about
Intracellular localization of 7-benzylamino-6-chloro-2-piperazino-4-pyrrolidino-pteridine in membrane structures impeding the inhibition of cytosolic cyclic AMP-specific phosphodiesterase.Inhibitors of Leishmania mexicana CRK3 cyclin-dependent kinase: chemical library screen and antileishmanial activity.Indirubin derivatives inhibit Stat3 signaling and induce apoptosis in human cancer cells.Microbial food cultures--opinion of the Senate Commission on Food Safety (SKLM) of the German Research Foundation (DFG).Molecular mechanisms of indirubin and its derivatives: novel anticancer molecules with their origin in traditional Chinese phytomedicine.Dual inhibition of Janus and Src family kinases by novel indirubin derivative blocks constitutively-activated Stat3 signaling associated with apoptosis of human pancreatic cancer cells.Nitrate and nitrite in the diet: how to assess their benefit and risk for human health.Identification of a Water-Soluble Indirubin Derivative as Potent Inhibitor of Insulin-like Growth Factor 1 Receptor through Structural Modification of the Parent Natural Molecule.Methylisoindigo preferentially kills cancer stem cells by interfering cell metabolism via inhibition of LKB1 and activation of AMPK in PDACs.Assessing the potential impact on the thyroid axis of environmentally relevant food constituents/contaminants in humans.7,7'-Diazaindirubin--a small molecule inhibitor of casein kinase 2 in vitro and in cells.Physicochemical characterization and in vitro permeation of an indirubin derivative.Synthesis, topoisomerase-targeting activity and growth inhibition of lycobetaine analogs.Indirubin derivatives induce apoptosis of chronic myelogenous leukemia cells involving inhibition of Stat5 signaling.Dicofol degradation to p,p'-dichlorobenzophenone - a potential antiandrogen.Synthesis and cytotoxicity of novel indirubin-5-carboxamides.Formation of hydrogen peroxide in cell culture media by apple polyphenols and its effect on antioxidant biomarkers in the colon cell line HT-29.Genotoxicity of glycidamide in comparison to 3-N-nitroso-oxazolidin-2-one.Antioxidant effectiveness of phenolic apple juice extracts and their gut fermentation products in the human colon carcinoma cell line caco-2.Genotoxicity of glycidamide in comparison to (+/-)-anti-benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide and alpha-acetoxy-N-nitroso-diethanolamine in human blood and in mammalian V79-cells.Modulation of oxidative cell damage by reconstituted mixtures of phenolic apple juice extracts in human colon cell lines.Acrylamide and glycidamide: approach towards risk assessment based on biomarker guided dosimetry of genotoxic/mutagenic effects in human blood.Differential phosphodiesterase expression and cytosolic Ca2+ in human CNS tumour cells and in non-malignant and malignant cells of rat origin.Acrylamide and glycidamide: genotoxic effects in V79-cells and human blood.Ochratoxin A: induction of (oxidative) DNA damage, cytotoxicity and apoptosis in mammalian cell lines and primary cells.7-Benzylamino-6-chloro-2-piperazino-4-pyrrolidino-pteridine, a potent inhibitor of cAMP-specific phosphodiesterase, enhancing nuclear protein binding to the CRE consensus sequence in human tumour cells.Antioxidant effectiveness of coffee extracts and selected constituents in cell-free systems and human colon cell lines.Synthesis of N-acetyl-S-(3-coumarinyl)-cysteine methyl ester and HPLC analysis of urinary coumarin metabolites.Toxicokinetics of acrylamide in primary rat hepatocytes: coupling to glutathione is faster than conversion to glycidamide.Enhancement of oral bioavailability of E804 by self-nanoemulsifying drug delivery system (SNEDDS) in rats.Binding of the potential antitumour agent indirubin-5-sulphonate at the inhibitor site of rabbit muscle glycogen phosphorylase b. Comparison with ligand binding to pCDK2-cyclin A complex.Sensitive in vitro test systems to determine androgenic/antiandrogenic activity.Effects of hemodialysis, dialyser type and iron infusion on oxidative stress in uremic patients.Inhibition of GSK3beta by indirubins restores HIF-1alpha accumulation under prolonged periods of hypoxia/anoxia.From the insoluble dye indirubin towards highly active, soluble CDK2-inhibitors.Update of the toxicological assessment of furanocoumarins in foodstuffs (Update of the SKLM statement of 23/24 September 2004)--Opinion of the Senate Commission on Food Safety (SKLM) of the German Research Foundation (DFG).In vivo role of cytochrome P450 2E1 and glutathione-S-transferase activity for acrylamide toxicokinetics in humans.Anthocyanin/polyphenolic-rich fruit juice reduces oxidative cell damage in an intervention study with patients on hemodialysis.Fate of 14C-acrylamide in roasted and ground coffee during storage.Biological effects of acrylamide after daily ingestion of various foods in comparison to water: a study in rats.
P50
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P50
name
Gerhard Eisenbrand
@ast
Gerhard Eisenbrand
@en
Gerhard Eisenbrand
@nl
type
label
Gerhard Eisenbrand
@ast
Gerhard Eisenbrand
@en
Gerhard Eisenbrand
@nl
prefLabel
Gerhard Eisenbrand
@ast
Gerhard Eisenbrand
@en
Gerhard Eisenbrand
@nl