The structure-function dilemma of the hammerhead ribozyme.
about
Efficient ligation of the Schistosoma hammerhead ribozymeLow-magnesium, trans-cleavage activity by type III, tertiary stabilized hammerhead ribozymes with stem 1 discontinuities.Understanding nucleic acid-ion interactionsSolvent Structure and Hammerhead Ribozyme CatalysisCapturing Hammerhead Ribozyme Structures in Action by Modulating General Base CatalysisActive-Site Monovalent Cations Revealed in a 1.55-Å-Resolution Hammerhead Ribozyme StructureExploring the role of conformational heterogeneity in cis-autoproteolytic activation of ThnT.Tertiary contacts distant from the active site prime a ribozyme for catalysis.Complete RNA inverse folding: computational design of functional hammerhead ribozymesSmall self-cleaving ribozymesComputational mutagenesis studies of hammerhead ribozyme catalysis.Hammerhead redux: does the new structure fit the old biochemical data?RiboSubstrates: a web application addressing the cleavage specificities of ribozymes in designated genomes.A modern mode of activation for nucleic acid enzymes.Phylogenetic footprinting of non-coding RNA: hammerhead ribozyme sequences in a satellite DNA family of Dolichopoda cave crickets (Orthoptera, Rhaphidophoridae)The loss of a hydrogen bond: Thermodynamic contributions of a non-standard nucleotide.The hammerhead ribozyme: structure, catalysis, and gene regulationPrecise mapping of RNA tertiary structure via nanometer distance measurements with double electron-electron resonance spectroscopyComparison of mode analyses at different resolutions applied to nucleic acid systems.Active participation of Mg ion in the reaction coordinate of RNA self-cleavage catalyzed by the hammerhead ribozyme.Structure-based DNA-targeting strategies with small molecule ligands for drug discovery.Extraordinary rates of transition metal ion-mediated ribozyme catalysisVariables and strategies in development of therapeutic post-transcriptional gene silencing agentsMultifrequency Pulsed EPR Studies of Biologically Relevant Manganese(II) ComplexesGround-state coordination of a catalytic metal to the scissile phosphate of a tertiary-stabilized Hammerhead ribozyme.Improved prediction of RNA tertiary structure with insights into native state dynamics.'In-line attack' conformational effect plays a modest role in an enzyme-catalyzed RNA cleavage: a free energy simulation study.Coupling of fast and slow modes in the reaction pathway of the minimal hammerhead ribozyme cleavage.Exploring purine N7 interactions via atomic mutagenesis: the group I ribozyme as a case study.Minimal and extended hammerheads utilize a similar dynamic reaction mechanism for catalysis.Two Divalent Metal Ions and Conformational Changes Play Roles in the Hammerhead Ribozyme Cleavage Reaction.Modulation of quaternary structure and enhancement of ligand binding by the K-turn of tandem glycine riboswitches.Bridging the gap between theory and experiment to derive a detailed understanding of hammerhead ribozyme catalysis.Force Field for Mg(2+), Mn(2+), Zn(2+), and Cd(2+) Ions That Have Balanced Interactions with Nucleic Acids.Two Active Site Divalent Ions in the Crystal Structure of the Hammerhead Ribozyme Bound to a Transition State AnalogueEfficient substrate cleavage catalyzed by hammerhead ribozymes derivatized with selenium for X-ray crystallography.Role of Mg2+ in hammerhead ribozyme catalysis from molecular simulationMetal ion specificities for folding and cleavage activity in the Schistosoma hammerhead ribozymeInsight into the role of Mg in hammerhead ribozyme catalysis from X-ray crystallography and molecular dynamics simulation.RNA as a versatile and powerful platform for engineering genetic regulatory tools.
P2860
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P2860
The structure-function dilemma of the hammerhead ribozyme.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh
2005年學術文章
@zh-hant
name
The structure-function dilemma of the hammerhead ribozyme.
@ast
The structure-function dilemma of the hammerhead ribozyme.
@en
type
label
The structure-function dilemma of the hammerhead ribozyme.
@ast
The structure-function dilemma of the hammerhead ribozyme.
@en
prefLabel
The structure-function dilemma of the hammerhead ribozyme.
@ast
The structure-function dilemma of the hammerhead ribozyme.
@en
P1476
The structure-function dilemma of the hammerhead ribozyme.
@en
P2093
Kenneth F Blount
Olke C Uhlenbeck
P304
P356
10.1146/ANNUREV.BIOPHYS.34.122004.184428
P577
2005-01-01T00:00:00Z