAKs) defines a novel PAK-ERK3/4-MAPK-activated protein kinase 5 signaling pathwayNucleocytoplasmic shuttling of Pak5 regulates its antiapoptotic propertiesRegulation of the Postsynaptic Compartment of Excitatory Synapses by the Actin Cytoskeleton in Health and Its Disruption in DiseaseHistone demethylase KDM4B regulates otic vesicle invagination via epigenetic control of Dlx3 expression.Substance P induces rapid and transient membrane blebbing in U373MG cells in a p21-activated kinase-dependent mannerp21-Activated Kinase 2 Regulates Endothelial Development and Function through the Bmk1/Erk5 PathwayModulation of sterol homeostasis by the Cdc42p effectors Cla4p and Ste20p in the yeast Saccharomyces cerevisiae.A mechanism for the coordination of proliferation and differentiation by spatial regulation of Fus2p in budding yeast.The p21-activated protein kinase inhibitor Skb15 and its budding yeast homologue are 60S ribosome assembly factors.Homologues of oxysterol-binding proteins affect Cdc42p- and Rho1p-mediated cell polarization in Saccharomyces cerevisiae.The Cdc42 effectors Ste20, Cla4, and Skm1 down-regulate the expression of genes involved in sterol uptake by a mitogen-activated protein kinase-independent pathway.Signaling, Regulation, and Specificity of the Type II p21-activated KinasesUpregulation of p21-activated Kinase 6 in rat brain cortex after traumatic brain injuryPAK thread from amoeba to mammalsPAK1 is a novel cardiac protective signaling moleculePAK as a therapeutic target in gastric cancerThe multifunctional GIT family of proteinsDlx transcription factors promote migration through repression of axon and dendrite growthPAK signalling during the development and progression of cancerA mutation in mouse Pak1ip1 causes orofacial clefting while human PAK1IP1 maps to 6p24 translocation breaking points associated with orofacial cleftingp21-activated kinase 1 participates in vascular remodeling in vitro and in vivoDissecting activation of the PAK1 kinase at protrusions in living cells.Identification of two tyrosine residues required for the intramolecular mechanism implicated in GIT1 activation.The role of p21-activated kinase in the initiation of atherosclerosis.Matrix-specific protein kinase A signaling regulates p21-activated kinase activation by flow in endothelial cellsA Rac-cGMP signaling pathway.PAK1-mediated activation of ERK1/2 regulates lamellipodial dynamics.Pak3 inhibits local actin filament formation to regulate global cell polarity.The Rac GTPase effector p21-activated kinase is essential for hematopoietic stem/progenitor cell migration and engraftment.Induction of focal adhesions and motility in Drosophila S2 cellsCdk1 phosphorylates the Rac activator Tiam1 to activate centrosomal Pak and promote mitotic spindle formation.A vertebrate-specific Chp-PAK-PIX pathway maintains E-cadherin at adherens junctions during zebrafish epiboly.Pak2 is required for actin cytoskeleton remodeling, TCR signaling, and normal thymocyte development and maturation.p21-Activated kinases are required for transformation in a cell-based model of neurofibromatosis type 2.A Rac-Pak signaling pathway is essential for ErbB2-mediated transformation of human breast epithelial cancer cells.Tgf-beta induced Erk phosphorylation of smad linker region regulates smad signaling.
P2860
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P2860
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
The genetics of Pak.
@ast
The genetics of Pak.
@en
type
label
The genetics of Pak.
@ast
The genetics of Pak.
@en
prefLabel
The genetics of Pak.
@ast
The genetics of Pak.
@en
P356
P1476
The genetics of Pak.
@en
P2093
Clemens Hofmann
Mikhail Shepelev
P304
P356
10.1242/JCS.01392
P407
P577
2004-09-01T00:00:00Z