about
Transmembrane receptor DCC associates with protein synthesis machinery and regulates translationThe mTOR signalling pathway in human cancerRegulation of mTOR complex 1 (mTORC1) by raptor Ser863 and multisite phosphorylationLeucine and mTORC1: a complex relationshipCrystal structure of the yeast TSC1 core domain and implications for tuberous sclerosis pathological mutationsMetabolic regulation of manganese superoxide dismutase expression via essential amino acid deprivationInhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancerd4eBP acts downstream of both dTOR and dFoxo to modulate cardiac functional aging in Drosophila.4.4 Å Resolution Cryo-EM structure of human mTOR Complex 1Epigenetic activation of a subset of mRNAs by eIF4E explains its effects on cell proliferationAnalysis of mTOR signaling by the small G-proteins, Rheb and RhebL1.Advanced gynecologic malignancies treated with a combination of the VEGF inhibitor bevacizumab and the mTOR inhibitor temsirolimus.Chemical genetics of rapamycin-insensitive TORC2 in S. cerevisiae.The late endosome is essential for mTORC1 signalingRheb GTPase controls apoptosis by regulating interaction of FKBP38 with Bcl-2 and Bcl-XLRapamycin extends maximal lifespan in cancer-prone mice.Luteinizing hormone stimulates mammalian target of rapamycin signaling in bovine luteal cells via pathways independent of AKT and mitogen-activated protein kinase: modulation of glycogen synthase kinase 3 and AMP-activated protein kinaseIntracellular parasitism with Toxoplasma gondii stimulates mammalian-target-of-rapamycin-dependent host cell growth despite impaired signalling to S6K1 and 4E-BP1.The effect of rapamycin on bone growth in rabbits.Avian reovirus nonstructural protein p17-induced G(2)/M cell cycle arrest and host cellular protein translation shutoff involve activation of p53-dependent pathways.Akt substrate TBC1D1 regulates GLUT1 expression through the mTOR pathway in 3T3-L1 adipocytesCalcineurin inhibitor-induced and Ras-mediated overexpression of VEGF in renal cancer cells involves mTOR through the regulation of PRAS40The complexes of mammalian target of rapamycin.Human chorionic gonadotropin stimulates theca-interstitial cell proliferation and cell cycle regulatory proteins by a cAMP-dependent activation of AKT/mTORC1 signaling pathwayRac1 regulates the activity of mTORC1 and mTORC2 and controls cellular size.Chemopreventive efficacy of rapamycin on Peutz-Jeghers syndrome in a mouse model.Energy balance, host-related factors, and cancer progression.Rapamycin inhibits proliferation of hemangioma endothelial cells by reducing HIF-1-dependent expression of VEGF.PTEN inhibition enhances neurite outgrowth in human embryonic stem cell-derived neuronal progenitor cells.3,3'-Diindolylmethane protects against cardiac hypertrophy via 5'-adenosine monophosphate-activated protein kinase-α2Tuberous sclerosis: a GAP at the crossroads of multiple signaling pathways.Translational control of cyclins.PI3K-mTORC1 attenuates stress response by inhibiting cap-independent Hsp70 translation.Role of TOR signaling in aging and related biological processes in Drosophila melanogasterRapamycin Regulates Bleomycin-Induced Lung Damage in SP-C-Deficient MiceAssociation of bone loss with the upregulation of survival-related genes and concomitant downregulation of Mammalian target of rapamycin and osteoblast differentiation-related genes in the peripheral blood of late postmenopausal osteoporotic women.Hypoxia-induced energy stress regulates mRNA translation and cell growth.The changes of lipid metabolism in advanced renal cell carcinoma patients treated with everolimus: a new pharmacodynamic marker?Hormesis does not make sense except in the light of TOR-driven aging.Point mutations in TOR confer Rheb-independent growth in fission yeast and nutrient-independent mammalian TOR signaling in mammalian cells
P2860
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P2860
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
2004年學術文章
@zh
2004年學術文章
@zh-hant
name
mTOR, translational control and human disease.
@ast
mTOR, translational control and human disease.
@en
type
label
mTOR, translational control and human disease.
@ast
mTOR, translational control and human disease.
@en
prefLabel
mTOR, translational control and human disease.
@ast
mTOR, translational control and human disease.
@en
P1476
mTOR, translational control and human disease
@en
P2093
John Blenis
P356
10.1016/J.SEMCDB.2004.11.005
P577
2004-12-31T00:00:00Z