EF24 induces G2/M arrest and apoptosis in cisplatin-resistant human ovarian cancer cells by increasing PTEN expression - Wikidata - awgldk - TriplyDB

EF24 induces G2/M arrest and apoptosis in cisplatin-resistant human ovarian cancer cells by increasing PTEN expression

EF24 induces G2/M arrest and apoptosis in cisplatin-resistant human ovarian cancer cells by increasing PTEN expression

http://www.wikidata.org/entity/Q36175652

about

Identifying microRNA/mRNA dysregulations in ovarian cancer High mesothelin correlates with chemoresistance and poor survival in epithelial ovarian carcinoma In vivo and in vitro suppression of hepatocellular carcinoma by EF24, a curcumin analog Mitochondrial-targeted curcuminoids: a strategy to enhance bioavailability and anticancer efficacy of curcumin CLEFMA-an anti-proliferative curcuminoid from structure-activity relationship studies on 3,5-bis(benzylidene)-4-piperidones.Safe and targeted anticancer efficacy of a novel class of antioxidant-conjugated difluorodiarylidenyl piperidones: differential cytotoxicity in healthy and cancer cells Anticancer efficacy of a difluorodiarylidenyl piperidone (HO-3867) in human ovarian cancer cells and tumor xenografts.Trimetazidine, administered at the onset of reperfusion, ameliorates myocardial dysfunction and injury by activation of p38 mitogen-activated protein kinase and Akt signaling.Hypoxia induces chemoresistance in ovarian cancer cells by activation of signal transducer and activator of transcription 3.Diphenyl difluoroketone: a potent chemotherapy candidate for human hepatocellular carcinoma HO-3867, a synthetic compound, inhibits the migration and invasion of ovarian carcinoma cells through downregulation of fatty acid synthase and focal adhesion kinase.RAB8 enhances TMEM205-mediated cisplatin resistance.Autophagy and apoptosis in hepatocellular carcinoma induced by EF25-(GSH)2: a novel curcumin analog.Connection between Tumor Suppressor BRCA1 and PTEN in Damaged DNA Repair Cellular uptake, retention and bioabsorption of HO-3867, a fluorinated curcumin analog with potential antitumor properties.Targeting constitutively-activated STAT3 in hypoxic ovarian cancer, using a novel STAT3 inhibitor Aberrantly activated pSTAT3-Ser727 in human endometrial cancer is suppressed by HO-3867, a novel STAT3 inhibitor.HO-3867, a safe STAT3 inhibitor, is selectively cytotoxic to ovarian cancer.The curcuminoid CLEFMA selectively induces cell death in H441 lung adenocarcinoma cells via oxidative stress.Liposome-encapsulated EF24-HPβCD inclusion complex: a preformulation study and biodistribution in a rat model.Chemoresistance is associated with Beclin-1 and PTEN expression in epithelial ovarian cancers.Mouse pharmacokinetics and metabolism of the curcumin analog, 4-piperidinone,3,5-bis[(2-fluorophenyl)methylene]-acetate(3E,5E) (EF-24; NSC 716993).Recombinant viral protein promotes apoptosis and suppresses invasion of ovarian adenocarcinoma cells by targeting α5β1 integrin to down-regulate Akt and MMP-2 Anticancer activity of an imageable curcuminoid 1-[2-aminoethyl-(6-hydrazinopyridine-3-carbamidyl)-3,5-bis-(2-fluorobenzylidene)-4-piperidone (EFAH)Inhibition of the NF-κB signaling pathway by the curcumin analog, 3,5-Bis(2-pyridinylmethylidene)-4-piperidone (EF31): anti-inflammatory and anti-cancer properties.Synergistic effect of allyl isothiocyanate (AITC) on cisplatin efficacy in vitro and in vivo.Expression of NF-κB and PTEN in primary epithelial ovarian carcinoma and the correlation with chemoresistance.RY-2f, an isoflavone analog, overcomes cisplatin resistance to inhibit ovarian tumorigenesis via targeting the PI3K/AKT/mTOR signaling pathway.Safe and targeted anticancer therapy for ovarian cancer using a novel class of curcumin analogs Activation of the p38 pathway by a novel monoketone curcumin analog, EF24, suggests a potential combination strategy Synthetic curcumin analog EF31 inhibits the growth of head and neck squamous cell carcinoma xenografts Cardioprotection by HO-4038, a novel verapamil derivative, targeted against ischemia and reperfusion-mediated acute myocardial infarction Inhibition of IkappaB kinase-nuclear factor-kappaB signaling pathway by 3,5-bis(2-flurobenzylidene)piperidin-4-one (EF24), a novel monoketone analog of curcumin.EF24 induces ROS-mediated apoptosis via targeting thioredoxin reductase 1 in gastric cancer cells.EF24 inhibits tumor growth and metastasis via suppressing NF-kappaB dependent pathways in human cholangiocarcinoma.Synergistic antitumor activity of rapamycin and EF24 via increasing ROS for the treatment of gastric cancer.PTEN in DNA damage repair.A liposomal formulation of the synthetic curcumin analog EF24 (Lipo-EF24) inhibits pancreatic cancer progression: towards future combination therapies.PDCD5 transfection increases cisplatin sensitivity and decreases invasion in hepatic cancer cells.EF24 and RAD001 potentiates the anticancer effect of platinum-based agents in human malignant pleural mesothelioma (MSTO-211H) cells and protects nonmalignant mesothelial (MET-5A) cells.

