Ultraviolet radiation triggers apoptosis of fibroblasts and skin keratinocytes mainly via the BH3-only protein Noxa.
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Noxa/Bcl-2 protein interactions contribute to bortezomib resistance in human lymphoid cellsEphA2 is an essential mediator of UV radiation-induced apoptosisPUMA, a potent killer with or without p53The signaling involving in autophagy machinery in keratinocytes and therapeutic approaches for skin diseasesDiscovery and molecular characterization of a Bcl-2-regulated cell death pathway in schistosomesGefitinib-induced killing of NSCLC cell lines expressing mutant EGFR requires BIM and can be enhanced by BH3 mimeticsIn vivo identification of solar radiation-responsive gene network: role of the p38 stress-dependent kinaseLoss of the p53/p63 regulated desmosomal protein Perp promotes tumorigenesis.Perturbation of the Bcl-2 network and an induced Noxa/Bcl-xL interaction trigger mitochondrial dysfunction after DNA damageMaximal killing of lymphoma cells by DNA damage-inducing therapy requires not only the p53 targets Puma and Noxa, but also BimEpidermal expression of neuropilin 1 protects murine keratinocytes from UVB-induced apoptosis.Absence of p53-dependent apoptosis leads to UV radiation hypersensitivity, enhanced immunosuppression and cellular senescence.Oppositional regulation of Noxa by JNK1 and JNK2 during apoptosis induced by proteasomal inhibitorsThe essential role of evasion from cell death in cancer.Enhanced contact allergen- and UVB-induced keratinocyte apoptosis in the absence of CD95/Fas/Apo-1.Phylogenetically Distant Viruses Use the Same BH3-Only Protein Puma to Trigger Bax/Bak-Dependent Apoptosis of Infected Mouse and Human Cells.BH3-only proteins in apoptosis at a glanceThe BCL-2 protein family, BH3-mimetics and cancer therapy.Bcl-2 is the target of a UV-inducible apoptosis switch and a node for UV signaling.An interconnected hierarchical model of cell death regulation by the BCL-2 familyBH3-only protein Puma contributes to death of antigen-specific T cells during shutdown of an immune response to acute viral infection.Loss of the BH3-only protein Bmf impairs B cell homeostasis and accelerates gamma irradiation-induced thymic lymphoma development.E6 proteins from low-risk human papillomavirus types 6 and 11 are able to protect keratinocytes from apoptosis via Bak degradation.Multisite phosphorylation regulates Bim stability and apoptotic activity.How important are post-translational modifications in p53 for selectivity in target-gene transcription and tumour suppression?The BH3-only protein Bik/Blk/Nbk inhibits nuclear translocation of activated ERK1/2 to mediate IFNgamma-induced cell death.What do we know about the mechanisms of elimination of autoreactive T and B cells and what challenges remain.DNA damage, apoptosis and langerhans cells--Activators of UV-induced immune tolerance.The dark side of a tumor suppressor: anti-apoptotic p53.Proapoptotic Noxa is required for particulate matter-induced cell death and lung inflammation.BRAF inhibitors suppress apoptosis through off-target inhibition of JNK signaling.Differential effects on ARF stability by normal versus oncogenic levels of c-Myc expression.The proapoptotic BH3-only, Bcl-2 family member, Puma is critical for acute ethanol-induced neuronal apoptosis.Interrogating the relevance of mitochondrial apoptosis for vertebrate development and postnatal tissue homeostasisNoxa: at the tip of the balance between life and death.hBfl-1/hNOXA Interaction Studies Provide New Insights on the Role of Bfl-1 in Cancer Cell Resistance and for the Design of Novel Anticancer Agents.Deciphering the rules of programmed cell death to improve therapy of cancer and other diseasesDeconstructing p53 transcriptional networks in tumor suppression.The role of the apoptotic machinery in tumor suppression.Cell Death Signaling.
P2860
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P2860
Ultraviolet radiation triggers apoptosis of fibroblasts and skin keratinocytes mainly via the BH3-only protein Noxa.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Ultraviolet radiation triggers ...... via the BH3-only protein Noxa.
@ast
Ultraviolet radiation triggers ...... via the BH3-only protein Noxa.
@en
type
label
Ultraviolet radiation triggers ...... via the BH3-only protein Noxa.
@ast
Ultraviolet radiation triggers ...... via the BH3-only protein Noxa.
@en
prefLabel
Ultraviolet radiation triggers ...... via the BH3-only protein Noxa.
@ast
Ultraviolet radiation triggers ...... via the BH3-only protein Noxa.
@en
P2860
P50
P356
P1476
Ultraviolet radiation triggers ...... via the BH3-only protein Noxa
@en
P2093
Andreas Villunger
Edwina Naik
P2860
P304
P356
10.1083/JCB.200608070
P407
P577
2007-02-05T00:00:00Z