Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis. - Wikidata - awgldk - TriplyDB

Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis.

Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis.

http://www.wikidata.org/entity/Q35885582

about

Cloning and characterization of a novel Kruppel-associated box family transcriptional repressor that interacts with the retinoblastoma gene product, RB A novel transcriptional repression domain mediates p21(WAF1/CIP1) induction of p300 transactivation E2F transcriptional activation requires TRRAP and GCN5 cofactors E2F-7: a distinctive E2F family member with an unusual organization of DNA-binding domains PARP-1 binds E2F-1 independently of its DNA binding and catalytic domains, and acts as a novel coactivator of E2F-1-mediated transcription during re-entry of quiescent cells into S phase p38 phosphorylates Rb on Ser567 by a novel, cell cycle-independent mechanism that triggers Rb-Hdm2 interaction and apoptosis A novel p53-inducible apoptogenic gene, PRG3, encodes a homologue of the apoptosis-inducing factor (AIF)DNA-damage response control of E2F7 and E2F8 Use of chromatin immunoprecipitation to clone novel E2F target promoters Identification of a novel E2F3 product suggests a mechanism for determining specificity of repression by Rb proteins Rb and prohibitin target distinct regions of E2F1 for repression and respond to different upstream signals CDC25A phosphatase is a target of E2F and is required for efficient E2F-induced S phase PERP, an apoptosis-associated target of p53, is a novel member of the PMP-22/gas3 family The subcellular localization of E2F-4 is cell-cycle dependent Specific regulation of E2F family members by cyclin-dependent kinases Expression of the HsOrc1 gene, a human ORC1 homolog, is regulated by cell proliferation via the E2F transcription factor E2F-4 switches from p130 to p107 and pRB in response to cell cycle reentry Isolating human transcription factor targets by coupling chromatin immunoprecipitation and CpG island microarray analysis Identification of E-box factor TFE3 as a functional partner for the E2F3 transcription factor Cdc6 is regulated by E2F and is essential for DNA replication in mammalian cells NPAT expression is regulated by E2F and is essential for cell cycle progression Evaluating biomarkers to model cancer risk post cosmic ray exposure Redox regulation of FoxO transcription factors Network calisthenics: control of E2F dynamics in cell cycle entry Drugging the addict: non-oncogene addiction as a target for cancer therapy Cell growth-regulated expression of mammalian MCM5 and MCM6 genes mediated by the transcription factor E2F A 63-base pair DNA segment containing an Sp1 site but not a canonical E2F site can confer growth-dependent and E2F-mediated transcriptional stimulation of the human ASK gene encoding the regulatory subunit for human Cdc7-related kinase Synergistic role of E1A-binding proteins and tissue-specific transcription factors in differentiation Selective induction of E2F1 in response to DNA damage, mediated by ATM-dependent phosphorylation Cyclin A-CDK phosphorylates Sp1 and enhances Sp1-mediated transcription.14-3-3 proteins integrate E2F activity with the DNA damage response.Cooperation between the Cdk inhibitors p27(KIP1) and p57(KIP2) in the control of tissue growth and development TIP49, but not TRRAP, modulates c-Myc and E2F1 dependent apoptosis A specific, nonproliferative role for E2F-5 in choroid plexus function revealed by gene targeting Altered control of cellular proliferation in the absence of mammalian brahma (SNF2alpha).A role for E2F6 in distinguishing G1/S- and G2/M-specific transcription Activation of cyclin-dependent kinases by Myc mediates induction of cyclin A, but not apoptosis Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization AP-1 in cell proliferation and survival Inhibition of mammalian cell proliferation by genetically selected peptide aptamers that functionally antagonize E2F activity.

P2860

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P2860

Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis.

http://www.wikidata.org/entity/Q35885582

description

1994 nî lūn-bûn

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1994年の論文

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1994年学术文章

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1994年学术文章

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1994年学术文章

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1994年学术文章

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1994年学术文章

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1994年學術文章

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1994年學術文章

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1994年學術文章

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name

Deregulated transcription fact ...... ry and p53-mediated apoptosis.

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Deregulated transcription fact ...... ry and p53-mediated apoptosis.

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type

label

Deregulated transcription fact ...... ry and p53-mediated apoptosis.

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Deregulated transcription fact ...... ry and p53-mediated apoptosis.

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prefLabel

Deregulated transcription fact ...... ry and p53-mediated apoptosis.

@ast

Deregulated transcription fact ...... ry and p53-mediated apoptosis.

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PNAS.91.23.10918

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Proceedings of the National Academy of Sciences of the United States of America

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Deregulated transcription fact ...... ry and p53-mediated apoptosis.

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P2093

Adams PD

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Kaelin WG Jr

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Livingston DM

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Qin XQ

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P2860

Human wee1 maintains mitotic timing by protecting the nucleus from cytoplasmically activated Cdc2 kinase

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation

Oncogenic forms of p53 inhibit p53-regulated gene expression

Inhibition of cell proliferation by p107, a relative of the retinoblastoma protein

Amplification of a gene encoding a p53-associated protein in human sarcomas

p53 mutations in human cancers

The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

Induction of apoptosis in fibroblasts by c-myc protein

E2F: a link between the Rb tumor suppressor protein and viral oncoproteins

Effects of an Rb mutation in the mouse

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10918-10922

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10.1073/PNAS.91.23.10918

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7971984

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apoptotic process

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45137

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