Functional multivesicular bodies are required for autophagic clearance of protein aggregates associated with neurodegenerative disease. - Wikidata - awgldk - TriplyDB

Functional multivesicular bodies are required for autophagic clearance of protein aggregates associated with neurodegenerative disease.

Functional multivesicular bodies are required for autophagic clearance of protein aggregates associated with neurodegenerative disease.

http://www.wikidata.org/entity/Q36119653

about

Dysregulation of the autophagy-endolysosomal system in amyotrophic lateral sclerosis and related motor neuron diseases Alzheimer's disease as homeostatic responses to age-related myelin breakdown Rab GTPase-activating proteins in autophagy: regulation of endocytic and autophagy pathways by direct binding to human ATG8 modifiers The selective macroautophagic degradation of aggregated proteins requires the PI3P-binding protein Alfy Chaperone-like activity of high-mobility group box 1 protein and its role in reducing the formation of polyglutamine aggregates SCAMP5 links endoplasmic reticulum stress to the accumulation of expanded polyglutamine protein aggregates via endocytosis inhibition The FTLD risk factor TMEM106B and MAP6 control dendritic trafficking of lysosomes Vps33b pathogenic mutations preferentially affect VIPAS39/SPE-39-positive endosomes The HOPS complex mediates autophagosome-lysosome fusion through interaction with syntaxin 17 ESCRT-III subunits Snf7-1 and Snf7-2 differentially regulate transmembrane cargos in hESC-derived human neurons The ESCRT complexes Membrane budding and scission by the ESCRT machinery: it's all in the neck Autophagy and pattern recognition receptors in innate immunity The ESCRT machinery: new roles at new holes Ultrastructural studies of ALS mitochondria connect altered function and permeability with defects of mitophagy and mitochondriogenesis Autophagy-Related Deubiquitinating Enzymes Involved in Health and Disease Converging mechanisms in ALS and FTD: disrupted RNA and protein homeostasis Autophagy modulation as a potential therapeutic target for diverse diseases Early etiology of Alzheimer's disease: tipping the balance toward autophagy or endosomal dysfunction?Multiple functions of the SNARE protein Snap29 in autophagy, endocytic, and exocytic trafficking during epithelial formation in Drosophila.Identification of Atypical Peri-Nuclear Multivesicular Bodies in Oxidative and Glycolytic Skeletal Muscle of Aged and Pompe's Disease Mouse Models.The endosomal protein CHARGED MULTIVESICULAR BODY PROTEIN1 regulates the autophagic turnover of plastids in Arabidopsis ESCRT-II controls retinal axon growth by regulating DCC receptor levels and local protein synthesis Structural basis for sorting mechanism of p62 in selective autophagy Parkinson's disease-linked human PARK9/ATP13A2 maintains zinc homeostasis and promotes α-Synuclein externalization via exosomes.Autophagosome dynamics in neurodegeneration at a glance Retromer Ensures the Degradation of Autophagic Cargo by Maintaining Lysosome Function in Drosophila Syntaxin 13, a genetic modifier of mutant CHMP2B in frontotemporal dementia, is required for autophagosome maturation Atg8: an autophagy-related ubiquitin-like protein family Regulation of endocytic sorting by ESCRT-DUB-mediated deubiquitination The ubiquitin-proteasome system in spongiform degenerative disorders Mice deficient in Epg5 exhibit selective neuronal vulnerability to degeneration Loss of C9ORF72 impairs autophagy and synergizes with polyQ Ataxin-2 to induce motor neuron dysfunction and cell death Regulation mechanisms and signaling pathways of autophagy Autophagy gone awry in neurodegenerative diseases Dual roles of an Arabidopsis ESCRT component FREE1 in regulating vacuolar protein transport and autophagic degradation.The deubiquitinating enzyme AMSH1 and the ESCRT-III subunit VPS2.1 are required for autophagic degradation in Arabidopsis.HDAC6 controls autophagosome maturation essential for ubiquitin-selective quality-control autophagy Safety and efficacy of lithium in combination with riluzole for treatment of amyotrophic lateral sclerosis: a randomised, double-blind, placebo-controlled trial.Deletion of the huntingtin polyglutamine stretch enhances neuronal autophagy and longevity in mice.

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P2860

Functional multivesicular bodies are required for autophagic clearance of protein aggregates associated with neurodegenerative disease.

http://www.wikidata.org/entity/Q36119653

description

2007 nî lūn-bûn

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2007年の論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年论文

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2007年论文

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Functional multivesicular bodi ...... ith neurodegenerative disease.

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Functional multivesicular bodi ...... ith neurodegenerative disease.

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Functional multivesicular bodi ...... ith neurodegenerative disease.

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Functional multivesicular bodi ...... ith neurodegenerative disease.

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Journal of Cell Biology

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Functional multivesicular bodi ...... ith neurodegenerative disease.

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P2093

Adrian Isaacs

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Ai Yamamoto

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Andreas Brech

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Camilla Raiborg

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Lene Malerød

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Maria Filimonenko

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Susanne Stuffers

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P2860

Mammalian class E vps proteins recognize ubiquitin and act in the removal of endosomal protein-ubiquitin conjugates

LC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form-II formation

ALS phenotypes with mutations in CHMP2B (charged multivesicular body protein 2B)

The protein network of HIV budding

Alfy, a novel FYVE-domain-containing protein associated with protein granules and autophagic membranes

Mutations in the endosomal ESCRTIII-complex subunit CHMP2B in frontotemporal dementia

p62, a phosphotyrosine-independent ligand of the SH2 domain of p56lck, belongs to a new class of ubiquitin-binding proteins

p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy

EEA1 links PI(3)K function to Rab5 regulation of endosome fusion

The ESCRT-III subunit hVps24 is required for degradation but not silencing of the epidermal growth factor receptor.

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485-500

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10.1083/JCB.200702115

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3

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179

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Harald Stenmark

Elizabeth M. C. Fisher

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2007-11-01T00:00:00Z

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5863017

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17984323

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neurodegeneration

amphisome membrane

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2064794

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