Infectious subvirion particles of reovirus type 3 Dearing exhibit a loss in infectivity and contain a cleaved sigma 1 protein
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Potential for Improving Potency and Specificity of Reovirus Oncolysis with Next-Generation Reovirus VariantsDiminished reovirus capsid stability alters disease pathogenesis and littermate transmissionStructure of the reovirus outer capsid and dsRNA-binding protein sigma3 at 1.8 A resolution.Crystal structure of reovirus attachment protein sigma1 reveals evolutionary relationship to adenovirus fiberThe GM2 Glycan Serves as a Functional Coreceptor for Serotype 1 ReovirusDeterminants of strain-specific differences in efficiency of reovirus entrySimilar uptake but different trafficking and escape routes of reovirus virions and infectious subvirion particles imaged in polarized Madin-Darby canine kidney cells.Independent regulation of reovirus membrane penetration and apoptosis by the mu1 phi domainCleavage susceptibility of reovirus attachment protein sigma1 during proteolytic disassembly of virions is determined by a sequence polymorphism in the sigma1 neck.Reovirus growth in cell culture does not require the full complement of viral proteins: identification of a sigma1s-null mutant.Trypsin-induced structural transformation in aquareovirusMutant cells selected during persistent reovirus infection do not express mature cathepsin L and do not support reovirus disassembly.Adaptation of reovirus to growth in the presence of protease inhibitor E64 segregates with a mutation in the carboxy terminus of viral outer-capsid protein sigma3.A monoclonal antibody specific for reovirus outer-capsid protein sigma3 inhibits sigma1-mediated hemagglutination by steric hindrance.Identification of carbohydrate-binding domains in the attachment proteins of type 1 and type 3 reovirusesSubnanometer-resolution structures of the grass carp reovirus core and virion.Loss of sialic acid binding domain redirects protein σ1 to enhance M cell-directed vaccinationReovirus variants selected for resistance to ammonium chloride have mutations in viral outer-capsid protein sigma3.Virion disassembly is required for apoptosis induced by reovirus.A single mutation in the carboxy terminus of reovirus outer-capsid protein sigma 3 confers enhanced kinetics of sigma 3 proteolysis, resistance to inhibitors of viral disassembly, and alterations in sigma 3 structure.The viral sigma1 protein and glycoconjugates containing alpha2-3-linked sialic acid are involved in type 1 reovirus adherence to M cell apical surfaces.Antibodies against outer-capsid proteins of grass carp reovirus expressed in E. coli are capable of neutralizing viral infectivity.Homotrimeric, beta-stranded viral adhesins and tail proteinsReovirus receptors and pathogenesis.Differences in the capacity of reovirus strains to induce apoptosis are determined by the viral attachment protein sigma 1Role of the mu 1 protein in reovirus stability and capacity to cause chromium release from host cells.Persistent reovirus infections of L cells select mutations in viral attachment protein sigma1 that alter oligomer stabilityEfficiency of viral entry determines the capacity of murine erythroleukemia cells to support persistent infections by mammalian reoviruses.Reovirus variants selected during persistent infections of L cells contain mutations in the viral S1 and S4 genes and are altered in viral disassemblyMutations in type 3 reovirus that determine binding to sialic acid are contained in the fibrous tail domain of viral attachment protein sigma1.Thermostabilizing mutations in reovirus outer-capsid protein mu1 selected by heat inactivation of infectious subvirion particles.Reverse Genetics for Fusogenic Bat-Borne Orthoreovirus Associated with Acute Respiratory Tract Infections in Humans: Role of Outer Capsid Protein σC in Viral Replication and Pathogenesis.Mechanisms of reovirus bloodstream dissemination.From touchdown to transcription: the reovirus cell entry pathwaySecretory immunoglobulin A antibodies against the sigma1 outer capsid protein of reovirus type 1 Lang prevent infection of mouse Peyer's patches.Genetic determinants of reovirus pathogenesis in a murine model of respiratory infectionJunctional adhesion molecule a serves as a receptor for prototype and field-isolate strains of mammalian reovirus.Conformational changes required for reovirus cell entry are sensitive to pH.Reduction of virion-associated σ1 fibers on oncolytic reovirus variants promotes adaptation toward tumorigenic cells.The reovirus sigma1s protein is a determinant of hematogenous but not neural virus dissemination in mice.
P2860
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P2860
Infectious subvirion particles of reovirus type 3 Dearing exhibit a loss in infectivity and contain a cleaved sigma 1 protein
description
1995 nî lūn-bûn
@nan
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
1995年论文
@zh
1995年论文
@zh-cn
name
Infectious subvirion particles ...... tain a cleaved sigma 1 protein
@ast
Infectious subvirion particles ...... tain a cleaved sigma 1 protein
@en
type
label
Infectious subvirion particles ...... tain a cleaved sigma 1 protein
@ast
Infectious subvirion particles ...... tain a cleaved sigma 1 protein
@en
prefLabel
Infectious subvirion particles ...... tain a cleaved sigma 1 protein
@ast
Infectious subvirion particles ...... tain a cleaved sigma 1 protein
@en
P2093
P2860
P1433
P1476
Infectious subvirion particles ...... tain a cleaved sigma 1 protein
@en
P2093
J D Chappell
M L Nibert
T S Dermody
P2860
P304
P407
P577
1995-08-01T00:00:00Z