Depletion of intracellular Ca2+ stores, phosphorylation of eIF2alpha, and sustained inhibition of translation initiation mediate the anticancer effects of clotrimazole
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Antisense-mediated loss of calcium homoeostasis endoplasmic reticulum protein (CHERP; ERPROT213-21) impairs Ca2+ mobilization, nuclear factor of activated T-cells (NFAT) activation and cell proliferation in Jurkat T-lymphocytesEvidence of p53-dependent cross-talk between ribosome biogenesis and the cell cycle: effects of nucleolar protein Bop1 on G(1)/S transitionNitric oxide-induced cytostasis and cell cycle arrest of a human breast cancer cell line (MDA-MB-231): potential role of cyclin D1Activation of tumor necrosis factor receptor 1 in airway smooth muscle: a potential pathway that modulates bronchial hyper-responsiveness in asthma?Antiapoptotic and oncogenic potentials of hepatitis C virus are linked to interferon resistance by viral repression of the PKR protein kinasePERK mediates cell-cycle exit during the mammalian unfolded protein responseAndrogen signaling promotes translation of TMEFF2 in prostate cancer cells via phosphorylation of the α subunit of the translation initiation factor 217alpha-Hydroxylase/17,20 lyase inhibitor VN/124-1 inhibits growth of androgen-independent prostate cancer cells via induction of the endoplasmic reticulum stress response.The in vitro and in vivo antitumor effects of clotrimazole on oral squamous cell carcinoma.Signal transduction pathways that regulate eukaryotic protein synthesis.Modulation of molecular mechanisms involved in protein synthesis machinery as a new tool for the control of cell proliferation.Production of infectious human cytomegalovirus virions is inhibited by drugs that disrupt calcium homeostasis in the endoplasmic reticulumDual activators of protein kinase R (PKR) and protein kinase R-like kinase PERK identify common and divergent catalytic targets.PPAR-gamma receptor ligands: novel therapy for pituitary adenomas.Explorations of substituted urea functionality for the discovery of new activators of the heme-regulated inhibitor kinaseMammalian unfolded protein response inhibits cyclin D1 translation and cell-cycle progression.Depletion of eIF2·GTP·Met-tRNAi translation initiation complex up-regulates BRCA1 expression in vitro and in vivo.Translational control of SCL-isoform expression in hematopoietic lineage choice.Tumor suppression by small molecule inhibitors of translation initiation.Chemical genetics identify eIF2α kinase heme-regulated inhibitor as an anticancer targetRepression of PKR mediates palmitate-induced apoptosis in HepG2 cells through regulation of Bcl-2.Potent antimalarial activity of clotrimazole in in vitro cultures of Plasmodium falciparum.Small-Molecule targeting of translation initiation for cancer therapy.Targeting translation: eIF4E as an emerging anticancer drug target.Development of 1-((1,4-trans)-4-Aryloxycyclohexyl)-3-arylurea Activators of Heme-Regulated Inhibitor as Selective Activators of the Eukaryotic Initiation Factor 2 Alpha (eIF2α) Phosphorylation Arm of the Integrated Endoplasmic Reticulum Stress RespoClotrimazole induces a late G1 cell cycle arrest and sensitizes glioblastoma cells to radiation in vitro.In vitro inhibition of translation initiation by N,N'-diarylureas--potential anti-cancer agents.Embryonic lethal abnormal vision-like HuR-dependent mRNA stability regulates post-transcriptional expression of cyclin-dependent kinase inhibitor p27Kip1.Citrate shows specific, dose-dependent lympholytic activity in neoplastic cell lines.Increased calcium influx and ribosomal content correlate with resistance to endoplasmic reticulum stress-induced cell death in mutant leukemia cell lines.Biochemical correlates of thiazolidinedione-induced adipocyte differentiation by high-resolution magic angle spinning NMR spectroscopy.Effect of clotrimazole on the pump cycle of the Na,K-ATPase.Functional KCa3.1 K+ channels are required for human lung mast cell migrationRole of the K(Ca)3.1 K+ channel in auricular lymph node CD4+ T-lymphocyte function of the delayed-type hypersensitivity model.Clotrimazole binds to heme and enhances heme-dependent hemolysis: proposed antimalarial mechanism of clotrimazole.Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells.Effects of clotrimazole on transport mediated by multidrug resistance associated protein 1 (MRP1) in human erythrocytes and tumour cells.Mutations in the S4-H2 loop of eIF4E which increase the affinity for m7GTP.Differential effects of antiangiogenic compounds in neovascularization, leukocyte recruitment, VEGF production, and tumor growth in mice.Clotrimazole inhibits hemoperoxidase of Plasmodium falciparum and induces oxidative stress. Proposed antimalarial mechanism of clotrimazole.
P2860
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P2860
Depletion of intracellular Ca2+ stores, phosphorylation of eIF2alpha, and sustained inhibition of translation initiation mediate the anticancer effects of clotrimazole
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
1998年论文
@zh
1998年论文
@zh-cn
name
Depletion of intracellular Ca2 ...... cancer effects of clotrimazole
@ast
Depletion of intracellular Ca2 ...... cancer effects of clotrimazole
@en
type
label
Depletion of intracellular Ca2 ...... cancer effects of clotrimazole
@ast
Depletion of intracellular Ca2 ...... cancer effects of clotrimazole
@en
prefLabel
Depletion of intracellular Ca2 ...... cancer effects of clotrimazole
@ast
Depletion of intracellular Ca2 ...... cancer effects of clotrimazole
@en
P2093
P2860
P356
P1476
Depletion of intracellular Ca2 ...... cancer effects of clotrimazole
@en
P2093
J A Acosta
J A Halperin
J M Savage
S S Palakurthi
P2860
P304
P356
10.1073/PNAS.95.14.8280
P407
P577
1998-07-01T00:00:00Z