about
Targeted mutations of Bacillus anthracis dihydrofolate reductase condense complex structure−activity relationshipsStructure-Guided Development of Efficacious Antifungal Agents Targeting Candida glabrata Dihydrofolate ReductaseSynthesis and Evaluation of α-Thymidine Analogues as Novel AntimalarialsThe crystal structure of Leishmania major N5,N10-methylenetetrahydrofolate dehydrogenase/cyclohydrolase and assessment of a potential drug targetMolecular evidence of increased resistance to anti-folate drugs in Plasmodium falciparum in North-East India: a signal for potential failure of artemisinin plus sulphadoxine-pyrimethamine combination therapyMetabolic Needs and Capabilities of Toxoplasma gondii through Combined Computational and Experimental AnalysisTargeting purine and pyrimidine metabolism in human apicomplexan parasitesProbing the structure of Leishmania major DHFR TS and structure based virtual screening of peptide library for the identification of anti-leishmanial leads.Evaluation of high efficiency gene knockout strategies for Trypanosoma cruziToward the design of mutation-resistant enzyme inhibitors: further evaluation of the substrate envelope hypothesis.Binding modes of 2,4-diaminoquinazoline and 2,4-diaminopteridine analogs to P. falciparum dihydrofolate reductase enzyme: Molecular docking studies.Structure-based approach to the development of potent and selective inhibitors of dihydrofolate reductase from cryptosporidium.Evaluation of the activities of pyrimethamine analogs against Plasmodium vivax and Plasmodium falciparum dihydrofolate reductase-thymidylate synthase using in vitro enzyme inhibition and bacterial complementation assays.Targeting the erythrocytic and liver stages of malaria parasites with s-triazine-based hybrids.Purine and pyrimidine pathways as targets in Plasmodium falciparum.Anti-Toxoplasma Activity of 2-(Naphthalene-2-γlthiol)-1H Indole.Folate metabolism as a source of molecular targets for antimalarials.Novel non-active site inhibitor of Cryptosporidium hominis TS-DHFR identified by a virtual screenTowards new antifolates targeting eukaryotic opportunistic infectionsDirect Effect of Two Naphthalene-Sulfonyl-Indole Compounds on Toxoplasma gondii TachyzoiteStructure-activity relationship and comparative docking studies for cycloguanil analogs as PfDHFR-TS inhibitors.Review of Experimental Compounds Demonstrating Anti-Toxoplasma Activity.Design, synthesis, and biological evaluation of classical and nonclassical 2-amino-4-oxo-5-substituted-6-methylpyrrolo[3,2-d]pyrimidines as dual thymidylate synthase and dihydrofolate reductase inhibitors.Dihydrofolate reductase as a therapeutic target for infectious diseases: opportunities and challenges.Pyrimethamine-loaded lipid-core nanocapsules to improve drug efficacy for the treatment of toxoplasmosis.Discovery of Potent and Selective Leads against Toxoplasma gondii Dihydrofolate Reductase via Structure-Based Design.Substrate channeling between the human dihydrofolate reductase and thymidylate synthase.Pharmacoinformatic Study on the Selective Inhibition of the Protozoan Dihydrofolate Reductase Enzymes.Structural and Dynamics Perspectives on the Binding of Substrate and Inhibitors in Mycobacterium tuberculosis DHFRQuantitative structure-activity relationships for cycloguanil analogs as PfDHFR inhibitors using mathematical molecular descriptors.A common feature-based 3D-pharmacophore model generation and virtual screening: identification of potential PfDHFR inhibitors.Evaluating the high-throughput screening computations.Prevalence of mutations linked to antimalarial resistance in Plasmodium falciparum from Chhattisgarh, Central India: A malaria elimination point of view.Insight into the molecular mechanism about lowered dihydrofolate binding affinity to dihydrofolate reductase-like 1 (DHFRL1).Fatal Intoxications Due to Administration of Isosorbide Tablets Contaminated with Pyrimethamine.Molecular dynamics of interactions between rigid and flexible antifolates and dihydrofolate reductase from pyrimethamine-sensitive and pyrimethamine-resistant Plasmodium falciparum.Directed evolution of trimethoprim resistance in Escherichia coli.The search for new DHFR inhibitors: a review of patents, January 2001 – February 2005
P2860
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P2860
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
Targeting DHFR in parasitic protozoa.
@ast
Targeting DHFR in parasitic protozoa.
@en
type
label
Targeting DHFR in parasitic protozoa.
@ast
Targeting DHFR in parasitic protozoa.
@en
prefLabel
Targeting DHFR in parasitic protozoa.
@ast
Targeting DHFR in parasitic protozoa.
@en
P1433
P1476
Targeting DHFR in parasitic protozoa.
@en
P2093
Amy C Anderson
P304
P356
10.1016/S1359-6446(04)03308-2
P577
2005-01-01T00:00:00Z