Continuous fat oxidation in acetyl-CoA carboxylase 2 knockout mice increases total energy expenditure, reduces fat mass, and improves insulin sensitivity - Wikidata - awgldk - TriplyDB

Continuous fat oxidation in acetyl-CoA carboxylase 2 knockout mice increases total energy expenditure, reduces fat mass, and improves insulin sensitivity

Continuous fat oxidation in acetyl-CoA carboxylase 2 knockout mice increases total energy expenditure, reduces fat mass, and improves insulin sensitivity

http://www.wikidata.org/entity/Q36082167

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Reversal of hypertriglyceridemia, fatty liver disease, and insulin resistance by a liver-targeted mitochondrial uncoupler Gene knockout of Acc2 has little effect on body weight, fat mass, or food intake An Overview of Murine High Fat Diet as a Model for Type 2 Diabetes Mellitus The Role of Organelle Stresses in Diabetes Mellitus and Obesity: Implication for Treatment Does Diacylglycerol Accumulation in Fatty Liver Disease Cause Hepatic Insulin Resistance?Mitochondrial fatty acid oxidation in obesity Structure and function of biotin-dependent carboxylases Novel roles of holocarboxylase synthetase in gene regulation and intermediary metabolism Structure-guided Development of Specific Pyruvate Dehydrogenase Kinase Inhibitors Targeting the ATP-binding Pocket Reduced heart size and increased myocardial fuel substrate oxidation in ACC2 mutant mice TCF7L2 modulates glucose homeostasis by regulating CREB- and FoxO1-dependent transcriptional pathway in the liver Acute or chronic upregulation of mitochondrial fatty acid oxidation has no net effect on whole-body energy expenditure or adiposity.Muscle lipogenesis balances insulin sensitivity and strength through calcium signaling.QTLs of factors of the metabolic syndrome and echocardiographic phenotypes: the hypertension genetic epidemiology network study PGC-1alpha negatively regulates hepatic FGF21 expression by modulating the heme/Rev-Erb(alpha) axis.Recombinant yeast screen for new inhibitors of human acetyl-CoA carboxylase 2 identifies potential drugs to treat obesity.Treatment with the 3-ketoacyl-CoA thiolase inhibitor trimetazidine does not exacerbate whole-body insulin resistance in obese mice.Fish oil and krill oil supplementations differentially regulate lipid catabolic and synthetic pathways in mice.Mice lacking hepatic lipase are lean and protected against diet-induced obesity and hepatic steatosis Abrogating monoacylglycerol acyltransferase activity in liver improves glucose tolerance and hepatic insulin signaling in obese mice.Lipid oversupply, selective insulin resistance, and lipotoxicity: molecular mechanisms In vitro palmitate treatment of myotubes from postmenopausal women leads to ceramide accumulation, inflammation and affected insulin signaling.Genetic control of de novo lipogenesis: role in diet-induced obesity Progressive adaptation of hepatic ketogenesis in mice fed a high-fat diet.Metabolic syndrome and insulin resistance: underlying causes and modification by exercise training.A diurnal serum lipid integrates hepatic lipogenesis and peripheral fatty acid use.Diacylglycerol-mediated insulin resistance.Carnitine Palmitoyltransferase 1b Deficiency Protects Mice from Diet-Induced Insulin Resistance Lipid-induced insulin resistance: unravelling the mechanism.Chemical-genetic induction of Malonyl-CoA decarboxylase in skeletal muscle.Soraphen A, an inhibitor of acetyl CoA carboxylase activity, interferes with fatty acid elongation.Mitochondrial GTP insensitivity contributes to hypoglycemia in hyperinsulinemia hyperammonemia by inhibiting glucagon release.Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin.Mitochondrial dysfunction and insulin resistance: an update.AMPK and insulin action--responses to ageing and high fat diet.Abrogation of growth hormone secretion rescues fatty liver in mice with hepatocyte-specific deletion of JAK2.CYP2J2 attenuates metabolic dysfunction in diabetic mice by reducing hepatic inflammation via the PPARγ.AMPK inhibition in health and disease.CrbpI modulates glucose homeostasis and pancreas 9-cis-retinoic acid concentrations.Insulin resistance and white adipose tissue inflammation are uncoupled in energetically challenged Fsp27-deficient mice.

P2860

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P2860

Continuous fat oxidation in acetyl-CoA carboxylase 2 knockout mice increases total energy expenditure, reduces fat mass, and improves insulin sensitivity

http://www.wikidata.org/entity/Q36082167

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2007 nî lūn-bûn

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Continuous fat oxidation in ac ...... d improves insulin sensitivity

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Proceedings of the National Academy of Sciences of the United States of America

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Continuous fat oxidation in ac ...... d improves insulin sensitivity

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Alberto Distefano

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Ameya Kulkarni

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Cheol Soo Choi

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Dongyan Zhang

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Gary W Cline

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Richard M Reznick

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Salih J Wakil

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Sheene Kim

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Yu-Jin Hwang

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Zhen-Xiang Liu

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P2860

Cloning of human acetyl-CoA carboxylase beta promoter and its regulation by muscle regulatory factors

Mechanism of activation of protein kinase B by insulin and IGF-1

Mutant mice lacking acetyl-CoA carboxylase 1 are embryonically lethal

Acetyl-CoA carboxylase 2 mutant mice are protected against obesity and diabetes induced by high-fat/high-carbohydrate diets

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus

Continuous fatty acid oxidation and reduced fat storage in mice lacking acetyl-CoA carboxylase 2

Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance

Contrasting effects of fish oil and safflower oil on hepatic peroxisomal and tissue lipid content

Glucose and fat metabolism in adipose tissue of acetyl-CoA carboxylase 2 knockout mice

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42

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104

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Gerald I. Shulman

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Lutfi Abu-Elheiga

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5920723

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