The Anti-diabetic drugs rosiglitazone and metformin stimulate AMP-activated protein kinase through distinct signaling pathways.
about
Modulation of de novo purine biosynthesis leads to activation of AMPK and results in improved glucose handling and insulin sensitivityComplexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascadeMetabolic actions of metformin in the heart can occur by AMPK-independent mechanismsMetformin and phenformin activate AMP-activated protein kinase in the heart by increasing cytosolic AMP concentrationMetformin counters the insulin-induced suppression of fatty acid oxidation and stimulation of triacylglycerol storage in rodent skeletal muscleRegulation of AMP-activated protein kinase by a pseudosubstrate sequence on the gamma subunitLKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activityFibroblast growth factor 21 regulates energy metabolism by activating the AMPK-SIRT1-PGC-1alpha pathwayCBS domains form energy-sensing modules whose binding of adenosine ligands is disrupted by disease mutationsMetformin activates AMP kinase through inhibition of AMP deaminaseThe tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stressPioglitazone acutely reduces insulin secretion and causes metabolic deceleration of the pancreatic beta-cell at submaximal glucose concentrationsIntrasteric control of AMPK via the gamma1 subunit AMP allosteric regulatory siteUpregulation of mitochondrial uncoupling protein-2 by the AMP-activated protein kinase in endothelial cells attenuates oxidative stress in diabetesThrombin activates AMP-activated protein kinase in endothelial cells via a pathway involving Ca2+/calmodulin-dependent protein kinase kinase betaAt the crossroads: AMP-activated kinase and the LKB1 tumor suppressor link cell proliferation to metabolic regulationThe Role of Common Pharmaceutical Agents on the Prevention and Treatment of Pancreatic CancerHypothalamic AMPK as a Regulator of Energy HomeostasisHydroxycinnamic acid derivatives: a potential class of natural compounds for the management of lipid metabolism and obesityAMPK activators: mechanisms of action and physiological activitiesDiabetes mellitus and renal failure: Prevention and managementAMPK as a potential anticancer target - friend or foe?AMP-activated protein kinase: a target for drugs both ancient and modernAMP-activated protein kinase: an energy sensor that regulates all aspects of cell functionPurification and characterization of the three Snf1-activating kinases of Saccharomyces cerevisiae.Adenosine monophosphate-activated protein kinase-based classification of diabetes pharmacotherapyInhibition of inducible nitric-oxide synthase by activators of AMP-activated protein kinase: a new mechanism of action of insulin-sensitizing drugsAMP-activated protein kinase mediates phenobarbital induction of CYP2B gene expression in hepatocytes and a newly derived human hepatoma cell lineMetformin induces a dietary restriction-like state and the oxidative stress response to extend C. elegans Healthspan via AMPK, LKB1, and SKN-1BMS309403 stimulates glucose uptake in myotubes through activation of AMP-activated protein kinaseActivation of AMPK by the putative dietary restriction mimetic metformin is insufficient to extend lifespan in DrosophilaTwo weeks of metformin treatment enhances mitochondrial respiration in skeletal muscle of AMPK kinase dead but not wild type miceShizukaol D isolated from Chloranthus japonicas inhibits AMPK-dependent lipid content in hepatic cells by inducing mitochondrial dysfunctionMetformin protects cardiomyocyte from doxorubicin induced cytotoxicity through an AMP-activated protein kinase dependent signaling pathway: an in vitro studyLipopolysaccharide-induced loss of cultured rat myenteric neurons - role of AMP-activated protein kinaseXanthene derivatives increase glucose utilization through activation of LKB1-dependent AMP-activated protein kinaseDibenzoylmethane exerts metabolic activity through regulation of AMP-activated protein kinase (AMPK)-mediated glucose uptake and adipogenesis pathwaysBasal Autophagy and Feedback Activation of Akt Are Associated with Resistance to Metformin-Induced Inhibition of Hepatic Tumor Cell GrowthMetformin Antagonizes Cancer Cell Proliferation by Suppressing Mitochondrial-Dependent Biosynthesis
P2860
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P2860
The Anti-diabetic drugs rosiglitazone and metformin stimulate AMP-activated protein kinase through distinct signaling pathways.
description
2002 nî lūn-bûn
@nan
2002 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
The Anti-diabetic drugs rosigl ...... h distinct signaling pathways.
@ast
The Anti-diabetic drugs rosigl ...... h distinct signaling pathways.
@en
The Anti-diabetic drugs rosigl ...... h distinct signaling pathways.
@nl
type
label
The Anti-diabetic drugs rosigl ...... h distinct signaling pathways.
@ast
The Anti-diabetic drugs rosigl ...... h distinct signaling pathways.
@en
The Anti-diabetic drugs rosigl ...... h distinct signaling pathways.
@nl
prefLabel
The Anti-diabetic drugs rosigl ...... h distinct signaling pathways.
@ast
The Anti-diabetic drugs rosigl ...... h distinct signaling pathways.
@en
The Anti-diabetic drugs rosigl ...... h distinct signaling pathways.
@nl
P356
P1476
The Anti-diabetic drugs rosigl ...... gh distinct signaling pathways
@en
P2093
Asha Parbu-Patel
Lee G D Fryer
P304
25226-25232
P356
10.1074/JBC.M202489200
P407
P577
2002-05-06T00:00:00Z