Allosteric gating mechanism underlies the flexible gating of KCNQ1 potassium channels.
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Cellular mechanisms of mutations in Kv7.1: auditory functions in Jervell and Lange-Nielsen syndrome vs. Romano-Ward syndromeThe KCNQ1 channel - remarkable flexibility in gating allows for functional versatilityIKs channels open slowly because KCNE1 accessory subunits slow the movement of S4 voltage sensors in KCNQ1 pore-forming subunitsMechanical gating of a mechanochemical reaction cascadeRegulation of KCNQ/Kv7 family voltage-gated K+ channels by lipids.KCNE1 divides the voltage sensor movement in KCNQ1/KCNE1 channels into two stepsFunctional heterogeneity of the four voltage sensors of a human L-type calcium channelDomain-domain interactions determine the gating, permeation, pharmacology, and subunit modulation of the IKs ion channelPolyunsaturated fatty acid analogs act antiarrhythmically on the cardiac IKs channelCoupling of voltage-sensors to the channel pore: a comparative viewKCNE3 acts by promoting voltage sensor activation in KCNQ1.Perspectives on: conformational coupling in ion channels: thermodynamics of electromechanical coupling in voltage-gated ion channels.Single-channel basis for the slow activation of the repolarizing cardiac potassium current, I(Ks)KCNE1 and KCNE3: The yin and yang of voltage-gated K(+) channel regulationKv7.1 ion channels require a lipid to couple voltage sensing to pore opening.Gating mechanisms underlying deactivation slowing by two KCNQ1 atrial fibrillation mutations.Being flexible: the voltage-controllable activation gate of kv channels.PIP2 regulation of KCNQ channels: biophysical and molecular mechanisms for lipid modulation of voltage-dependent gating.Modeling ion channels: past, present, and futurePurification and structural study of the voltage-sensor domain of the human KCNQ1 potassium ion channelVoltage-Dependent Gating: Novel Insights from KCNQ1 Channels.Fatty acid analogue N-arachidonoyl taurine restores function of IKs channels with diverse long QT mutations.Molecular Pathophysiology of Congenital Long QT Syndrome.Chansporter complexes in cell signaling.SUMOylation determines the voltage required to activate cardiac IKs channels.hERG S4-S5 linker acts as a voltage-dependent ligand that binds to the activation gate and locks it in a closed stateGrafting voltage and pharmacological sensitivity in potassium channelsKCNQ1 channels do not undergo concerted but sequential gating transitions in both the absence and the presence of KCNE1 proteinAn allosteric gating model recapitulates the biophysical properties of IK,L expressed in mouse vestibular type I hair cells.KCNE1 and KCNE3 modulate KCNQ1 channels by affecting different gating transitions.Inactivation gating of Kv7.1 channels does not involve concerted cooperative subunit interactions.Steric hindrance between S4 and S5 of the KCNQ1/KCNE1 channel hampers pore opening.
P2860
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P2860
Allosteric gating mechanism underlies the flexible gating of KCNQ1 potassium channels.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
Allosteric gating mechanism underlies the flexible gating of KCNQ1 potassium channels.
@ast
Allosteric gating mechanism underlies the flexible gating of KCNQ1 potassium channels.
@en
type
label
Allosteric gating mechanism underlies the flexible gating of KCNQ1 potassium channels.
@ast
Allosteric gating mechanism underlies the flexible gating of KCNQ1 potassium channels.
@en
prefLabel
Allosteric gating mechanism underlies the flexible gating of KCNQ1 potassium channels.
@ast
Allosteric gating mechanism underlies the flexible gating of KCNQ1 potassium channels.
@en
P2093
P2860
P356
P1476
Allosteric gating mechanism underlies the flexible gating of KCNQ1 potassium channels.
@en
P2093
H Peter Larsson
Jeremiah D Osteen
Kevin J Sampson
Rene Barro-Soria
Robert S Kass
Seth Robey
P2860
P304
P356
10.1073/PNAS.1201582109
P407
P577
2012-04-16T00:00:00Z