p53-independent activities of MDM2 and their relevance to cancer therapy.
about
Tumor suppression in skin and other tissues via cross-talk between vitamin D- and p53-signalingCrystal Structures of Human MdmX (HdmX) in Complex with p53 Peptide Analogues Reveal Surprising Conformational ChangesMDM2 promotes proteasomal degradation of p21Waf1 via a conformation change.The Mdm2-p53 relationship evolves: Mdm2 swings both ways as an oncogene and a tumor suppressor.MDM2 mediates ubiquitination and degradation of activating transcription factor 3Identification of a new class of MDM2 inhibitor that inhibits growth of orthotopic pancreatic tumors in mice.A quantitative LC-MS/MS method for determination of SP-141, a novel pyrido[b]indole anticancer agent, and its application to a mouse PK study.Protein-protein interactions for cancer therapyE3 ubiquitin ligases as cancer targets and biomarkers.Inhibition of MDM2 by nilotinib contributes to cytotoxicity in both Philadelphia-positive and negative acute lymphoblastic leukemiaInhibition of MDM2 homodimerization by XIAP IRES stabilizes MDM2, influencing cancer cell survival.MDM2 regulates MYCN mRNA stabilization and translation in human neuroblastoma cellsIdentification of a new class of natural product MDM2 inhibitor: In vitro and in vivo anti-breast cancer activities and target validation.Network modeling of MDM2 inhibitor-oxaliplatin combination reveals biological synergy in wt-p53 solid tumors.Pre-apoptotic response to therapeutic DNA damage involves protein modulation of Mcl-1, Hdm2 and Flt3 in acute myeloid leukemia cells.p53 and MDM2 are involved in the regulation of osteocalcin gene expression.The oncoprotein HBXIP modulates the feedback loop of MDM2/p53 to enhance the growth of breast cancer.Identification of functional DNA variants in the constitutive promoter region of MDM2Vitamin D directly regulates Mdm2 gene expression in osteoblasts.Targets and strategies for T-cell based vaccines in patients with B-cell chronic lymphocytic leukemia.Coping with stress: multiple ways to activate p53.Identification of a Small Molecule That Overcomes HdmX-Mediated Suppression of p53.p53-independent mechanisms regulate the P2-MDM2 promoter in adult astrocytic tumoursIn vitro and in vivo anticancer activity of novel synthetic makaluvamine analogues.Triptolide has anticancer and chemosensitization effects by down-regulating Akt activation through the MDM2/REST pathway in human breast cancer.Patented small molecule inhibitors of p53-MDM2 interaction.Gossypol has anti-cancer effects by dual-targeting MDM2 and VEGF in human breast cancer.Stabilization of E2F1 protein by MDM2 through the E2F1 ubiquitination pathway.The E3 ubiquitin protein ligase MDM2 dictates all-trans retinoic acid-induced osteoblastic differentiation of osteosarcoma cells by modulating the degradation of RARα.Effects of MDM2 inhibitors on vascular endothelial growth factor-mediated tumor angiogenesis in human breast cancer.Reviving the guardian of the genome: Small molecule activators of p53.Hdm2 negatively regulates telomerase activity by functioning as an E3 ligase of hTERT.Curcumin-encapsulated MePEG/PCL diblock copolymeric micelles: a novel controlled delivery vehicle for cancer therapy.Novel ginsenosides 25-OH-PPD and 25-OCH3-PPD as experimental therapy for pancreatic cancer: anticancer activity and mechanisms of actionMDM2 chaperones the p53 tumor suppressor.Nutlin-3 preferentially sensitises wild-type p53-expressing cancer cells to DR5-selective TRAIL over rhTRAIL.Molecular chaperones in the acquisition of cancer cell chemoresistance with mutated TP53 and MDM2 up-regulation.Contribution of ATM and ATR kinase pathways to p53-mediated response in etoposide and methyl methanesulfonate induced DNA damage.MDM2 SNP309 and p53 Arg72Pro in cutaneous melanoma: association between SNP309 GG genotype and tumor Breslow thickness.Natural products targeting the p53-MDM2 pathway and mutant p53: Recent advances and implications in cancer medicine
P2860
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P2860
p53-independent activities of MDM2 and their relevance to cancer therapy.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
p53-independent activities of MDM2 and their relevance to cancer therapy.
@ast
p53-independent activities of MDM2 and their relevance to cancer therapy.
@en
type
label
p53-independent activities of MDM2 and their relevance to cancer therapy.
@ast
p53-independent activities of MDM2 and their relevance to cancer therapy.
@en
prefLabel
p53-independent activities of MDM2 and their relevance to cancer therapy.
@ast
p53-independent activities of MDM2 and their relevance to cancer therapy.
@en
P356
P1476
p53-independent activities of MDM2 and their relevance to cancer therapy.
@en
P2093
Ruiwen Zhang
Zhuo Zhang
P356
10.2174/1568009053332618
P577
2005-02-01T00:00:00Z