Functional multivesicular bodies are required for autophagic clearance of protein aggregates associated with neurodegenerative disease.
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Dysregulation of the autophagy-endolysosomal system in amyotrophic lateral sclerosis and related motor neuron diseasesAlzheimer's disease as homeostatic responses to age-related myelin breakdownRab GTPase-activating proteins in autophagy: regulation of endocytic and autophagy pathways by direct binding to human ATG8 modifiersThe selective macroautophagic degradation of aggregated proteins requires the PI3P-binding protein AlfyChaperone-like activity of high-mobility group box 1 protein and its role in reducing the formation of polyglutamine aggregatesSCAMP5 links endoplasmic reticulum stress to the accumulation of expanded polyglutamine protein aggregates via endocytosis inhibitionThe FTLD risk factor TMEM106B and MAP6 control dendritic trafficking of lysosomesVps33b pathogenic mutations preferentially affect VIPAS39/SPE-39-positive endosomesThe HOPS complex mediates autophagosome-lysosome fusion through interaction with syntaxin 17ESCRT-III subunits Snf7-1 and Snf7-2 differentially regulate transmembrane cargos in hESC-derived human neuronsThe ESCRT complexesMembrane budding and scission by the ESCRT machinery: it's all in the neckAutophagy and pattern recognition receptors in innate immunityThe ESCRT machinery: new roles at new holesUltrastructural studies of ALS mitochondria connect altered function and permeability with defects of mitophagy and mitochondriogenesisAutophagy-Related Deubiquitinating Enzymes Involved in Health and DiseaseConverging mechanisms in ALS and FTD: disrupted RNA and protein homeostasisAutophagy modulation as a potential therapeutic target for diverse diseasesEarly etiology of Alzheimer's disease: tipping the balance toward autophagy or endosomal dysfunction?Multiple functions of the SNARE protein Snap29 in autophagy, endocytic, and exocytic trafficking during epithelial formation in Drosophila.Identification of Atypical Peri-Nuclear Multivesicular Bodies in Oxidative and Glycolytic Skeletal Muscle of Aged and Pompe's Disease Mouse Models.The endosomal protein CHARGED MULTIVESICULAR BODY PROTEIN1 regulates the autophagic turnover of plastids in ArabidopsisESCRT-II controls retinal axon growth by regulating DCC receptor levels and local protein synthesisStructural basis for sorting mechanism of p62 in selective autophagyParkinson's disease-linked human PARK9/ATP13A2 maintains zinc homeostasis and promotes α-Synuclein externalization via exosomes.Autophagosome dynamics in neurodegeneration at a glanceRetromer Ensures the Degradation of Autophagic Cargo by Maintaining Lysosome Function in DrosophilaSyntaxin 13, a genetic modifier of mutant CHMP2B in frontotemporal dementia, is required for autophagosome maturationAtg8: an autophagy-related ubiquitin-like protein familyRegulation of endocytic sorting by ESCRT-DUB-mediated deubiquitinationThe ubiquitin-proteasome system in spongiform degenerative disordersMice deficient in Epg5 exhibit selective neuronal vulnerability to degenerationLoss of C9ORF72 impairs autophagy and synergizes with polyQ Ataxin-2 to induce motor neuron dysfunction and cell deathRegulation mechanisms and signaling pathways of autophagyAutophagy gone awry in neurodegenerative diseasesDual roles of an Arabidopsis ESCRT component FREE1 in regulating vacuolar protein transport and autophagic degradation.The deubiquitinating enzyme AMSH1 and the ESCRT-III subunit VPS2.1 are required for autophagic degradation in Arabidopsis.HDAC6 controls autophagosome maturation essential for ubiquitin-selective quality-control autophagySafety and efficacy of lithium in combination with riluzole for treatment of amyotrophic lateral sclerosis: a randomised, double-blind, placebo-controlled trial.Deletion of the huntingtin polyglutamine stretch enhances neuronal autophagy and longevity in mice.
P2860
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P2860
Functional multivesicular bodies are required for autophagic clearance of protein aggregates associated with neurodegenerative disease.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Functional multivesicular bodi ...... ith neurodegenerative disease.
@ast
Functional multivesicular bodi ...... ith neurodegenerative disease.
@en
type
label
Functional multivesicular bodi ...... ith neurodegenerative disease.
@ast
Functional multivesicular bodi ...... ith neurodegenerative disease.
@en
prefLabel
Functional multivesicular bodi ...... ith neurodegenerative disease.
@ast
Functional multivesicular bodi ...... ith neurodegenerative disease.
@en
P2093
P2860
P50
P921
P356
P1476
Functional multivesicular bodi ...... ith neurodegenerative disease.
@en
P2093
Adrian Isaacs
Ai Yamamoto
Andreas Brech
Camilla Raiborg
Lene Malerød
Maria Filimonenko
Susanne Stuffers
P2860
P304
P356
10.1083/JCB.200702115
P407
P577
2007-11-01T00:00:00Z