Specific developmental disruption of disrupted-in-schizophrenia-1 function results in schizophrenia-related phenotypes in mice. - Wikidata - awgldk - TriplyDB

Specific developmental disruption of disrupted-in-schizophrenia-1 function results in schizophrenia-related phenotypes in mice.

Specific developmental disruption of disrupted-in-schizophrenia-1 function results in schizophrenia-related phenotypes in mice.

http://www.wikidata.org/entity/Q36156959

about

The DISC1 pathway modulates expression of neurodevelopmental, synaptogenic and sensory perception genes Disrupted in schizophrenia 1 regulates neuronal progenitor proliferation via modulation of GSK3beta/beta-catenin signaling Mutant mouse models: genotype-phenotype relationships to negative symptoms in schizophrenia DISC1: a key lead in studying cortical development and associated brain disorders Wnt signaling in neuropsychiatric disorders: ties with adult hippocampal neurogenesis and behavior Gene × Environment Interactions in Schizophrenia: Evidence from Genetic Mouse Models DISC1 at 10: connecting psychiatric genetics and neuroscience Prophylactic valproic acid treatment prevents schizophrenia-related behaviour in Disc1-L100P mutant mice CAMDI, a novel disrupted in schizophrenia 1 (DISC1)-binding protein, is required for radial migration DISC1 regulates new neuron development in the adult brain via modulation of AKT-mTOR signaling through KIAA1212 Dixdc1 is a critical regulator of DISC1 and embryonic cortical development Phenomics: the systematic study of phenotypes on a genome-wide scale Impaired long-term memory retention and working memory in sdy mutant mice with a deletion in Dtnbp1, a susceptibility gene for schizophrenia Noradrenergic Modulation of Cognition in Health and Disease.Genetic and pharmacological evidence for schizophrenia-related Disc1 interaction with GSK-3.Microendophenotypes of psychiatric disorders: phenotypes of psychiatric disorders at the level of molecular dynamics, synapses, neurons, and neural circuits Neurodevelopmental animal models of schizophrenia: role in novel drug discovery and development Schizophrenia and Depression Co-Morbidity: What We have Learned from Animal Models.Repetitive behavior profile and supersensitivity to amphetamine in the C58/J mouse model of autism.Mice with a naturally occurring DISC1 mutation display a broad spectrum of behaviors associated to psychiatric disorders.Modeling psychiatric disorders at the cellular and network levels Pathogenic disruption of DISC1-serine racemase binding elicits schizophrenia-like behavior via D-serine depletion.Turning it upside down: areas of preserved cognitive function in schizophrenia.Deficiency of schnurri-2, an MHC enhancer binding protein, induces mild chronic inflammation in the brain and confers molecular, neuronal, and behavioral phenotypes related to schizophrenia.Reduced expression of the NMDA receptor-interacting protein SynGAP causes behavioral abnormalities that model symptoms of Schizophrenia Is lead exposure in early life an environmental risk factor for Schizophrenia? Neurobiological connections and testable hypotheses.The developing utility of zebrafish models for cognitive enhancers research Animal models of schizophrenia.Abnormal behavior in mice mutant for the Disc1 binding partner, Dixdc1.Glycogen synthase kinase-3 in the etiology and treatment of mood disorders.Review of pathological hallmarks of schizophrenia: comparison of genetic models with patients and nongenetic models Modeling the positive symptoms of schizophrenia in genetically modified mice: pharmacology and methodology aspects Combined effect of neonatal immune activation and mutant DISC1 on phenotypic changes in adulthood.Prepulse inhibition and genetic mouse models of schizophrenia.Animal models of gene-environment interactions in schizophrenia.Nuclear DISC1 regulates CRE-mediated gene transcription and sleep homeostasis in the fruit fly.Transient downregulation of Dab1 protein levels during development leads to behavioral and structural deficits: relevance for psychiatric disorders Effects of background mutations and single nucleotide polymorphisms (SNPs) on the Disc1 L100P behavioral phenotype associated with schizophrenia in mice.Developmental disruptions in neural connectivity in the pathophysiology of schizophrenia.Role of disrupted in schizophrenia 1 (DISC1) in stress-induced prefrontal cognitive dysfunction.

