Modifying the sequence of an immunoglobulin V-gene alters the resulting pattern of hypermutation.
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AID-GFP chimeric protein increases hypermutation of Ig genes with no evidence of nuclear localization.Somatic hypermutation introduces insertions and deletions into immunoglobulin V genesFrequent occurrence of deletions and duplications during somatic hypermutation: implications for oncogene translocations and heavy chain diseaseImproving antibody affinity by mimicking somatic hypermutation in vitro.Gene-Specific Substitution Profiles Describe the Types and Frequencies of Amino Acid Changes during Antibody Somatic Hypermutation.Chance favors the prepared genome.Cells strongly expressing Ig(kappa) transgenes show clonal recruitment of hypermutation: a role for both MAR and the enhancers.Mechanisms of chromosomal translocations in B cell lymphomas.AID to overcome the limitations of genomic information by introducing somatic DNA alterations.The Ig mutator is dependent on the presence, position, and orientation of the large intron enhancer.Both DNA strands of antibody genes are hypermutation targets.Antibodyomics: bioinformatics technologies for understanding B-cell immunity to HIV-1.A hypermutable insert in an immunoglobulin transgene contains hotspots of somatic mutation and sequences predicting highly stable structures in the RNA transcriptSequence dependent hypermutation of the immunoglobulin heavy chain in cultured B cells.Functional Versatility of AGY Serine Codons in Immunoglobulin Variable Region Genes.The antibody mining toolbox: an open source tool for the rapid analysis of antibody repertoires.The intrinsic hypermutability of antibody heavy and light chain genes decays exponentially.Sequence intrinsic somatic mutation mechanisms contribute to affinity maturation of VRC01-class HIV-1 broadly neutralizing antibodies.Clonal instability of V region hypermutation in the Ramos Burkitt's lymphoma cell line.Somatic hypermutation of antibody genes: a hot spot warms up.Inherent properties of somatic hypermutation as revealed by human non-productive VH6 immunoglobulin rearrangements.
P2860
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P2860
Modifying the sequence of an immunoglobulin V-gene alters the resulting pattern of hypermutation.
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年学术文章
@wuu
1996年学术文章
@zh-cn
1996年学术文章
@zh-hans
1996年学术文章
@zh-my
1996年学术文章
@zh-sg
1996年學術文章
@yue
1996年學術文章
@zh
1996年學術文章
@zh-hant
name
Modifying the sequence of an i ...... ting pattern of hypermutation.
@ast
Modifying the sequence of an i ...... ting pattern of hypermutation.
@en
type
label
Modifying the sequence of an i ...... ting pattern of hypermutation.
@ast
Modifying the sequence of an i ...... ting pattern of hypermutation.
@en
prefLabel
Modifying the sequence of an i ...... ting pattern of hypermutation.
@ast
Modifying the sequence of an i ...... ting pattern of hypermutation.
@en
P2860
P356
P1476
Modifying the sequence of an i ...... ting pattern of hypermutation.
@en
P2093
Goyenechea B
Milstein C
P2860
P304
13979-13984
P356
10.1073/PNAS.93.24.13979
P407
P577
1996-11-01T00:00:00Z