Pharmacogenetics and anti-arrhythmic drug therapy: a theoretical investigation.
about
Computational medicine: translating models to clinical careSodium channel molecular conformations and antiarrhythmic drug affinityBridging scales through multiscale modeling: a case study on protein kinase AComputer-based prediction of the drug proarrhythmic effect: problems, issues, known and suspected challengesComputational cardiology: how computer simulations could be used to develop new therapies and advance existing onesImages as drivers of progress in cardiac computational modelling.Cardiac models in drug discovery and development: a review.Targeting intracellular calcium cycling in catecholaminergic polymorphic ventricular tachycardia: a theoretical investigation.Models of cardiac excitation-contraction coupling in ventricular myocytesIntegrative modeling of the cardiac ventricular myocyte.Kinetic model for NS1643 drug activation of WT and L529I variants of Kv11.1 (hERG1) potassium channel.Mechanisms of atrial-selective block of Na⁺ channels by ranolazine: I. Experimental analysis of the use-dependent blockKinetic properties of the cardiac L-type Ca2+ channel and its role in myocyte electrophysiology: a theoretical investigation.A case for pharmacogenomics in management of cardiac arrhythmias.The virtual heart as a platform for screening drug cardiotoxicity.A mathematical model for active contraction in healthy and failing myocytes and left ventricles.Application of cardiac electrophysiology simulations to pro-arrhythmic safety testing.Probing kinetic drug binding mechanism in voltage-gated sodium ion channel: open state versus inactive state blockers.Modeling subunit cooperativity in opening of tetrameric ion channels.The cardiac persistent sodium current: an appealing therapeutic target?Computational approaches to understand cardiac electrophysiology and arrhythmias.Re-evaluating the efficacy of beta-adrenergic agonists and antagonists in long QT-3 syndrome through computational modelling.Identification of Ikr kinetics and drug binding in native myocytes.Dynamical characterization of inactivation path in voltage-gated Na(+) ion channel by non-equilibrium response spectroscopy.Computational tools to investigate genetic cardiac channelopathies.In silico assessment of drug safety in human heart applied to late sodium current blockersUsing computational modeling to predict arrhythmogenesis and antiarrhythmic therapy.Multiscale Modeling in the Clinic: Drug Design and DevelopmentRevealing the Concealed Nature of Long-QT Type 3 Syndrome.Molecular Pathophysiology of Congenital Long QT Syndrome.Computational Models for Predictive Cardiac Ion Channel Pharmacology.Protein conformational plasticity and complex ligand-binding kinetics explored by atomistic simulations and Markov models.Models of excitation-contraction coupling in cardiac ventricular myocytes.Computational cardiology: the heart of the matter.Simulations of complex and microscopic models of cardiac electrophysiology powered by multi-GPU platforms.Protein-peptide association kinetics beyond the seconds timescale from atomistic simulationsA novel computational model of the human ventricular action potential and Ca transient.Simulation of the effects of moderate stimulation/inhibition of the β1-adrenergic signaling system and its components in mouse ventricular myocytes.A computational model of Purkinje fibre single cell electrophysiology: implications for the long QT syndrome.Impact of ionic current variability on human ventricular cellular electrophysiology.
P2860
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P2860
Pharmacogenetics and anti-arrhythmic drug therapy: a theoretical investigation.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Pharmacogenetics and anti-arrhythmic drug therapy: a theoretical investigation.
@ast
Pharmacogenetics and anti-arrhythmic drug therapy: a theoretical investigation.
@en
type
label
Pharmacogenetics and anti-arrhythmic drug therapy: a theoretical investigation.
@ast
Pharmacogenetics and anti-arrhythmic drug therapy: a theoretical investigation.
@en
prefLabel
Pharmacogenetics and anti-arrhythmic drug therapy: a theoretical investigation.
@ast
Pharmacogenetics and anti-arrhythmic drug therapy: a theoretical investigation.
@en
P2093
P2860
P1476
Pharmacogenetics and anti-arrhythmic drug therapy: a theoretical investigation.
@en
P2093
Colleen E Clancy
Yoram Rudy
Zheng I Zhu
P2860
P304
P356
10.1152/AJPHEART.00312.2006
P577
2006-09-22T00:00:00Z