P2860

Q21199589-BC578829-5CD9-4E85-86F8-04D094126F4D Q24658024-83142C25-353A-4C9A-BAD1-6B01E0F1D950 Q28484672-4741FFD2-04DE-4A5C-8BDB-7195F3E09A68 Q28540774-775D64D3-1E7D-4A00-BC01-246E9BE7B3DE Q30496742-F5368DF6-857D-4566-833C-5358607EEEB6 Q33762105-0046632B-F85C-4BD6-A074-7C1E7C66B753 Q33843535-54487EB1-2C5B-464E-8AB5-7DA8E94AA831 Q33861991-AFDC72E0-50D7-4B4F-B2E7-B42A8F3E5180 Q33945427-FEDC0BD3-2A8D-4ACE-935C-469139780253 Q34013776-2320E542-94BA-4DDA-8575-A7C593FAA27B Q34139276-2ADB97E9-4ABF-4020-A0BB-EAD2C007474E Q34221132-1BC20322-F283-4A6B-8CAA-5CADBD1B411C Q34277096-1B197675-53E8-43D1-A94F-5DA43130D751 Q34481443-10AC6E15-2336-4241-A334-C0DE107CB4DD Q34616583-D96394A2-F956-4759-B7AF-2567084487EA Q34781159-1D8A90F2-B4F6-4F0B-A163-BB0B76427D70 Q34819689-3D7C4270-DCE8-4820-9D3B-9D1189CEA909 Q34855872-FE420F13-1BD8-4027-9623-CA44BF7CCBD2 Q35032472-33EDFAB3-C459-4806-AD91-98852EF9E6E5 Q35110669-22A9FEB3-F904-45E9-BA3E-63AE0F39153D Q35167494-5FE5E6A8-C588-4B55-A9B0-52F737DC27E4 Q35360274-0751D6C2-113B-4C6B-9B63-50671FAEC710 Q35708197-BB3FD9E1-A957-4CDC-91AE-CAE02BA33D6F Q35737667-57262595-5D0B-4067-8B54-2B4E98B8B48A Q36025944-87427B7D-25C1-4931-A142-F64EF73274D8 Q36057163-0E974CA6-A419-41C4-9988-D4F5DB12803D Q36261565-8048F6EA-B1E1-467B-BA2C-5BC794066490 Q36413165-63AF6F29-961E-4D8F-87BC-863801F31EEC Q36880907-DDB341EA-BE8E-4823-AC1F-D30A36D12302 Q36949142-A875C1F8-D0A6-45BA-B2CC-B4DFD6B501FC Q37073686-B9C2A72F-CF6D-495C-8BAC-3862ADDA79EB Q37088307-481C9564-0071-4590-BD7C-CC625F4AEDEE Q37089549-C1DAC809-C312-4C5E-9739-6B68282113AB Q37109676-81D5B2A3-A977-4287-802D-E1E50EA8C0FE Q37215717-5BBFE3EC-78A0-443F-8788-FB221EA2F36C Q37306916-DD44835D-3B72-4B5F-A712-24062562D1B4 Q37977769-A75B3E90-301F-4137-922C-911DCC7E20AA Q38758760-EC544DA4-2F8C-4FD2-B6B5-56276945EBE9 Q38936648-473141C5-B4E6-4130-AA90-5AA0987DD661 Q38974983-D2A486B2-D326-45B6-B87C-49BE1E2406D3

P2860

EF24 induces G2/M arrest and apoptosis in cisplatin-resistant human ovarian cancer cells by increasing PTEN expression

