Cysteine protease inhibitors as chemotherapy: lessons from a parasite target. - Wikidata - awgldk - TriplyDB

Cysteine protease inhibitors as chemotherapy: lessons from a parasite target.

Cysteine protease inhibitors as chemotherapy: lessons from a parasite target.

http://www.wikidata.org/entity/Q36176812

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Metamorphoses of malaria: the role of autophagy in parasite differentiation Recent developments in drug discovery for leishmaniasis and human African trypanosomiasis A comparative chemogenomics strategy to predict potential drug targets in the metazoan pathogen, Schistosoma mansoni In vitro and in vivo activity of a palladacycle complex on Leishmania (Leishmania) amazonensis Identification of semicarbazones, thiosemicarbazones and triazine nitriles as inhibitors of Leishmania mexicana cysteine protease CPB Drug discovery and the use of computational approaches for infectious diseases.Resistance of Entamoeba histolytica to the cysteine proteinase inhibitor E64 is associated with secretion of pro-enzymes and reduced pathogenicity.Secretory pathway of trypanosomatid parasites.Clinical and experimental advances in treatment of visceral leishmaniasis.Biochemical and genetic analysis of methylenetetrahydrofolate reductase in Leishmania metabolism and virulence.Identification of lead compounds targeting the cathepsin B-like enzyme of Eimeria tenella Identification of a disulfide isomerase protein of Leishmania major as a putative virulence factor.Aziridine-2,3-dicarboxylate-based cysteine cathepsin inhibitors induce cell death in Leishmania major associated with accumulation of debris in autophagy-related lysosome-like vacuoles.CPDB: cysteine protease annotation database in Leishmania species.Virulence of Leishmania major in macrophages and mice requires the gluconeogenic enzyme fructose-1,6-bisphosphatase Tissue localization of collagenase and leucine aminopeptidase in the bovine filarial parasite Setaria cervi A surface amebic cysteine proteinase inactivates interleukin-18.Promising therapeutic targets for antileishmanial drugs.Late endosomal Rab7 regulates lysosomal trafficking of endocytic but not biosynthetic cargo in Trypanosoma brucei.Molecular characterization of a cathepsin F-like protease in Trichinella spiralis Role of cystatins in tumor neovascularization.A major cathepsin B protease from the liver fluke Fasciola hepatica has atypical active site features and a potential role in the digestive tract of newly excysted juvenile parasites A potential role for ICP, a Leishmanial inhibitor of cysteine peptidases, in the interaction between host and parasite.Protein turnover and differentiation in Leishmania.Drug discovery and development for neglected parasitic diseases.A determination of the steady state lysosomal pH of bloodstream stage African trypanosomes.Overexpression of the natural inhibitor of cysteine peptidases in Leishmania mexicana leads to reduced virulence and a Th1 response Cysteine protease inhibition by nitrile-based inhibitors: a computational study.Autophagy in protists.Proteinases as virulence factors in Leishmania spp. infection in mammals.Specific recognition and cleavage of galectin-3 by Leishmania major through species-specific polygalactose epitope.Antiprotozoal activity of (E)-cinnamic N-acylhydrazone derivatives.A cathepsin B-like protease is required for host protein degradation in Trypanosoma brucei.Inhibition of fumarate reductase in Leishmania major and L. donovani by chalcones.α-ketoheterocycles as inhibitors of Leishmania mexicana cysteine protease CPB.Why strategies to control Leishmania spp. multiplication based on the use of proteinase inhibitors should consider multiple targets and not only a single enzyme.Identification and characterization of a cathepsin-L-like peptidase in Eimeria tenella.Expression and characterization of a recombinant cysteine proteinase of Leishmania mexicana.Identification of secreted cysteine proteases from the parasitic nematode Haemonchus contortus detected by biotinylated inhibitors.Secretory and endocytic pathways converge in a dynamic endosomal system in a primitive protozoan.

P2860

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P2860

Cysteine protease inhibitors as chemotherapy: lessons from a parasite target.

http://www.wikidata.org/entity/Q36176812

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Cysteine protease inhibitors as chemotherapy: lessons from a parasite target.

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Cysteine protease inhibitors as chemotherapy: lessons from a parasite target.

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Cysteine protease inhibitors as chemotherapy: lessons from a parasite target.

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Cysteine protease inhibitors as chemotherapy: lessons from a parasite target.

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B Ugele

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D G Russell

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I Hsieh

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J A Sakanari

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J C Engel

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J H McKerrow

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M Bogyo

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P M Selzer

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S Pingel

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V J Chan

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P2860

Cysteine protease inhibitors cure an experimental Trypanosoma cruzi infection

Roles of cysteine proteinases of trypanosomes and Leishmania in host-parasite interactions.

Structure-based inhibitor design by using protein models for the development of antiparasitic agents.

Leishmania major: molecular modeling of cysteine proteases and prediction of new nonpeptide inhibitors.

Endocytosis and secretion in trypanosomatid parasites - Tumultuous traffic in a pocket.

Evidence from disruption of the lmcpb gene array of Leishmania mexicana that cysteine proteinases are virulence factors.

Leishmania major: comparison of the cathepsin L- and B-like cysteine protease genes with those of other trypanosomatids.

Immunoelectron microscopy of endosomal trafficking in macrophages infected with microbial pathogens.

Substrate binding and sequence preference of the proteasome revealed by active-site-directed affinity probes.

Structure-based design of parasitic protease inhibitors.

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