The human beta-globin gene contains multiple regulatory regions: identification of one promoter and two downstream enhancers.
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Initiation of DNA replication at the human beta-globin 3' enhancer.Beta-globin LCR and intron elements cooperate and direct spatial reorganization for gene therapyCis- and trans-acting elements involved in the regulation of the erythroid promoter of the human porphobilinogen deaminase geneA directly repeated sequence in the beta-globin promoter regulates transcription in murine erythroleukemia cellsEfficient, specific, developmentally appropriate cre-mediated recombination in anterior pituitary gonadotropes and thyrotropes.Evaluation of regulatory potential and conservation scores for detecting cis-regulatory modules in aligned mammalian genome sequences.Definition of the minimal requirements within the human beta-globin gene and the dominant control region for high level expression.The beta-globin dominant control region: hypersensitive site 2Detailed analysis of the site 3 region of the human beta-globin dominant control regionEvolution of hemoglobin and its genesSynthetic human beta-globin 5'HS2 constructs function as locus control regions only in multicopy transgene concatamers.The minimal requirements for activity in transgenic mice of hypersensitive site 3 of the beta globin locus control region.Identification of a transcriptional silencer in the 5'-flanking region of the human epsilon-globin gene.Specific ablation of human immunodeficiency virus Tat-expressing cells by conditionally toxic retrovirusesStudying the recruitment of Sp1 to the beta-globin promoter with an in vivo method: protein position identification with nuclease tail (PIN*POINT)Recombinant human hemoglobins designed for gene therapy of sickle cell diseaseA 46 base pair enhancer sequence within the locus activating region is required for induced expression of the gamma-globin gene during erythroid differentiation.A dominant chromatin-opening activity in 5' hypersensitive site 3 of the human beta-globin locus control region.DNaseI hypersensitive sites 1, 2 and 3 of the human beta-globin dominant control region direct position-independent expressionTwo tissue-specific factors bind the erythroid promoter of the human porphobilinogen deaminase geneStructure and function of the enhancer 3' to the human A gamma globin geneMutation of gene-proximal regulatory elements disrupts human epsilon-, gamma-, and beta-globin expression in yeast artificial chromosome transgenic miceA common protein binds to two silencers 5' to the human beta-globin gene.The human beta-globin promoter; nuclear protein factors and erythroid specific induction of transcription.Regulation of erythroid cell-specific gene expression during erythropoiesis.Myelin basic protein gene contains separate enhancers for oligodendrocyte and Schwann cell expressionThe murine myeloperoxidase promoter contains several functional elements, one of which binds a cell type-restricted transcription factor, myeloid nuclear factor 1 (MyNF1).Identification and characterization of a beta-globin promoter-binding factor from murine erythroleukemia cellsTranscriptional role of a conserved GATA-1 site in the human epsilon-globin gene promoterMultiple, compensatory regulatory elements specify spermatocyte-specific expression of the Drosophila melanogaster hsp26 gene.Roles of fetal G gamma-globin promoter elements and the adult beta-globin 3' enhancer in the stage-specific expression of globin genes.Negative regulation of globin gene expression during megakaryocytic differentiation of a human erythroleukemic cell line.Beta-globin enhancers target expression of a heterologous gene to erythroid tissues of transgenic mice.DNA sequences involved in transcriptional regulation of the mouse beta-globin promoter in murine erythroleukemia cells.In vivo selection of genetically modified erythroblastic progenitors leads to long-term correction of beta-thalassemia.Differential regulation of endogenous and transduced beta-globin genes during infection of erythroid cells with a herpes simplex virus type 1 recombinant.Regulated expression of human alpha- and beta-globin genes in transient heterokaryonsHuman GATA-3 trans-activation, DNA-binding, and nuclear localization activities are organized into distinct structural domains.Distinct negative regulation of the human embryonic globin genes zeta and epsilon.Inducibility of the HS II enhancer depends on binding of an erythroid specific nuclear protein.
P2860
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P2860
The human beta-globin gene contains multiple regulatory regions: identification of one promoter and two downstream enhancers.
description
1988 nî lūn-bûn
@nan
1988年の論文
@ja
1988年論文
@yue
1988年論文
@zh-hant
1988年論文
@zh-hk
1988年論文
@zh-mo
1988年論文
@zh-tw
1988年论文
@wuu
1988年论文
@zh
1988年论文
@zh-cn
name
The human beta-globin gene con ...... and two downstream enhancers.
@ast
The human beta-globin gene con ...... and two downstream enhancers.
@en
type
label
The human beta-globin gene con ...... and two downstream enhancers.
@ast
The human beta-globin gene con ...... and two downstream enhancers.
@en
prefLabel
The human beta-globin gene con ...... and two downstream enhancers.
@ast
The human beta-globin gene con ...... and two downstream enhancers.
@en
P2093
P2860
P1433
P1476
The human beta-globin gene con ...... r and two downstream enhancers
@en
P2093
P2860
P304
P356
10.1002/J.1460-2075.1988.TB02824.X
P407
P577
1988-02-01T00:00:00Z