P2860

Q21092132-723B2A15-D709-4FB6-9818-F92316EE73B6 Q24322974-E6B9FB90-98B7-49FD-B0AB-02BCE4344BB8 Q24632939-2BD5B20B-1B66-4DBB-81FE-5639DA877D44 Q26851318-F23A5832-48B8-4A63-AFA6-CEBD6B04E6CF Q27008843-821FBB93-5935-4DC0-B8A2-9699AF4D529C Q28067507-4856FFB8-EDBD-48AB-B82F-F6B8A2880AA7 Q28250914-3BBCE7A6-1C47-45CF-93BE-0A1C9DE1F170 Q28484428-F48991D9-C51E-416C-B687-66F0BB69BEE0 Q28504481-09DE4933-EFAD-4018-9039-AC7A97124830 Q28513802-D37FAC24-03F7-4256-B804-694E3C0AA29E Q28588322-F53EEE73-9689-4CA4-8586-7B4AEF6AA870 Q28750567-DD240EEA-A8C9-4987-B4FE-5B8091ADCE12 Q28756538-FA41A8A2-D0B5-4AD1-9D93-C65FA96B218D Q30354689-C8ADA3C4-E5E7-434B-B1DF-5A25202ED6F9 Q30408186-580B357F-2946-48C1-A897-0C0BF52F2CCD Q30409099-01D4F8F5-F6FB-43D1-BC8C-A1F092ADBB38 Q30414108-3B398C50-061C-45B0-94FA-B391359BFEAE Q30416883-7180A080-1192-4576-918E-516F231FE0B7 Q30419621-5A2DDED7-F90E-4FDA-AC14-777A5FD73531 Q30432973-0D591820-5AA3-49E3-A1E2-AC20A02AA9D8 Q30446669-A41132C8-03AC-42B2-BA32-3E8593113413 Q30447828-9AAE3842-F83B-49D7-9EC2-EDEFAF209A90 Q30450648-43531150-E27F-4B72-9C7A-535D19798C04 Q30453022-025DAC96-1B4E-4EA6-8287-5EE85F8EC0E6 Q30453229-FEFEE63D-B78B-4E58-843E-38A8ACD36F87 Q30454141-BC6D9E6C-80F2-4DC0-B7C3-4DCC0DA83915 Q30457705-9413CEFC-53EC-4308-9509-5F6222350282 Q30462828-D5A03E2C-86CE-4800-A94B-2268EDF0D663 Q30468809-BFDBCA96-280D-465A-A94E-E53871D0C4E2 Q30474415-69F7948E-FB56-4439-8DD4-C28881FB1FC7 Q30476810-9F2423C0-FEC4-4726-8D7A-6041F4965328 Q30476813-A94DE91F-9306-40FF-B0D3-8BFAC64050CD Q30477667-713D6E40-C688-4C6E-8738-C4E6CF2617D2 Q30478270-F673BE34-87A1-4076-B34F-1E1B1072159C Q30478272-E2BED746-F611-4D63-912C-B8FDA8BFDC1C Q30489568-08658A69-0C1D-4F5E-A099-BCFC9951D0AB Q30565470-5867DDEE-8C8F-40DB-9C76-1B2CF2CCA919 Q30615734-B6E5BEFA-A132-4169-9C2A-357EA8929A0D Q33374181-92D1002F-9E83-4740-AFB9-8FA6F5899310 Q33647493-C20BE5B8-7A6F-48F2-9611-4E6FD0C87944

P2860

Specific developmental disruption of disrupted-in-schizophrenia-1 function results in schizophrenia-related phenotypes in mice.

http://www.wikidata.org/entity/Q36156959

description

2007 nî lūn-bûn

@nan

2007年の論文

@ja

2007年論文

@yue

2007年論文

@zh-hant

2007年論文

@zh-hk

2007年論文

@zh-mo

2007年論文

@zh-tw

2007年论文

@wuu

2007年论文

@zh

2007年论文

@zh-cn

name

Specific developmental disrupt ...... ia-related phenotypes in mice.

@ast

Specific developmental disrupt ...... ia-related phenotypes in mice.

@en

type

label

Specific developmental disrupt ...... ia-related phenotypes in mice.

@ast

Specific developmental disrupt ...... ia-related phenotypes in mice.

@en

prefLabel

Specific developmental disrupt ...... ia-related phenotypes in mice.

@ast

Specific developmental disrupt ...... ia-related phenotypes in mice.

