Cellular responses to the metal-binding properties of metformin. - Wikidata - awgldk - TriplyDB

Cellular responses to the metal-binding properties of metformin.

Cellular responses to the metal-binding properties of metformin.

http://www.wikidata.org/entity/Q35976604

about

Repurposing metformin: an old drug with new tricks in its binding pockets Molecular mechanism of action of metformin: old or new insights?Something old, something new and something very old: drugs for treating type 2 diabetes New promises for metformin: advances in the understanding of its mechanisms of action Investigation of salicylate hepatic responses in comparison with chemical analogues of the drug To Use or Not to Use Metformin in Cerebral Ischemia: A Review of the Application of Metformin in Stroke Rodents AMP-activated protein kinase (AMPK)α2 plays a role in determining the cellular fate of glucose in insulin-resistant mouse skeletal muscle.The LKB1-salt-inducible kinase pathway functions as a key gluconeogenic suppressor in the liver.Disulfiram/copper-disulfiram Damages Multiple Protein Degradation and Turnover Pathways and Cytotoxicity is Enhanced by Metformin in Oesophageal Squamous Cell Carcinoma Cell Lines.Treatment with a copper-selective chelator causes substantive improvement in cardiac function of diabetic rats with left-ventricular impairment Potential applications for biguanides in oncology A marriage of two "Methusalem" drugs for the treatment of psoriasis?: Arguments for a pilot trial with metformin as add-on for methotrexate.Anti-Inflammatory Effects of Metformin Irrespective of Diabetes Status Regulation of metformin response by breast cancer associated gene 2.Metformin: A Hopeful Promise in Aging Research.Dissecting copper homeostasis in diabetes mellitus.The mechanisms of action of metformin.New Evidence for the Mechanism of Action of a Type-2 Diabetes Drug Using a Magnetic Bead-Based Automated Biosensing Platform.Metformin directly acts on mitochondria to alter cellular bioenergetics.Metformin selectively targets redox control of complex I energy transduction.The enhancement of oxidative DNA damage by anti-diabetic metformin, buformin, and phenformin, via nitrogen-centered radicals.Metformin alleviates nickel-induced autophagy and apoptosis via inhibition of hexokinase-2, activating lipocalin-2, in human bronchial epithelial cells.Iron reduction response and demographic differences between diabetics and non-diabetics with cardiovascular disease entered into a controlled clinical trial.Transcriptomic and proteomic analysis of potential therapeutic target genes in the liver of metformin‑treated Sprague‑Dawley rats with type 2 diabetes mellitus.Transcriptional remodeling in response to transfer upon carbon-limited or metformin-supplemented media in S. cerevisiae and its effect on chronological life span.Metformin exerts antitumor activity via induction of multiple death pathways in tumor cells and activation of a protective immune response.The copper binding properties of metformin – QCM-D, XPS and nanobead agglomeration

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Cellular responses to the metal-binding properties of metformin.

http://www.wikidata.org/entity/Q35976604

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2012 nî lūn-bûn

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2012年の論文

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2012年学术文章

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2012年学术文章

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2012年学术文章

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2012年学术文章

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2012年学术文章

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2012年學術文章

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2012年學術文章

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2012年學術文章

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name

Cellular responses to the metal-binding properties of metformin.

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Cellular responses to the metal-binding properties of metformin.

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Cellular responses to the metal-binding properties of metformin.

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Cellular responses to the metal-binding properties of metformin.

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Cellular responses to the metal-binding properties of metformin.

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Cellular responses to the metal-binding properties of metformin

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Gordon McDougall

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Hua Jiang

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Huan-Huan Wang

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Jean Harthill

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Katherine Macrae

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Kei Sakamoto

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Lin Xue

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Sandra Bacon

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P2860

Roles of the forkhead in rhabdomyosarcoma (FKHR) phosphorylation sites in regulating 14-3-3 binding, transactivation and nuclear targetting

Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B

Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain

Studies on the metabolism of troglitazone to reactive intermediates in vitro and in vivo. Evidence for novel biotransformation pathways involving quinone methide formation and thiazolidinedione ring scission.

Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state.

Cardiac copper deficiency activates a systemic signaling mechanism that communicates with the copper acquisition and storage organs.

A mechanism for the action of penicillamine in the treatment of Wilson's disease.

Biguanide metformin acts on tau phosphorylation via mTOR/protein phosphatase 2A (PP2A) signaling

Dimethylbiguanide inhibits cell respiration via an indirect effect targeted on the respiratory chain complex I.

The Anti-diabetic drugs rosiglitazone and metformin stimulate AMP-activated protein kinase through distinct signaling pathways.

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Alan R. Prescott

Kashyap A Patel

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