Both DNA strands of antibody genes are hypermutation targets. - Wikidata - awgldk - TriplyDB

Both DNA strands of antibody genes are hypermutation targets.

Both DNA strands of antibody genes are hypermutation targets.

http://www.wikidata.org/entity/Q36220380

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The RNA exosome targets the AID cytidine deaminase to both strands of transcribed duplex DNA substrates AID-GFP chimeric protein increases hypermutation of Ig genes with no evidence of nuclear localization.Memory in the B-cell compartment: antibody affinity maturation Expression of human AID in yeast induces mutations in context similar to the context of somatic hypermutation at G-C pairs in immunoglobulin genes Related Mechanisms of Antibody Somatic Hypermutation and Class Switch Recombination RNA Exosome Regulates AID DNA Mutator Activity in the B Cell Genome First AID (activation-induced cytidine deaminase) is needed to produce high affinity isotype-switched antibodies Somatic hypermutation in MutS homologue (MSH)3-, MSH6-, and MSH3/MSH6-deficient mice reveals a role for the MSH2-MSH6 heterodimer in modulating the base substitution pattern Diffuse large B-cell lymphoma: can genomics improve treatment options for a curable cancer?A new class of errant DNA polymerases provides candidates for somatic hypermutation.Variable deletion and duplication at recombination junction ends: implication for staggered double-strand cleavage in class-switch recombination Correlation of somatic hypermutation specificity and A-T base pair substitution errors by DNA polymerase eta during copying of a mouse immunoglobulin kappa light chain transgene.Uracil excision by endogenous SMUG1 glycosylase promotes efficient Ig class switching and impacts on A:T substitutions during somatic mutation In vivo and in vitro studies of immunoglobulin gene somatic hypermutation.Antibody diversification and selection in the mature B-cell compartment.Quantifying selection in high-throughput Immunoglobulin sequencing data sets Genesis of the strand-biased signature in somatic hypermutation of rearranged immunoglobulin variable genes.Spt5 accumulation at variable genes distinguishes somatic hypermutation in germinal center B cells from ex vivo-activated cells.Emerging links between hypermutation of antibody genes and DNA polymerases.DNA breaks in hypermutating immunoglobulin genes: evidence for a break-and-repair pathway of somatic hypermutation Activation-induced cytidine deaminase action is strongly stimulated by mutations of the THO complex Mechanism and regulation of class switch recombination What role for AID: mutator, or assembler of the immunoglobulin mutasome?Recombinase-mediated cassette exchange as a novel method to study somatic hypermutation in Ramos cells Somatic hypermutation patterns in germinal center B cell malignancies.On the molecular mechanism of somatic hypermutation of rearranged immunoglobulin genes.DNA deamination in immunity.Cerebrospinal fluid B cells from multiple sclerosis patients are subject to normal germinal center selection.Detection of chromatin-associated single-stranded DNA in regions targeted for somatic hypermutation.Error-prone candidates vie for somatic mutation DNA repair in antibody somatic hypermutation.Does antisense make sense of AID targeting?Antisense transcripts from immunoglobulin heavy-chain locus V(D)J and switch regions Expression of error-prone polymerases in BL2 cells activated for Ig somatic hypermutation.Interplay between Target Sequences and Repair Pathways Determines Distinct Outcomes of AID-Initiated Lesions Characterization of Ig gene somatic hypermutation in the absence of activation-induced cytidine deaminase.Identification of murine B cell lines that undergo somatic hypermutation focused to A:T and G:C residues.Activation-induced cytidine deaminase (AID) can target both DNA strands when the DNA is supercoiled.BRILIA: Integrated Tool for High-Throughput Annotation and Lineage Tree Assembly of B-Cell Repertoires.DNA polymerases β and λ do not directly affect Ig variable region somatic hypermutation although their absence reduces the frequency of mutations.

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P2860

Both DNA strands of antibody genes are hypermutation targets.

http://www.wikidata.org/entity/Q36220380

description

1998 nî lūn-bûn

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1998年の論文

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1998年論文

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1998年論文

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1998年論文

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1998年論文

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1998年論文

@zh-tw

1998年论文

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1998年论文

@zh

1998年论文

@zh-cn

name

Both DNA strands of antibody genes are hypermutation targets.

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Both DNA strands of antibody genes are hypermutation targets.

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type

label

Both DNA strands of antibody genes are hypermutation targets.

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Both DNA strands of antibody genes are hypermutation targets.

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prefLabel

Both DNA strands of antibody genes are hypermutation targets.

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Both DNA strands of antibody genes are hypermutation targets.

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P1476

Both DNA strands of antibody genes are hypermutation targets.

@en

P2093

Milstein C

http://www.w3.org/2001/XMLSchema#string

Neuberger MS

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Staden R

http://www.w3.org/2001/XMLSchema#string

P2860

Cells strongly expressing Ig(kappa) transgenes show clonal recruitment of hypermutation: a role for both MAR and the enhancers.

Modifying the sequence of an immunoglobulin V-gene alters the resulting pattern of hypermutation.

Somatic mutation of immunoglobulin lambda chains: a segment of the major intron hypermutates as much as the complementarity-determining regions.

Passenger transgenes reveal intrinsic specificity of the antibody hypermutation mechanism: clustering, polarity, and specific hot spots.

Boundaries of somatic mutation in rearranged immunoglobulin genes: 5' boundary is near the promoter, and 3' boundary is approximately 1 kb from V(D)J gene.

The transcriptional promoter regulates hypermutation of the antibody heavy chain locus.

Analysis of somatic hypermutation in mouse Peyer's patches using immunoglobulin kappa light-chain transgenes

The efficiency of antibody affinity maturation: can the rate of B-cell division be limiting?

Somatic hypermutation.

Biochemical basis of DNA replication fidelity.

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8791-8794

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scholarly article

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10.1073/PNAS.95.15.8791

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15

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