Identification of a tetratricopeptide repeat-like domain in the nicastrin subunit of γ-secretase using synthetic antibodies - Wikidata - awgldk - TriplyDB

Identification of a tetratricopeptide repeat-like domain in the nicastrin subunit of γ-secretase using synthetic antibodies

Identification of a tetratricopeptide repeat-like domain in the nicastrin subunit of γ-secretase using synthetic antibodies

http://www.wikidata.org/entity/Q36001311

about

Structural biology of presenilin 1 complexes Conformational states and recognition of amyloidogenic peptides of human insulin-degrading enzyme Complex regulation of γ-secretase: from obligatory to modulatory subunits Aromatic claw: A new fold with high aromatic content that evades structural prediction.An interactive network of elastase, secretases, and PAR-2 protein regulates CXCR1 receptor surface expression on neutrophils.Anti-nicastrin monoclonal antibodies elicit pleiotropic anti-tumour pharmacological effects in invasive breast cancer cells.Generating conformation-specific synthetic antibodies to trap proteins in selected functional states A synthetic antibody fragment targeting nicastrin affects assembly and trafficking of γ-secretase.Recombinant antibodies to histone post-translational modifications The dynamic conformational landscape of gamma-secretase.Substrate recruitment of γ-secretase and mechanism of clinical presenilin mutations revealed by photoaffinity mapping.Generating Conformation and Complex-Specific Synthetic Antibodies.Retention in endoplasmic reticulum 1 (RER1) modulates amyloid-β (Aβ) production by altering trafficking of γ-secretase and amyloid precursor protein (APP).Evidence That the "Lid" Domain of Nicastrin Is Not Essential for Regulating γ-Secretase Activity.Structural and mechanistic principles of intramembrane proteolysis--lessons from rhomboids.Structural biology of presenilins and signal peptide peptidases.Physiological and pathological roles of the γ-secretase complex.Analysis of nicastrin gene phylogeny and expression in zebrafish.High-efficient production and biophysical characterisation of nicastrin and its interaction with APPC100 Conditional inactivation of nicastrin restricts amyloid deposition in an Alzheimer's disease mouse model.Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme.Important functional role of residue x of the presenilin GxGD protease active site motif for APP substrate cleavage specificity and substrate selectivity of γ-secretase.

P2860

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P2860

Identification of a tetratricopeptide repeat-like domain in the nicastrin subunit of γ-secretase using synthetic antibodies

http://www.wikidata.org/entity/Q36001311

description

2012 nî lūn-bûn

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2012年の論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年论文

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2012年论文

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2012年论文

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name

Identification of a tetratrico ...... ase using synthetic antibodies

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Identification of a tetratrico ...... ase using synthetic antibodies

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Identification of a tetratrico ...... ase using synthetic antibodies

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Identification of a tetratrico ...... ase using synthetic antibodies

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prefLabel

Identification of a tetratrico ...... ase using synthetic antibodies

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Identification of a tetratrico ...... ase using synthetic antibodies

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P1433

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P356

PNAS.1202691109

P1433

Proceedings of the National Academy of Sciences of the United States of America

P1476

Identification of a tetratrico ...... ase using synthetic antibodies

@en

P2093

Akiko Koide

http://www.w3.org/2001/XMLSchema#string

Brenda Leung

http://www.w3.org/2001/XMLSchema#string

Georgia Dolios

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Guoqing Lin

http://www.w3.org/2001/XMLSchema#string

Kwangwook Ahn

http://www.w3.org/2001/XMLSchema#string

Marcin Paduch

http://www.w3.org/2001/XMLSchema#string

Robert J Hoey

http://www.w3.org/2001/XMLSchema#string

Rong Wang

http://www.w3.org/2001/XMLSchema#string

Sangram S Sisodia

http://www.w3.org/2001/XMLSchema#string

Takeshi Ikeuchi

http://www.w3.org/2001/XMLSchema#string

P2860

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

Human Rer1 is localized to the Golgi apparatus and complements the deletion of the homologous Rer1 protein of Saccharomyces cerevisiae

Presenilin and nicastrin regulate each other and determine amyloid beta-peptide production via complex formation

Nicastrin is critical for stability and trafficking but not association of other presenilin/gamma-secretase components.

Structure of TPR domain-peptide complexes: critical elements in the assembly of the Hsp70-Hsp90 multichaperone machine

High-throughput generation of synthetic antibodies from highly functional minimalist phage-displayed libraries

Allosteric control of ligand-binding affinity using engineered conformation-specific effector proteins

Engineering of recombinant crystallization chaperones

Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

Gamma-secretase composed of PS1/Pen2/Aph1a can cleave notch and amyloid precursor protein in the absence of nicastrin

P304

8534-8539

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scholarly article

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10.1073/PNAS.1202691109

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109

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3365189

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