Patterns of somatic mutations in immunoglobulin variable genes
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Somatic hypermutation of the AID transgene in B and non-B cellsSomatic hypermutation introduces insertions and deletions into immunoglobulin V genesAntibody WN1 222-5 mimics Toll-like receptor 4 binding in the recognition of LPSStructural, molecular and cellular functions of MSH2 and MSH6 during DNA mismatch repair, damage signaling and other noncanonical activitiesIncreased hypermutation at G and C nucleotides in immunoglobulin variable genes from mice deficient in the MSH2 mismatch repair proteinAltered spectra of hypermutation in antibodies from mice deficient for the DNA mismatch repair protein PMS2A Model of Somatic Hypermutation Targeting in Mice Based on High-Throughput Ig Sequencing Data.Sequences of 12 monoclonal anti-dinitrophenyl spin-label antibodies for NMR studies.Genetic basis of the antibody repertoire in Xenopus: analysis of the Vh diversity.Altered spectra of hypermutation in DNA repair-deficient mice.A new class of errant DNA polymerases provides candidates for somatic hypermutation.A target selection of somatic hypermutations is regulated similarly between T and B cells upon activation-induced cytidine deaminase expressionEvolution and the molecular basis of somatic hypermutation of antigen receptor genes.Analysis of somatic mutation in five B cell subsets of human tonsil.Genome-wide detection of genes targeted by non-Ig somatic hypermutation in lymphomaSpt5 accumulation at variable genes distinguishes somatic hypermutation in germinal center B cells from ex vivo-activated cells.Class-switch recombination: after the dawn of AID.Overlapping hotspots in CDRs are critical sites for V region diversificationModifying the sequence of an immunoglobulin V-gene alters the resulting pattern of hypermutation.Somatic mutation of immunoglobulin lambda chains: a segment of the major intron hypermutates as much as the complementarity-determining regions.DNA sequences of genes encoding Acinetobacter calcoaceticus protocatechuate 3,4-dioxygenase: evidence indicating shuffling of genes and of DNA sequences within genes during their evolutionary divergence.Passenger transgenes reveal intrinsic specificity of the antibody hypermutation mechanism: clustering, polarity, and specific hot spots.Does DNA repair occur during somatic hypermutation?Different epitope structures select distinct mutant forms of an antibody variable region for expression during the immune response.Analysis of a T cell receptor gene as a target of the somatic hypermutation mechanism.In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. II. A common clonal origin for periarteriolar lymphoid sheath-associated foci and germinal centers.BCL-6 mutations in normal germinal center B cells: evidence of somatic hypermutation acting outside Ig loci.Analysis of somatic mutations in kappa transgenes.Boundaries of somatic mutation in rearranged immunoglobulin genes: 5' boundary is near the promoter, and 3' boundary is approximately 1 kb from V(D)J gene.Mutational hot spots in Ig V region genes of human follicular lymphomasEarly onset of somatic mutation in immunoglobulin VH genes during the primary immune responseEvolution of antibody structure during the immune response. The differentiative potential of a single B lymphocyte.Hypermutation is observed only in antibody H chain V region transgenes that have recombined with endogenous immunoglobulin H DNA: implications for the location of cis-acting elements required for somatic mutationIn situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. III. The kinetics of V region mutation and selection in germinal center B cellsRandom mutagenesis of two complementarity determining region amino acids yields an unexpectedly high frequency of antibodies with increased affinity for both cognate antigen and autoantigen.A hypermutable insert in an immunoglobulin transgene contains hotspots of somatic mutation and sequences predicting highly stable structures in the RNA transcriptSequence dependent hypermutation of the immunoglobulin heavy chain in cultured B cells.Long-lived antigen-induced IgM plasma cells demonstrate somatic mutations and contribute to long-term protection.Genomic targeting with a positive-selection lox integration vector allows highly reproducible gene expression in mammalian cells.DNA polymerase mu (Pol mu), homologous to TdT, could act as a DNA mutator in eukaryotic cells.
P2860
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P2860
Patterns of somatic mutations in immunoglobulin variable genes
description
1987 nî lūn-bûn
@nan
1987 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
1987 թվականի հունվարին հրատարակված գիտական հոդված
@hy
1987年の論文
@ja
1987年論文
@yue
1987年論文
@zh-hant
1987年論文
@zh-hk
1987年論文
@zh-mo
1987年論文
@zh-tw
1987年论文
@wuu
name
Patterns of somatic mutations in immunoglobulin variable genes
@ast
Patterns of somatic mutations in immunoglobulin variable genes
@en
type
label
Patterns of somatic mutations in immunoglobulin variable genes
@ast
Patterns of somatic mutations in immunoglobulin variable genes
@en
prefLabel
Patterns of somatic mutations in immunoglobulin variable genes
@ast
Patterns of somatic mutations in immunoglobulin variable genes
@en
P2093
P2860
P1433
P1476
Patterns of somatic mutations in immunoglobulin variable genes
@en
P2093
B W Glickman
G B Golding
P J Gearhart
P2860
P304
P407
P577
1987-01-01T00:00:00Z