http://www.wikidata.org/entity/Q36175652

description

2007 nî lūn-bûn

@nan

2007年の論文

@ja

2007年論文

@yue

2007年論文

@zh-hant

2007年論文

@zh-hk

2007年論文

@zh-mo

2007年論文

@zh-tw

2007年论文

@wuu

2007年论文

@zh

2007年论文

@zh-cn

name

EF24 induces G2/M arrest and a ...... by increasing PTEN expression

@ast

EF24 induces G2/M arrest and a ...... by increasing PTEN expression

@en

type

label

EF24 induces G2/M arrest and a ...... by increasing PTEN expression

@ast

EF24 induces G2/M arrest and a ...... by increasing PTEN expression

@en

prefLabel

EF24 induces G2/M arrest and a ...... by increasing PTEN expression

@ast

EF24 induces G2/M arrest and a ...... by increasing PTEN expression

@en

P1433

Q36175652-960B1B48-4340-4AE6-B42A-DC293CFFED45

P1476

Q36175652-F93F2372-C5E6-48E7-B1EA-518361D8E033

P2093

Q36175652-1624723A-C859-4046-9DF1-2ECD8B85B36A

Q36175652-1D5C5C74-EF3C-4428-BDE1-71C8C6B4EA2D

Q36175652-41931550-1876-419A-9800-A25AC008AB40

Q36175652-721FD63B-822B-4EBA-8C18-89768001B77D

Q36175652-74B0E410-1566-41B8-9BFB-24BEDE7A87FD

Q36175652-8A60D5B2-8552-4B67-BE0C-A36892E363DA

Q36175652-9C4B0017-1B3E-4FE6-AAF7-07C0C72DBDC8

Q36175652-B882A466-2BF5-4EF9-8E92-79BDD20DEFB2

P2860

Q36175652-019CD62C-C2C4-4320-B19A-4862150BF121

Q36175652-0378D17F-61EC-4186-8373-6E75F8E42ED6

Q36175652-091CB5D5-828C-4A33-A52F-493B52A256A6

Q36175652-0F1097CE-1F4B-42B8-ADB4-70A302D8CD5A

Q36175652-11920BFC-4B5D-4706-B296-98B1F4899DAA

Q36175652-11B47AB9-5DDA-40B0-9BE5-31A80C0E1150

Q36175652-19A67332-55D0-49BC-84BF-877DF19C69C7

Q36175652-1D1EC853-BD39-46F3-9166-C2DCBC5E0CCA

Q36175652-2AF561BF-6BC9-411E-9EE7-9F606408E891

Q36175652-2DEAE5F6-9191-4F29-B1BC-679110B34B4C

P304

Q36175652-07B3FAAC-0715-4D03-BB82-BC96B719777B

P31

Q36175652-BBA2D166-5C85-47F1-8D4E-DD59E5FB95E0

P356

Q36175652-3A1523CE-0F04-457E-B82F-DC3C60BBEF38

P407

Q36175652-16411EFB-A7AF-4ACB-9A12-848333985205

P433

Q36175652-A1D5DBC2-5471-4DBB-AFFB-301838A7EE89

P478

Q36175652-83E8A866-19C3-4966-944B-4DED7C132F2E

P577

Q36175652-3508E04B-D521-467B-9E2A-E5B243EBCBFF

P698

Q36175652-EAE115FA-D109-4E3D-8416-856E90A6AA6F

P921

Q36175652-51536E76-C6B4-4824-BA35-12BD146A8E63

P932

Q36175652-FC659CB3-D5DA-44A9-9187-0B2DD1AC1441

P356

P1433

Journal of Biological Chemistry

P1476

EF24 induces G2/M arrest and a ...... by increasing PTEN expression

@en

P2093

Anna Bratasz

http://www.w3.org/2001/XMLSchema#string

Kalman Hideg

http://www.w3.org/2001/XMLSchema#string

Karuppaiyah Selvendiran

http://www.w3.org/2001/XMLSchema#string

Liyue Tong

http://www.w3.org/2001/XMLSchema#string

Nancy J Trigg

http://www.w3.org/2001/XMLSchema#string

Periannan Kuppusamy

http://www.w3.org/2001/XMLSchema#string

Shilpa Vishwanath

http://www.w3.org/2001/XMLSchema#string

Vijay K Kutala

http://www.w3.org/2001/XMLSchema#string

P2860

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

The tumor suppressor PTEN is phosphorylated by the protein kinase CK2 at its C terminus. Implications for PTEN stability to proteasome-mediated degradation

The role of the ubiquitination-proteasome pathway in breast cancer: applying drugs that affect the ubiquitin-proteasome pathway to the therapy of breast cancer

Activation of PI3K/Akt pathway by PTEN reduction and PIK3CA mRNA amplification contributes to cisplatin resistance in an ovarian cancer cell line.

WAF1, a potential mediator of p53 tumor suppression

PTEN tumor suppressor regulates p53 protein levels and activity through phosphatase-dependent and -independent mechanisms

PTEN: one gene, many syndromes

The protein kinase B/Akt signalling pathway in human malignancy

Proteasome inhibitors: valuable new tools for cell biologists

COX-2 inhibitor, NS398, enhances Fas-mediated apoptosis via modulation of the PTEN-Akt pathway in human gastric carcinoma cell lines.

P304

28609-28618

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1074/JBC.M703796200

http://www.w3.org/2001/XMLSchema#string

P407

P433

39

http://www.w3.org/2001/XMLSchema#string

P478

282

http://www.w3.org/2001/XMLSchema#string

P577

2007-08-07T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

17684018

http://www.w3.org/2001/XMLSchema#string

P921

P932

4610350

http://www.w3.org/2001/XMLSchema#string