CD73-generated extracellular adenosine in chronic lymphocytic leukemia creates local conditions counteracting drug-induced cell death - Wikidata - awgldk - TriplyDB

CD73-generated extracellular adenosine in chronic lymphocytic leukemia creates local conditions counteracting drug-induced cell death

CD73-generated extracellular adenosine in chronic lymphocytic leukemia creates local conditions counteracting drug-induced cell death

http://www.wikidata.org/entity/Q35930211

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Purinergic signalling and cancer A Metabolic Immune Checkpoint: Adenosine in Tumor Microenvironment CD73-generated adenosine: orchestrating the tumor-stroma interplay to promote cancer growth Anti-CD38 antibody therapy: windows of opportunity yielded by the functional characteristics of the target molecule HLA-G is a component of the chronic lymphocytic leukemia escape repertoire to generate immune suppression: impact of the HLA-G 14 base pair (rs66554220) polymorphism.Immune checkpoint blockade for hematologic malignancies: a review The roles of CD73 in cancer Resident cardiac immune cells and expression of the ectonucleotidase enzymes CD39 and CD73 after ischemic injury.Big opportunities for small molecules in immuno-oncology.Biological functions of ecto-enzymes in regulating extracellular adenosine levels in neoplastic and inflammatory disease states.Ecto-5'-nucleotidase expression is associated with the progression of renal cell carcinoma.Critical Role for the Adenosine Pathway in Controlling Simian Immunodeficiency Virus-Related Immune Activation and Inflammation in Gut Mucosal Tissues The coding genome of splenic marginal zone lymphoma: activation of NOTCH2 and other pathways regulating marginal zone development.Idelalisib and caffeine reduce suppression of T cell responses mediated by activated chronic lymphocytic leukemia cells.Ectonucleotidases in solid organ and allogeneic hematopoietic cell transplantation Anti-CD73 in cancer immunotherapy: awakening new opportunities.Antitumor effect of combined NAMPT and CD73 inhibition in an ovarian cancer model.CD39 and CD73 in immunity and inflammation.The monocytic population in chronic lymphocytic leukemia shows altered composition and deregulation of genes involved in phagocytosis and inflammation.CD73 promotes anthracycline resistance and poor prognosis in triple negative breast cancer Synergy between the ectoenzymes CD39 and CD73 contributes to adenosinergic immunosuppression in human malignant gliomas.CD73 is associated with poor prognosis in HNSCC.Humoral immune responses toward tumor-derived antigens in previously untreated patients with chronic lymphocytic leukemia.Production of adenosine by ectonucleotidases: a key factor in tumor immunoescape.CD73 and adenosine generation in the creation of regulatory microenvironments.Targeting CD73 and downstream adenosine receptor signaling in triple-negative breast cancer.CD73-adenosine: a next-generation target in immuno-oncology.A preliminary study of the role of extracellular -5'- nucleotidase in breast cancer stem cells and epithelial-mesenchymal transition.Adenosine-mediated immunosuppression in patients with squamous cell carcinoma of the head and neck.Pathological overproduction: the bad side of adenosine.The ectonucleotidases CD39 and CD73: Novel checkpoint inhibitor targets.Mechanisms of Resistance to Targeted Therapies in Chronic Lymphocytic Leukemia.CCR6 Deficiency Impairs IgA Production and Dysregulates Antimicrobial Peptide Production, Altering the Intestinal Flora.A CD38/CD203a/CD73 ectoenzymatic pathway independent of CD39 drives a novel adenosinergic loop in human T lymphocytes.Multifaceted Effects of Extracellular Adenosine Triphosphate and Adenosine in the Tumor-Host Interaction and Therapeutic Perspectives.Targeting immunosuppressive adenosine in cancer.Eviction from the sanctuary: Development of targeted therapy against cell adhesion molecules in acute lymphoblastic leukemia.CD73-A2a adenosine receptor axis promotes innate B cell antibody responses to pneumococcal polysaccharide vaccination.Drug-induced ciliogenesis in pancreatic cancer cells is facilitated by the secreted ATP-purinergic receptor signaling pathway.The influence of chemotherapy on adenosine-producing B cells in patients with head and neck squamous cell carcinoma.

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P2860

CD73-generated extracellular adenosine in chronic lymphocytic leukemia creates local conditions counteracting drug-induced cell death

http://www.wikidata.org/entity/Q35930211

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Alberto L Horenstein

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Davide Rossi

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Giorgio Inghirami

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Giovanni D'Arena

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Luca Laurenti

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Sara Serra

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Silvia Deaglio

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Simon C Robson

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P2860

Adenosine receptors: therapeutic aspects for inflammatory and immune diseases.

Ecto-enzyme and signaling functions of lymphocyte CD73

Increased level of extracellular ATP at tumor sites: in vivo imaging with plasma membrane luciferase

A(2A) receptor dependent and A(2A) receptor independent effects of extracellular adenosine on murine thymocytes in conditions of adenosine deaminase deficiency

Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression.

Much ado about adenosine: adenosine synthesis and function in regulatory T cell biology.

The endothelial cell ecto-ADPase responsible for inhibition of platelet function is CD39.

Cellular origin(s) of chronic lymphocytic leukemia: cautionary notes and additional considerations and possibilities.

CD73 on tumor cells impairs antitumor T-cell responses: a novel mechanism of tumor-induced immune suppression

Anti-CD73 antibody therapy inhibits breast tumor growth and metastasis.

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6141-6152

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23

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118

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Gianluca Gaidano

Claudio Tripodo

Giorgio Inghirami

Tiziana Vaisitti

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2011-10-13T00:00:00Z

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51716163

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21998208

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