Mutations in type 3 reovirus that determine binding to sialic acid are contained in the fibrous tail domain of viral attachment protein sigma1.
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Synergistic antitumor activity of oncolytic reovirus and chemotherapeutic agents in non-small cell lung cancer cellsPotential for Improving Potency and Specificity of Reovirus Oncolysis with Next-Generation Reovirus VariantsCrystal structure of reovirus attachment protein sigma1 reveals evolutionary relationship to adenovirus fiberCrystal structure of human junctional adhesion molecule 1: Implications for reovirus bindingStructure of Reovirus σ1 in Complex with Its Receptor Junctional Adhesion Molecule-ACrystal Structure of Reovirus Attachment Protein σ1 in Complex with Sialylated OligosaccharidesReverse genetics for mammalian reovirus.Cleavage susceptibility of reovirus attachment protein sigma1 during proteolytic disassembly of virions is determined by a sequence polymorphism in the sigma1 neck.Reovirus growth in cell culture does not require the full complement of viral proteins: identification of a sigma1s-null mutant.Reovirus-induced G(2)/M cell cycle arrest requires sigma1s and occurs in the absence of apoptosis.Reovirus binding to cell surface sialic acid potentiates virus-induced apoptosisA monoclonal antibody specific for reovirus outer-capsid protein sigma3 inhibits sigma1-mediated hemagglutination by steric hindrance.Reovirus-induced sigma1s-dependent G(2)/M phase cell cycle arrest is associated with inhibition of p34(cdc2).Identification of carbohydrate-binding domains in the attachment proteins of type 1 and type 3 reovirusesReovirus variants selected for resistance to ammonium chloride have mutations in viral outer-capsid protein sigma3.Sequential partially overlapping gene arrangement in the tricistronic S1 genome segments of avian reovirus and Nelson Bay reovirus: implications for translation initiationIsolation of reovirus T3D mutants capable of infecting human tumor cells independent of junction adhesion molecule-A.Attenuated reovirus displays oncolysis with reduced host toxicitySequence analysis of the genome of piscine orthoreovirus (PRV) associated with heart and skeletal muscle inflammation (HSMI) in Atlantic salmon (Salmo salar).Oncolytic reovirus in canine mast cell tumor.Utilization of sialic acid as a coreceptor is required for reovirus-induced biliary diseaseThe viral sigma1 protein and glycoconjugates containing alpha2-3-linked sialic acid are involved in type 1 reovirus adherence to M cell apical surfaces.Homotrimeric, beta-stranded viral adhesins and tail proteinsGlycan engagement dictates hydrocephalus induction by serotype 1 reovirus.Reovirus receptors and pathogenesis.T-cell-biased immune responses generated by a mucosally targeted adenovirus-σ1 vaccineMechanisms of reovirus-induced cell death and tissue injury: role of apoptosis and virus-induced perturbation of host-cell signaling and transcription factor activation.A mosaic fiber adenovirus serotype 5 vector containing reovirus sigma 1 and adenovirus serotype 3 knob fibers increases transduction in an ovarian cancer ex vivo system via a coxsackie and adenovirus receptor-independent pathwayFrom touchdown to transcription: the reovirus cell entry pathwayReovirus receptors, cell entry, and proapoptotic signaling.NPXY motifs in the beta1 integrin cytoplasmic tail are required for functional reovirus entry.The sweet spot: defining virus-sialic acid interactions.A chimeric adenovirus vector encoding reovirus attachment protein sigma1 targets cells expressing junctional adhesion molecule 1.Junctional adhesion molecule a serves as a receptor for prototype and field-isolate strains of mammalian reovirus.Tropism-modification strategies for targeted gene delivery using adenoviral vectors.Reduction of virion-associated σ1 fibers on oncolytic reovirus variants promotes adaptation toward tumorigenic cells.Amino acids 78 and 79 of Mammalian Orthoreovirus protein µNS are necessary for stress granule localization, core protein λ2 interaction, and de novo virus replication.Nonstructural protein σ1s mediates reovirus-induced cell cycle arrest and apoptosis.Complete in vitro assembly of the reovirus outer capsid produces highly infectious particles suitable for genetic studies of the receptor-binding protein.Protective immunoglobulin A and G antibodies bind to overlapping intersubunit epitopes in the head domain of type 1 reovirus adhesin sigma1.
P2860
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P2860
Mutations in type 3 reovirus that determine binding to sialic acid are contained in the fibrous tail domain of viral attachment protein sigma1.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
1997年论文
@zh
1997年论文
@zh-cn
name
Mutations in type 3 reovirus t ...... ral attachment protein sigma1.
@ast
Mutations in type 3 reovirus t ...... ral attachment protein sigma1.
@en
type
label
Mutations in type 3 reovirus t ...... ral attachment protein sigma1.
@ast
Mutations in type 3 reovirus t ...... ral attachment protein sigma1.
@en
prefLabel
Mutations in type 3 reovirus t ...... ral attachment protein sigma1.
@ast
Mutations in type 3 reovirus t ...... ral attachment protein sigma1.
@en
P2093
P2860
P1433
P1476
Mutations in type 3 reovirus t ...... iral attachment protein sigma1
@en
P2093
J D Chappell
J D Wetzel
T S Dermody
P2860
P304
P407
P577
1997-03-01T00:00:00Z