Multiple but dissectible functions of FEN-1 nucleases in nucleic acid processing, genome stability and diseases. - Wikidata - awgldk - TriplyDB

Multiple but dissectible functions of FEN-1 nucleases in nucleic acid processing, genome stability and diseases.

Multiple but dissectible functions of FEN-1 nucleases in nucleic acid processing, genome stability and diseases.

http://www.wikidata.org/entity/Q36162105

about

Human RECQL5 participates in the removal of endogenous DNA damage Okazaki fragment maturation: nucleases take centre stage The 3'-flap pocket of human flap endonuclease 1 is critical for substrate binding and catalysis Association between FEN1 Polymorphisms -69G>A and 4150G>T with Susceptibility in Human Disease: A Meta-Analysis Identification and Characterization of the V(D)J Recombination Activating Gene 1 in Long-Term Memory of Context Fear Conditioning.Crystal structure of bacteriophage T4 5' nuclease in complex with a branched DNA reveals how flap endonuclease-1 family nucleases bind their substrates Roles of ChlR1 DNA helicase in replication recovery from DNA damage Overexpression and hypomethylation of flap endonuclease 1 gene in breast and other cancers Wuho Is a New Member in Maintaining Genome Stability through its Interaction with Flap Endonuclease 1 Identification of flap structure-specific endonuclease 1 as a factor involved in long-term memory formation of aversive learning Flap endonuclease-1 rs174538 G>A polymorphisms are associated with the risk of esophageal cancer in a Chinese population FEN1 promotes tumor progression and confers cisplatin resistance in non-small-cell lung cancer.A model for transition of 5'-nuclease domain of DNA polymerase I from inert to active modes Human RECQL5beta stimulates flap endonuclease 1 Comprehensive classification of the PIN domain-like superfamily The human Suv3 helicase interacts with replication protein A and flap endonuclease 1 in the nucleus Mechanism of Holliday junction resolution by the human GEN1 protein FEN1 -69G>A and 4150G>T polymorphisms and cancer risk in Chinese population.Methylation of FEN1 suppresses nearby phosphorylation and facilitates PCNA binding Kinetics of endogenous mouse FEN1 in base excision repair.The DNA-protein interaction modes of FEN-1 with gap substrates and their implication in preventing duplication mutations.Complementary non-radioactive assays for investigation of human flap endonuclease 1 activity.Functional regulation of FEN1 nuclease and its link to cancer A cryptic targeting signal creates a mitochondrial FEN1 isoform with tailed R-Loop binding properties.Structure and specificity of FEN-1 from Methanopyrus kandleri Roles of the Werner syndrome RecQ helicase in DNA replication.Complex minisatellite rearrangements generated in the total or partial absence of Rad27/hFEN1 activity occur in a single generation and are Rad51 and Rad52 dependent.YY1 suppresses FEN1 over-expression and drug resistance in breast cancer Apoptosis induced by persistent single-strand breaks in mitochondrial genome: critical role of EXOG (5'-EXO/endonuclease) in their repair Kinase consensus sequences: a breeding ground for crosstalk.RECQ1 interacts with FEN-1 and promotes binding of FEN-1 to telomeric chromatin.High risk of benzo[α]pyrene-induced lung cancer in E160D FEN1 mutant mice The trans-autostimulatory activity of Rad27 suppresses dna2 defects in Okazaki fragment processing.Disruption of the FEN-1/PCNA interaction results in DNA replication defects, pulmonary hypoplasia, pancytopenia, and newborn lethality in mice.Adenomatous polyposis coli interacts with flap endonuclease 1 to block its nuclear entry and function Flap endonuclease 1 polymorphisms (rs174538 and rs4246215) contribute to an increased cancer risk: Evidence from a meta-analysis.Genomic and protein expression analysis reveals flap endonuclease 1 (FEN1) as a key biomarker in breast and ovarian cancer Small molecule inhibitors uncover synthetic genetic interactions of human flap endonuclease 1 (FEN1) with DNA damage response genes.Flap endonuclease 1 contributes to telomere stability Nucleolar localization and dynamic roles of flap endonuclease 1 in ribosomal DNA replication and damage repair.

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Multiple but dissectible functions of FEN-1 nucleases in nucleic acid processing, genome stability and diseases.

http://www.wikidata.org/entity/Q36162105

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Multiple but dissectible funct ...... genome stability and diseases.

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Multiple but dissectible funct ...... genome stability and diseases.

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Multiple but dissectible funct ...... genome stability and diseases

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Binghui Shen

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Junzhuan Qiu

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Li Zheng

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Purnima Singh

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Ren Liu

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Steve Alas

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P2860

Structural and functional conservation of the human homolog of the Schizosaccharomyces pombe rad2 gene, which is required for chromosome segregation and recovery from DNA damage

A yeast replicative helicase, Dna2 helicase, interacts with yeast FEN-1 nuclease in carrying out its essential function

Destabilization of yeast micro- and minisatellite DNA sequences by mutations affecting a nuclease involved in Okazaki fragment processing (rad27) and DNA polymerase delta (pol3-t).

A novel role in DNA metabolism for the binding of Fen1/Rad27 to PCNA and implications for genetic risk.

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717-729

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10.1002/BIES.20255

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L. David Finger

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