Association of INT2/HST1 coamplification in primary breast cancer with hormone-dependent phenotype and poor prognosis - Wikidata - awgldk - TriplyDB

Association of INT2/HST1 coamplification in primary breast cancer with hormone-dependent phenotype and poor prognosis

Association of INT2/HST1 coamplification in primary breast cancer with hormone-dependent phenotype and poor prognosis

http://www.wikidata.org/entity/Q35982544

about

Csk homologous kinase (CHK) and ErbB-2 interactions are directly coupled with CHK negative growth regulatory function in breast cancer The product of the EMS1 gene, amplified and overexpressed in human carcinomas, is homologous to a v-src substrate and is located in cell-substratum contact sites Cyclin D1 stimulation of estrogen receptor transcriptional activity independent of cdk4 Amplification of Cellular Oncogenes in Solid Tumors Cyclin D1 in breast cancer Characterization of the EMS1 gene and its product, human Cortactin Amplified region of chromosome band 11q13 in breast and squamous cell carcinomas encompasses three CpG islands telomeric of FGF3, including the expressed gene EMS1 Brk, a breast tumor-derived non-receptor protein-tyrosine kinase, sensitizes mammary epithelial cells to epidermal growth factor Csk homologous kinase, a novel signaling molecule, directly associates with the activated ErbB-2 receptor in breast cancer cells and inhibits their proliferation Cyclin D1 amplification and expression in human breast carcinoma: correlation with histological prognostic markers and oestrogen receptor expression.Expression of int-2 oncogene in Kaposi's sarcoma lesions.Regulation of the functional interaction between cyclin D1 and the estrogen receptor.ANO1 amplification and expression in HNSCC with a high propensity for future distant metastasis and its functions in HNSCC cell lines.Role of proto-oncogene activation in carcinogenesis.Cyclin D1, EMS1 and 11q13 amplification in breast cancer.Cyclin D1 induction in breast cancer cells shortens G1 and is sufficient for cells arrested in G1 to complete the cell cycle.Genetic aberrations in hypodiploid breast cancer: frequent loss of chromosome 4 and amplification of cyclin D1 oncogene Amplification of CCND1 and expression of its protein product, cyclin D1, in ductal carcinoma in situ of the breast.Somatic mutations and human breast cancer. A status report.Analysis of the IGF-II receptor gene copy number in breast carcinoma.Loss of heterozygosity at chromosome 11 in breast cancer: association of prognostic factors with genetic alterations.A clinicopathological study on overexpression of cyclin D1 and of p53 in a series of 248 patients with operable breast cancer Indications for cytostatic therapy in metastatic breast cancer.Estrogen-dependent cyclin E-cdk2 activation through p21 redistribution.Prognostic value of CCND1 gene status in sporadic breast tumours, as determined by real-time quantitative PCR assays Gene products of chromosome 11q and their association with CCND1 gene amplification and tamoxifen resistance in premenopausal breast cancer.The 11q13-q14 amplicon: clinicopathological correlations and potential drivers.Steroid hormones and risk of breast cancer.Theory and methodology of evaluating genetic alterations.Cyclin D1 and human neoplasia Linkage map of a region of human chromosome band 11q13 amplified in breast and squamous cell tumors.Overexpression of cyclin D1 correlates with early recurrence in superficial bladder cancers.c-myc amplification is an independent prognostic factor in postmenopausal breast cancer.High-resolution genomic analysis of the 11q13 amplicon in breast cancers identifies synergy with 8p12 amplification, involving the mTOR targets S6K2 and 4EBP1.Identification of high-risk breast cancer patients from genetic changes of their tumors.Amplifications of oncogene erbB-2 and chromosome 20q in breast cancer determined by differentially competitive polymerase chain reaction.Oncogenic collaboration of the cyclin D1 (PRAD1, bcl-1) gene with a mutated p53 and an activated ras oncogene in neoplastic transformation.Patterns of dna amplification at band q13 of chromosome 11 in human breast cancer Comprehensive genome and transcriptome analysis of the 11q13 amplicon in human oral cancer and synteny to the 7F5 amplicon in murine oral carcinoma Selection of Primary Breast Cancer Patients for Adjuvant Endocrine Therapy – is Oestrogen Receptor Alone Adequate?

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P2860

Association of INT2/HST1 coamplification in primary breast cancer with hormone-dependent phenotype and poor prognosis

http://www.wikidata.org/entity/Q35982544

description

1991 nî lūn-bûn

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1991年の論文

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1991年論文

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1991年論文

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1991年論文

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1991年論文

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1991年論文

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1991年论文

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1991年论文

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1991年论文

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name

Association of INT2/HST1 coamp ...... t phenotype and poor prognosis

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Association of INT2/HST1 coamp ...... t phenotype and poor prognosis

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type

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Association of INT2/HST1 coamp ...... t phenotype and poor prognosis

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Association of INT2/HST1 coamp ...... t phenotype and poor prognosis

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prefLabel

Association of INT2/HST1 coamp ...... t phenotype and poor prognosis

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Association of INT2/HST1 coamp ...... t phenotype and poor prognosis

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British Journal of Cancer

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Association of INT2/HST1 coamp ...... t phenotype and poor prognosis

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P2093

A Borg

http://www.w3.org/2001/XMLSchema#string

D Killander

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G M Clark

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H Sigurdsson

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M Fernö

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S A Fuqua

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W L McGurie

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P2860

Sequence organization of the human int-2 gene and its expression in teratocarcinoma cells

Genomic sequence of hst, a transforming gene encoding a protein homologous to fibroblast growth factors and the int-2-encoded protein

The progesterone receptor gene maps to human chromosome band 11q13, the site of the mammary oncogene int-2

Characterization and chromosome assignment of the human homolog of int-2, a potential proto-oncogene

Detection of specific sequences among DNA fragments separated by gel electrophoresis

Molecular cloning of the chromosomal breakpoint of B-cell lymphomas and leukemias with the t(11;14) chromosome translocation

An oncogene isolated by transfection of Kaposi's sarcoma DNA encodes a growth factor that is a member of the FGF family

Two homologous oncogenes, HST1 and INT2, are closely located in human genome

Chromosomal localization of the hst oncogene and its co-amplification with the int.2 oncogene in a human melanoma

Human HST1 (HSTF1) gene maps to chromosome band 11q13 and coamplifies with the INT2 gene in human cancer

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136-142

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10.1038/BJC.1991.28

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1008652291

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1971653

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