p53 Activation by small molecules: application in oncology.
about
Nutlin-3a activates p53 to both down-regulate inhibitor of growth 2 and up-regulate mir-34a, mir-34b, and mir-34c expression, and induce senescenceDirect and Propagated Effects of Small Molecules on Protein-Protein Interaction NetworksSmall molecule compounds targeting the p53 pathway: are we finally making progress?Activation of the p53 pathway by small-molecule-induced MDM2 and MDMX dimerizationImplementation of a 220,000-compound HCS campaign to identify disruptors of the interaction between p53 and hDM2 and characterization of the confirmed hits.Selection and characterization of a novel agonistic human recombinant anti-TRAIL-R2 minibody with anti-leukemic activity.Design, synthesis, and evaluation of an alpha-helix mimetic library targeting protein-protein interactions.TGF-beta1-induced expression of human Mdm2 correlates with late-stage metastatic breast cancer.Discovery of 4-((3'R,4'S,5'R)-6″-Chloro-4'-(3-chloro-2-fluorophenyl)-1'-ethyl-2″-oxodispiro[cyclohexane-1,2'-pyrrolidine-3',3″-indoline]-5'-carboxamido)bicyclo[2.2.2]octane-1-carboxylic Acid (AA-115/APG-115): A Potent and Orally Active Murine DoubleCharacterization and optimization of a novel protein-protein interaction biosensor high-content screening assay to identify disruptors of the interactions between p53 and hDM2.Homology Modelling of Human E1 Ubiquitin Activating EnzymeMDM2 inhibitor MI-319 in combination with cisplatin is an effective treatment for pancreatic cancer independent of p53 functionPathologies associated with the p53 response.A computational analysis of the binding model of MDM2 with inhibitors.NF-kappaB activation enhances cell death by antimitotic drugs in human prostate cancer cells.Beta-peptides with improved affinity for hDM2 and hDMX.A p53-dependent promoter associated with polymorphic tandem repeats controls the expression of a viral transcript encoding clustered microRNAsWhole-body physiologically based pharmacokinetic model for nutlin-3a in mice after intravenous and oral administration.Protein-protein interactions for cancer therapySAR405838: an optimized inhibitor of MDM2-p53 interaction that induces complete and durable tumor regressionDisruption of focal adhesion kinase and p53 interaction with small molecule compound R2 reactivated p53 and blocked tumor growth.A small-molecule p53 activator induces apoptosis through inhibiting MDMX expression in breast cancer cells.Inflammation and p53: A Tale of Two StressesDrug-eluting microarrays to identify effective chemotherapeutic combinations targeting patient-derived cancer stem cellsNutlin-3 down-regulates retinoblastoma protein expression and inhibits muscle cell differentiation.Discovery of Novel Isatin-Based p53 InducersClassification of scaffold-hopping approachesAn evaluation of small-molecule p53 activators as chemoprotectants ameliorating adverse effects of anticancer drugs in normal cells.Wt p53 impairs response to chemotherapy: make lemonade to spare normal cellsDissecting p53-dependent apoptosis.PLK2 phosphorylates and inhibits enriched TAp73 in human osteosarcoma cellsRecent advances in targeting regulators of apoptosis in cancer cells for therapeutic gain.Ligand binding mode prediction by docking: mdm2/mdmx inhibitors as a case studyA small-molecule inhibitor, 5'-O-tritylthymidine, targets FAK and Mdm-2 interaction, and blocks breast and colon tumorigenesis in vivo.Dangerous habits of a security guard: the two faces of p53 as a drug target.A careful disorderliness in the proteome: sites for interaction and targets for future therapies.Protein-protein interactions as targets for small-molecule therapeutics in cancer.Elucidation of Acquired Resistance to Bcl-2 and MDM2 Inhibitors in Acute Leukemia In Vitro and In Vivo.Targeting the p53 pathway.Identification of a disruptor of the MDM2-p53 protein-protein interaction facilitated by high-throughput in silico docking.
P2860
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P2860
p53 Activation by small molecules: application in oncology.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
p53 Activation by small molecules: application in oncology.
@ast
p53 Activation by small molecules: application in oncology.
@en
type
label
p53 Activation by small molecules: application in oncology.
@ast
p53 Activation by small molecules: application in oncology.
@en
prefLabel
p53 Activation by small molecules: application in oncology.
@ast
p53 Activation by small molecules: application in oncology.
@en
P356
P1476
p53 Activation by small molecules: application in oncology.
@en
P2093
Lyubomir T Vassilev
P304
P356
10.1021/JM058174K
P407
P577
2005-07-01T00:00:00Z