Oncogenic KRas suppresses inflammation-associated senescence of pancreatic ductal cells
about
Targeting inflammation in pancreatic cancer: Clinical translationHijacking the Hexosamine Biosynthetic Pathway to Promote EMT-Mediated Neoplastic PhenotypesEpithelial-mesenchymal plasticity in carcinoma metastasisEMT or EMT-Promoting Transcription Factors, Where to Focus the Light?Exploiting inflammation for therapeutic gain in pancreatic cancerRegulation of Cellular Identity in CancerEGF receptor is required for KRAS-induced pancreatic tumorigenesisKRAS, BRAF genotyping reveals genetic heterogeneity of ovarian borderline tumors and associated implants.RAGE gene deletion inhibits the development and progression of ductal neoplasia and prolongs survival in a murine model of pancreatic cancer.Oncogenic transformation of diverse gastrointestinal tissues in primary organoid cultureGenetic inactivation of the pancreatitis-inducible gene Nupr1 impairs PanIN formation by modulating Kras(G12D)-induced senescenceTwist1 suppresses senescence programs and thereby accelerates and maintains mutant Kras-induced lung tumorigenesis.Induced cancer stem-like cells as a model for biological screening and discovery of agents targeting phenotypic traits of cancer stem cell.Ras-related tumorigenesis is suppressed by BNIP3-mediated autophagy through inhibition of cell proliferation.Bmi1 is required for the initiation of pancreatic cancer through an Ink4a-independent mechanism.Cellular features of senescence during the evolution of human and murine ductal pancreatic cancerAutophagy in pancreatic cancer pathogenesis and treatmentInteractions between wild-type and mutant Ras genes in lung and skin carcinogenesis.Modeling pancreatic cancer with organoidsOncogenic Kras-induced GM-CSF production promotes the development of pancreatic neoplasiaInhibition of pancreatic carcinoma by homo- and heterocombinations of antibodies against EGF-receptor and its kin HER2/ErbB-2Isoprenylcysteine carboxylmethyltransferase deficiency exacerbates KRAS-driven pancreatic neoplasia via Notch suppression.KRas, ROS and the initiation of pancreatic cancerKRAS(G12D)- and BRAF(V600E)-induced transformation of murine pancreatic epithelial cells requires MEK/ERK-stimulated IGF1R signaling.The Aurora kinase A inhibitor TC-A2317 disrupts mitotic progression and inhibits cancer cell proliferation.Senescence-associated SIN3B promotes inflammation and pancreatic cancer progression.Never-ageing cellular senescenceTranslational control of cell fate: from integration of environmental signals to breaching anticancer defense.Involvement of inflammatory factors in pancreatic carcinogenesis and preventive effects of anti-inflammatory agents.Roles for KRAS in pancreatic tumor development and progression.Molecular mechanisms of oncogene-induced inflammation and inflammation-sustained oncogene activation in gastrointestinal tumors: an under-appreciated symbiotic relationship.HDAC2 promotes loss of primary cilia in pancreatic ductal adenocarcinoma.Pancreatic cancer biology and genetics from an evolutionary perspective.Inhibition of TWIST1 leads to activation of oncogene-induced senescence in oncogene-driven non-small cell lung cancer.Epithelial cell senescence: an adaptive response to pre-carcinogenic stresses?Tumor suppressor p16INK4a controls oncogenic K-Ras function in human pancreatic cancer cells.RelA regulates CXCL1/CXCR2-dependent oncogene-induced senescence in murine Kras-driven pancreatic carcinogenesisKras(G12D) induces EGFR-MYC cross signaling in murine primary pancreatic ductal epithelial cells.Presence of somatic mutations in most early-stage pancreatic intraepithelial neoplasia.Increased expression of senescence markers in cystic fibrosis airways
P2860
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P2860
Oncogenic KRas suppresses inflammation-associated senescence of pancreatic ductal cells
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
2010年论文
@zh
2010年论文
@zh-cn
name
Oncogenic KRas suppresses inflammation-associated senescence of pancreatic ductal cells
@ast
Oncogenic KRas suppresses inflammation-associated senescence of pancreatic ductal cells
@en
type
label
Oncogenic KRas suppresses inflammation-associated senescence of pancreatic ductal cells
@ast
Oncogenic KRas suppresses inflammation-associated senescence of pancreatic ductal cells
@en
prefLabel
Oncogenic KRas suppresses inflammation-associated senescence of pancreatic ductal cells
@ast
Oncogenic KRas suppresses inflammation-associated senescence of pancreatic ductal cells
@en
P2860
P1433
P1476
Oncogenic KRas suppresses inflammation-associated senescence of pancreatic ductal cells
@en
P2093
Kyoung Eun Lee
P2860
P304
P356
10.1016/J.CCR.2010.10.020
P577
2010-11-01T00:00:00Z