Characterization of EHop-016, novel small molecule inhibitor of Rac GTPase - Wikidata - awgldk - TriplyDB

Characterization of EHop-016, novel small molecule inhibitor of Rac GTPase

Characterization of EHop-016, novel small molecule inhibitor of Rac GTPase

http://www.wikidata.org/entity/Q35921528

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Structural Mechanisms and Drug Discovery Prospects of Rho GTPases Modulation of actin dynamics by Rac1 to target cognitive function Approaches of targeting Rho GTPases in cancer drug discovery Inhibition of STAT5: a therapeutic option in BCR-ABL1-driven leukemia The roles of PIKE in tumorigenesis Novel Activities of Select NSAID R-Enantiomers against Rac1 and Cdc42 GTPases The Role of Rac1 in the Growth Cone Dynamics and Force Generation of DRG Neurons MST3 promotes proliferation and tumorigenicity through the VAV2/Rac1 signal axis in breast cancer.Preclinical development of novel Rac1-GEF signaling inhibitors using a rational design approach in highly aggressive breast cancer cell lines.Therapeutic sensitivity to Rac GTPase inhibition requires consequential suppression of mTORC1, AKT, and MEK signaling in breast cancer A sphingosine-1-phosphate receptor type 1 agonist, ASP4058, suppresses intracranial aneurysm through promoting endothelial integrity and blocking macrophage transmigration The Rac Inhibitor EHop-016 Inhibits Mammary Tumor Growth and Metastasis in a Nude Mouse Model.Targeting Rho-GTPases in immune cell migration and inflammation.Equol, an isoflavone metabolite, regulates cancer cell viability and protein synthesis initiation via c-Myc and eIF4G.Vav2 protein overexpression marks and may predict the aggressive subtype of ductal carcinoma in situ VAV2, a guanine nucleotide exchange factor for Rac1, regulates glucose-stimulated insulin secretion in pancreatic beta cells.A Novel Pharmacologic Activity of Ketorolac for Therapeutic Benefit in Ovarian Cancer Patients.P-Rex1 Promotes Resistance to VEGF/VEGFR-Targeted Therapy in Prostate Cancer.TCR-driven transendothelial migration of human effector memory CD4 T cells involves Vav, Rac, and myosin IIA Pak and Rac GTPases promote oncogenic KIT-induced neoplasms.Characterization of a P-Rex1 gene signature in breast cancer cells Teleocidin A2 inhibits human proteinase-activated receptor 2 signaling in tumor cells.R-spondin1 Controls Muscle Cell Fusion through Dual Regulation of Antagonistic Wnt Signaling Pathways.Role of Rac1-mineralocorticoid-receptor signalling in renal and cardiac disease.RAC1: an emerging therapeutic option for targeting cancer angiogenesis and metastasis.Implications of Rho GTPase Signaling in Glioma Cell Invasion and Tumor Progression.Growth factor transduction pathways: paradigm of anti-neoplastic targeted therapy.Three-dimensional patterning of multiple cell populations through orthogonal genetic control of cell motility BNIP3 supports melanoma cell migration and vasculogenic mimicry by orchestrating the actin cytoskeleton.Direct Modulation of Small GTPase Activity and Function.Involvement of Tiam1, RhoG and ELMO2/ILK in Rac1-mediated phagocytosis in human trabecular meshwork cells.Tyrosine 397 phosphorylation is critical for FAK-promoted Rac1 activation and invasive properties in oral squamous cell carcinoma cells.Rac1 in human diseases: The therapeutic potential of targeting Rac1 signaling regulatory mechanisms.The role of small GTPases of the Rho/Rac family in TGF-β-induced EMT and cell motility in cancer.Phosphorylated cortactin recruits Vav2 guanine nucleotide exchange factor to activate Rac3 and promote invadopodial function in invasive breast cancer cells.Tiam1/Vav2-Rac1 axis: A tug-of-war between islet function and dysfunction.PI3K signaling in cancer: beyond AKT.Migracins A and B, new inhibitors of cancer cell migration, produced by Streptomyces sp.Rho GTPases as therapeutic targets in cancer (Review).Integrin-α10 Dependency Identifies RAC and RICTOR as Therapeutic Targets in High-Grade Myxofibrosarcoma.

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P2860

Characterization of EHop-016, novel small molecule inhibitor of Rac GTPase

http://www.wikidata.org/entity/Q35921528

description

2012 nî lūn-bûn

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2012年の論文

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2012年論文

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2012年论文

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Characterization of EHop-016, novel small molecule inhibitor of Rac GTPase

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Characterization of EHop-016, novel small molecule inhibitor of Rac GTPase

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Characterization of EHop-016, novel small molecule inhibitor of Rac GTPase

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Characterization of EHop-016, novel small molecule inhibitor of Rac GTPase

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Characterization of EHop-016, novel small molecule inhibitor of Rac GTPase

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Characterization of EHop-016, novel small molecule inhibitor of Rac GTPase

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JBC.M111.334524

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Journal of Biological Chemistry

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Characterization of EHop-016, novel small molecule inhibitor of Rac GTPase

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P2093

Alina De la Mota-Peynado

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Brenda L Montalvo-Ortiz

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Cornelis P Vlaar

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Eliud Hernández

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Linette Castillo-Pichardo

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Luis A Cubano

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Tessa Humphries-Bickley

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P2860

Rac1 and Rac3 isoform activation is involved in the invasive and metastatic phenotype of human breast cancer cells

Rac and Rho GTPases in cancer cell motility control

Crucial structural role for the PH and C1 domains of the Vav1 exchange factor

Novel association of Vav2 and Nek3 modulates signaling through the human prolactin receptor

Vav2 activates Rac1, Cdc42, and RhoA downstream from growth factor receptors but not beta1 integrins

Endogenous, hyperactive Rac3 controls proliferation of breast cancer cells by a p21-activated kinase-dependent pathway

Rho GTPases in hematopoiesis and hemopathies

PTP-PEST couples membrane protrusion and tail retraction via VAV2 and p190RhoGAP.

Crystal structure of Rac1 in complex with the guanine nucleotide exchange region of Tiam1

Structural Basis of Guanine Nucleotide Exchange Mediated by the T-Cell Essential Vav1

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16

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287

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Suranganie Dharmawardhane

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2012-03-01T00:00:00Z

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22383527

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3339933

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