Methylation of FEN1 suppresses nearby phosphorylation and facilitates PCNA binding
about
Okazaki fragment maturation: nucleases take centre stageBase Excision Repair, a Pathway Regulated by Posttranslational ModificationsThe PRMT5 arginine methyltransferase: many roles in development, cancer and beyondArginine methylation of G3BP1 in response to Wnt3a regulates β-catenin mRNAInterplay between arginine methylation and ubiquitylation regulates KLF4-mediated genome stability and carcinogenesis.Interacting partners of FEN1 and its role in the development of anticancer therapeutics.FEN1 promotes tumor progression and confers cisplatin resistance in non-small-cell lung cancer.Tumor necrosis factor (TNF)-α induction of CXCL10 in endothelial cells requires protein arginine methyltransferase 5 (PRMT5)-mediated nuclear factor (NF)-κB p65 methylation.Arginine methylation of hnRNPK negatively modulates apoptosis upon DNA damage through local regulation of phosphorylation.Structural basis for phosphorylation and lysine acetylation cross-talk in a kinase motif associated with myocardial ischemia and cardioprotectionKinetics of endogenous mouse FEN1 in base excision repair.Functional regulation of FEN1 nuclease and its link to cancerEukaryotic lagging strand DNA replication employs a multi-pathway mechanism that protects genome integrityFen1 mutations that specifically disrupt its interaction with PCNA cause aneuploidy-associated cancerKinase consensus sequences: a breeding ground for crosstalk.Flap endonucleases pass 5'-flaps through a flexible arch using a disorder-thread-order mechanism to confer specificity for free 5'-ends.Arginine methyltransferase PRMT5 is essential for sustaining normal adult hematopoiesis.Polyploid cells rewire DNA damage response networks to overcome replication stress-induced barriers for tumour progression.Sequential posttranslational modifications program FEN1 degradation during cell-cycle progressionFlap endonuclease 1.The wonders of flap endonucleases: structure, function, mechanism and regulation.Lysine Acetylation and Succinylation in HeLa Cells and their Essential Roles in Response to UV-induced Stress.PRMT5-Dependent Methylation of the TIP60 Coactivator RUVBL1 Is a Key Regulator of Homologous Recombination.Nuclear PRMT5, cyclin D1 and IL-6 are associated with poor outcome in oropharyngeal squamous cell carcinoma patients and is inversely associated with p16-status.The methylproteome and the intracellular methylation network.BERing the burden of damage: Pathway crosstalk and posttranslational modification of base excision repair proteins regulate DNA damage management.Identification of the PRMT1v1 and PRMT1v2 specific interactomes by quantitative mass spectrometry in breast cancer cells.Protein arginine methylation/demethylation and cancer.The story of protein arginine methylation: characterization, regulation, and function.Protein arginine methyltransferase 5 is a potential oncoprotein that upregulates G1 cyclins/cyclin-dependent kinases and the phosphoinositide 3-kinase/AKT signaling cascade.Comprehensive identification of arginine methylation in primary T cells reveals regulatory roles in cell signalling.Arginine methylation of hnRNPUL1 regulates interaction with NBS1 and recruitment to sites of DNA damage.Coordination of multiple enzyme activities by a single PCNA in archaeal Okazaki fragment maturation.Site-specific and regiospecific installation of methylarginine analogues into recombinant histones and insights into effector protein bindingLysine methylation of FEN1 by SET7 is essential for its cellular response to replicative stress.Role of FEN1 S187 phosphorylation in counteracting oxygen-induced stress and regulating postnatal heart development.PRMT5-mediated arginine methylation of TDP1 for the repair of topoisomerase I covalent complexes.Protein arginine methylation: an emerging regulator of the cell cycle.JMJD1B Demethylates H4R3me2s and H3K9me2 to Facilitate Gene Expression for Development of Hematopoietic Stem and Progenitor Cells.rs4246215 is targeted by hsa-miR1236 to regulate FEN1 expression but is not associated with Fuchs' endothelial corneal dystrophy
P2860
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P2860
Methylation of FEN1 suppresses nearby phosphorylation and facilitates PCNA binding
description
2010 nî lūn-bûn
@nan
2010 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Methylation of FEN1 suppresses nearby phosphorylation and facilitates PCNA binding
@ast
Methylation of FEN1 suppresses nearby phosphorylation and facilitates PCNA binding
@en
Methylation of FEN1 suppresses nearby phosphorylation and facilitates PCNA binding
@nl
type
label
Methylation of FEN1 suppresses nearby phosphorylation and facilitates PCNA binding
@ast
Methylation of FEN1 suppresses nearby phosphorylation and facilitates PCNA binding
@en
Methylation of FEN1 suppresses nearby phosphorylation and facilitates PCNA binding
@nl
prefLabel
Methylation of FEN1 suppresses nearby phosphorylation and facilitates PCNA binding
@ast
Methylation of FEN1 suppresses nearby phosphorylation and facilitates PCNA binding
@en
Methylation of FEN1 suppresses nearby phosphorylation and facilitates PCNA binding
@nl
P2093
P2860
P356
P1476
Methylation of FEN1 suppresses nearby phosphorylation and facilitates PCNA binding
@en
P2093
Binghui Shen
Huifang Dai
Mary Rose Pascua
Qin M Chen
Zhigang Guo
P2860
P2888
P304
P356
10.1038/NCHEMBIO.422
P577
2010-08-22T00:00:00Z