@en

P1433

Q36156959-08B8DAF7-3795-45B0-A7F9-B1D7EE691FCA

P1476

Q36156959-F2D0375D-A811-4D0C-BA10-9AB9605BAAEE

P2093

Q36156959-14468D37-3F7E-4E7D-A97D-755026CE2532

Q36156959-472269C3-C6FF-42B4-B6A7-5ED0DDB06589

Q36156959-6687164A-CAE0-4FEB-AA5E-AB920F215EA3

Q36156959-6DB7C4FE-ACB3-4A54-AA85-F67B4213156B

Q36156959-913CA428-7B81-41AF-8B3A-215E4874F881

Q36156959-CBBBC72B-D056-4B35-AE7F-61BF48B4340F

Q36156959-F99F1918-A5C9-47F8-8851-896E9470F26D

P2860

Q36156959-01297431-7D78-40E3-ADD6-B161DDC03794

Q36156959-02B343F8-4468-4F79-84C2-5D51D6FD1842

Q36156959-07C71BEC-7C10-4352-A16B-93791784DCBF

Q36156959-17C2D4C8-B1DE-4C33-B54C-E580418FBE29

Q36156959-1E40822B-7849-4244-ADCF-22FE26C4FBA0

Q36156959-289101E3-E4ED-43AF-BD2F-5838130917BC

Q36156959-3678FF50-5B08-40C9-A29E-BCA33EB454CD

Q36156959-4216E7BD-7FCD-4453-AC15-6EF348756DED

Q36156959-4484E283-07A9-497D-B7EE-14A73284B066

Q36156959-4B30F7B0-0B4A-4B83-B740-10CE3CA9AB11

P304

Q36156959-AA5621ED-841D-4146-A0C9-D556C2C5648E

P31

Q36156959-8C6F828F-111C-44C2-8AAA-3099C95B7C50

P356

Q36156959-DFFDD99C-6322-4201-B486-D73A10BD3A44

P407

Q36156959-FF43DA97-5015-4FA7-ABDD-7CAF5CC66F73

P433

Q36156959-F2A74DB8-16AD-49A0-87B3-C4A1C5A1813E

P478

Q36156959-AD992834-EA2A-4F4A-98EF-BE02F3C1F12C

P50

Q36156959-333F3D16-CFEF-4F39-96D6-5AC7B08DF7AC

Q36156959-6893B125-E559-4E30-B168-77032B8E9FDE

Q36156959-84D56C1B-1407-450F-9E71-3655190EC63D

Q36156959-B684C3FF-BF22-4548-A63F-AF4F72D9172B

Q36156959-BD04F630-C0A0-49EE-BA91-E3F4BB6867D1

Q36156959-CCF48A00-125D-450B-9A46-AB32F65CE469

Q36156959-FF760B39-DCAF-40F9-9D26-C63D1476CE62

P577

Q36156959-327A3C0B-65BE-4FF8-8BE4-2021B19F6771

P5875

Q36156959-621E8AC6-D91C-4811-AF61-EF606B6DA814

P698

Q36156959-62EA9787-39D7-45BE-8BD7-D09029C4D25B

P921

Q36156959-4709C4FF-225B-4322-A438-AF6F99EE1F79

P932

Q36156959-39EA826A-7719-4FF5-B7DE-8F6B4128A6A0

P356

PNAS.0706900104

P1433

Proceedings of the National Academy of Sciences of the United States of America

P1476

Specific developmental disrupt ...... ia-related phenotypes in mice.

@en

P2093

Dan Ehninger

http://www.w3.org/2001/XMLSchema#string

Joshua T Trachtenberg

http://www.w3.org/2001/XMLSchema#string

Matti O Huttunen

http://www.w3.org/2001/XMLSchema#string

Robert A M Brown

http://www.w3.org/2001/XMLSchema#string

Weidong Li

http://www.w3.org/2001/XMLSchema#string

Xiaoli Tian

http://www.w3.org/2001/XMLSchema#string

Yu Zhou

http://www.w3.org/2001/XMLSchema#string

P2860

DISC1 (Disrupted-In-Schizophrenia 1) is a centrosome-associated protein that interacts with MAP1A, MIPT3, ATF4/5 and NUDEL: regulation and loss of interaction with mutation

DISC1-NDEL1/NUDEL protein interaction, an essential component for neurite outgrowth, is modulated by genetic variations of DISC1

Disrupted-in-Schizophrenia-1 (DISC-1): mutant truncation prevents binding to NudE-like (NUDEL) and inhibits neurite outgrowth

Disruption of two novel genes by a translocation co-segregating with schizophrenia

Yeast two-hybrid screens implicate DISC1 in brain development and function

The endophenotype concept in psychiatry: etymology and strategic intentions

Haplotype transmission analysis provides evidence of association for DISC1 to schizophrenia and suggests sex-dependent effects

Disrupted in Schizophrenia 1 and Nudel form a neurodevelopmentally regulated protein complex: implications for schizophrenia and other major neurological disorders

The genetics and biology of DISC1--an emerging role in psychosis and cognition

Depression: a new animal model sensitive to antidepressant treatments

P304

18280-18285

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1073/PNAS.0706900104

http://www.w3.org/2001/XMLSchema#string

P407

P433

46

http://www.w3.org/2001/XMLSchema#string

P478

104

http://www.w3.org/2001/XMLSchema#string

P50

Alcino J. Silva

Leena Peltonen-Palotie

J. David Jentsch

Jouko Lönnqvist

P577

2007-11-02T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

5862729

http://www.w3.org/2001/XMLSchema#string

P698

17984054

http://www.w3.org/2001/XMLSchema#string

P921

P932

2084334

http://www.w3.org/2001/XMLSchema#string