Comparative folate metabolism in humans and malaria parasites (part I): pointers for malaria treatment from cancer chemotherapy.
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Cytokine-associated neutrophil extracellular traps and antinuclear antibodies in Plasmodium falciparum infected children under six years of ageCritical role for tetrahydrobiopterin recycling by dihydrofolate reductase in regulation of endothelial nitric-oxide synthase coupling: relative importance of the de novo biopterin synthesis versus salvage pathwaysEffects of point mutations in Plasmodium falciparum dihydrofolate reductase and dihydropterate synthase genes on clinical outcomes and in vitro susceptibility to sulfadoxine and pyrimethamineTargeting purine and pyrimidine metabolism in human apicomplexan parasitesBiochemical and functional characterization of Plasmodium falciparum GTP cyclohydrolase ITetrahydrobiopterin in cardiovascular health and disease.Safety and benefits of interventions to increase folate status in malaria-endemic areas.Dihydrofolate reductase protects endothelial nitric oxide synthase from uncoupling in tetrahydrobiopterin deficiency.The molecular basis of antifolate resistance in Plasmodium falciparum: looking beyond point mutations.High Dietary Folate in Mice Alters Immune Response and Reduces Survival after Malarial Infection.Comparative folate metabolism in humans and malaria parasites (part II): activities as yet untargeted or specific to Plasmodium.Down-regulation of dihydrofolate reductase inhibits the growth of endothelial EA.hy926 cell through induction of G1 cell cycle arrest via up-regulating p53 and p21(waf1/cip1) expression.Vitamin and cofactor biosynthesis pathways in Plasmodium and other apicomplexan parasites.Direct evidence for the adaptive role of copy number variation on antifolate susceptibility in Plasmodium falciparum.Polymorphism in PfMRP1 (Plasmodium falciparum multidrug resistance protein 1) amino acid 1466 associated with resistance to sulfadoxine-pyrimethamine treatment.Methylene tetrahydrofolate dehydrogenase/cyclohydrolase and the synthesis of 10-CHO-THF are essential in Leishmania major.Environmental influence on the worldwide prevalence of a 776C->G variant in the transcobalamin gene (TCN2).Next-Generation Antimalarial Drugs: Hybrid Molecules as a New Strategy in Drug Design.Synthesis and recycling of tetrahydrobiopterin in endothelial function and vascular disease.Targeting the vitamin biosynthesis pathways for the treatment of malaria.Impact of folate supplementation on the efficacy of sulfadoxine/pyrimethamine in preventing malaria in pregnancy: the potential of 5-methyl-tetrahydrofolate.The role of antioxidants treatment on the pathogenesis of malarial infections: a review.Malaria in the Era of Food Fortification With Folic Acid.Vitamin B6-dependent enzymes in the human malaria parasite Plasmodium falciparum: a druggable target?An atypical orthologue of 6-pyruvoyltetrahydropterin synthase can provide the missing link in the folate biosynthesis pathway of malaria parasites.Plasmodium falciparum: a paradigm for alternative folate biosynthesis in diverse microorganisms?Effect of folate derivatives on the activity of antifolate drugs used against malaria and cancerSynthesis of (+)-7,20-Diisocyanoadociane and Liver-Stage Antiplasmodial Activity of the Isocyanoterpene Class.Modeling metabolism and stage-specific growth of Plasmodium falciparum HB3 during the intraerythrocytic developmental cycle.Design, synthesis and biological evaluation of 6-aryl-1,6-dihydro-1,3,5-triazine-2,4-diamines as antiplasmodial antifolates.Structure of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase-dihydropteroate synthase from Plasmodium vivax sheds light on drug resistance
P2860
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P2860
Comparative folate metabolism in humans and malaria parasites (part I): pointers for malaria treatment from cancer chemotherapy.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
Comparative folate metabolism ...... ment from cancer chemotherapy.
@ast
Comparative folate metabolism ...... ment from cancer chemotherapy.
@en
type
label
Comparative folate metabolism ...... ment from cancer chemotherapy.
@ast
Comparative folate metabolism ...... ment from cancer chemotherapy.
@en
prefLabel
Comparative folate metabolism ...... ment from cancer chemotherapy.
@ast
Comparative folate metabolism ...... ment from cancer chemotherapy.
@en
P2093
P2860
P356
P1476
Comparative folate metabolism ...... ment from cancer chemotherapy.
@en
P2093
Alexis Nzila
John E Hyde
Paul F G Sims
Steve A Ward
P2860
P304
P356
10.1016/J.PT.2005.04.002
P50
P577
2005-06-01T00:00:00Z