Molecular mechanisms of indirubin and its derivatives: novel anticancer molecules with their origin in traditional Chinese phytomedicine.
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Indirubin and Indirubin Derivatives for Counteracting Proliferative DiseasesAn indirubin derivative, indirubin-3'-monoxime suppresses oral cancer tumorigenesis through the downregulation of survivinNew Perspectives on How to Discover Drugs from Herbal Medicines: CAM's Outstanding Contribution to Modern Therapeutics.MS-1020 is a novel small molecule that selectively inhibits JAK3 activity.The continuing search for antitumor agents from higher plantsPotential of plant-derived natural products in the treatment of leukemia and lymphomaThe small molecule indirubin-3'-oxime activates Wnt/β-catenin signaling and inhibits adipocyte differentiation and obesity.6-Bromoindirubin-3'-oxime inhibits JAK/STAT3 signaling and induces apoptosis of human melanoma cells.Dietary ligands of the aryl hydrocarbon receptor induce anti-inflammatory and immunoregulatory effects on murine dendritic cells.Characterization of a flavin-containing monooxygenase from Corynebacterium glutamicum and its application to production of indigo and indirubin.Biological screening of natural products and drug innovation in China.Purified brominated indole derivatives from Dicathais orbita induce apoptosis and cell cycle arrest in colorectal cancer cell lines.Modulating polo-like kinase 1 as a means for cancer chemopreventionMethylisoindigo preferentially kills cancer stem cells by interfering cell metabolism via inhibition of LKB1 and activation of AMPK in PDACs.The Role of Indirubins in Inflammation and Associated Tumorigenesis.The nontoxic cell cycle modulator indirubin augments transduction of adeno-associated viral vectors and zinc-finger nuclease-mediated gene targeting.Indirubin derivatives induce apoptosis of chronic myelogenous leukemia cells involving inhibition of Stat5 signaling.Indirubin-3-monoxime exhibits anti-inflammatory properties by down-regulating NF-κB and JNK signaling pathways in lipopolysaccharide-treated RAW264.7 cells.Immunostimulatory and cytotoxic activities of Indigofera suffruticosa (Fabaceae).Indirubin derivatives inhibit malignant lymphoid cell proliferation.Indirubin enhances tumor necrosis factor-induced apoptosis through modulation of nuclear factor-kappa B signaling pathway.Indirubin improves antioxidant and anti-inflammatory functions in lipopolysaccharide-challenged mice.Improved oral bioavailability of poorly water-soluble indirubin by a supersaturatable self-microemulsifying drug delivery system.Indirubin, a Chinese anti-leukaemia drug, promotes neutrophilic differentiation of human myelocytic leukaemia HL-60 cells.Indirubin Derivative 7-Bromoindirubin-3-Oxime (7Bio) Attenuates Aβ Oligomer-Induced Cognitive Impairments in Mice.Indirubin-3-Oxime Prevents H2O2-Induced Neuronal Apoptosis via Concurrently Inhibiting GSK3β and the ERK Pathway.Identification and characterization of an indigo-producing oxygenase involved in indole 3-acetic acid utilization by Acinetobacter baumannii.The antitumor activity of meisoindigo against human colorectal cancer HT-29 cells in vitro and in vivo.Indirubin, a Constituent of the Chinese Herbal Medicine Qing-Dai, Attenuates Dextran Sulfate Sodium-induced Murine Colitis.Indirubin suppresses ovarian cancer cell viabilities through the STAT3 signaling pathwayMetal Compounds as Kinase and Phosphatase Inhibitors in Drug Development: The Role of the Metal and LigandsIn vitro and in vivo evaluations of the performance of an indirubin derivative, formulated in four different self-emulsifying drug delivery systemsAbsorption Characteristics of Combination Medication of Realgar and : Transport across MDCK-MDR1 Cells and Pharmacokinetics in Mice after Oral AdministrationSystematic pharmacological screens uncover novel pathways involved in cerebral cavernous malformations
P2860
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P2860
Molecular mechanisms of indirubin and its derivatives: novel anticancer molecules with their origin in traditional Chinese phytomedicine.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
2004年论文
@zh
2004年论文
@zh-cn
name
Molecular mechanisms of indiru ...... itional Chinese phytomedicine.
@ast
Molecular mechanisms of indiru ...... itional Chinese phytomedicine.
@en
type
label
Molecular mechanisms of indiru ...... itional Chinese phytomedicine.
@ast
Molecular mechanisms of indiru ...... itional Chinese phytomedicine.
@en
prefLabel
Molecular mechanisms of indiru ...... itional Chinese phytomedicine.
@ast
Molecular mechanisms of indiru ...... itional Chinese phytomedicine.
@en
P2093
P1476
Molecular mechanisms of indiru ...... itional Chinese phytomedicine.
@en
P2093
Frankie Hippe
Sandra Jakobs
Stephan Muehlbeyer
P2888
P304
P356
10.1007/S00432-004-0579-2
P577
2004-08-31T00:00:00Z