Overexpression of angiotensin AT1 receptor transgene in the mouse myocardium produces a lethal phenotype associated with myocyte hyperplasia and heart block.
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Transient cardiac expression of constitutively active Galphaq leads to hypertrophy and dilated cardiomyopathy by calcineurin-dependent and independent pathwaysNovel Electrocardiographic Patterns for the Prediction of Hypertensive Disorders of Pregnancy--From Pathophysiology to Practical ImplicationsNuclear compartmentalization of α1-adrenergic receptor signaling in adult cardiac myocytesTrpm4 gene invalidation leads to cardiac hypertrophy and electrophysiological alterationsCardiac-specific overexpression of angiotensin II AT2 receptor causes attenuated response to AT1 receptor-mediated pressor and chronotropic effectsAkt-mediated cardiomyocyte survival pathways are compromised by G alpha q-induced phosphoinositide 4,5-bisphosphate depletionEmbryonic cardiomyocyte hypoplasia and craniofacial defects in G alpha q/G alpha 11-mutant mice.Cardiac-specific overexpression of AT1 receptor mutant lacking G alpha q/G alpha i coupling causes hypertrophy and bradycardia in transgenic mice.Conditional expression of a Gi-coupled receptor causes ventricular conduction delay and a lethal cardiomyopathy.Cardiac expression of a gain-of-function alpha(5)-integrin results in perinatal lethality.Cardiac-specific overexpression of RhoA results in sinus and atrioventricular nodal dysfunction and contractile failure.Beta-adrenergic receptor blockade arrests myocyte damage and preserves cardiac function in the transgenic G(salpha) mouseA positive feedback loop contributes to the deleterious effects of angiotensin.Promoter polymorphism G-6A, which modulates angiotensinogen gene expression, is associated with non-familial sick sinus syndromeG protein-coupled receptor signalling in in vivo cardiac overload.Cardiac hypertrophy and failure: lessons learned from genetically engineered mice.Cardiac 7-transmembrane-spanning domain receptor portfolios: diversify, diversify, diversify.Signal transduction mechanisms of the angiotensin II type AT(1)-receptor: looking beyond the heterotrimeric G protein paradigm.Overexpression of angiotensin II type I receptor in cardiomyocytes induces cardiac hypertrophy and remodeling.Role of cardiac overexpression of ANG II in the regulation of cardiac function and remodeling postmyocardial infarctionMice with cardiac-restricted angiotensin-converting enzyme (ACE) have atrial enlargement, cardiac arrhythmia, and sudden death.Vital role of the calpain-calpastatin system for placental-integrity-dependent embryonic survival.Is angiotensin II a direct mediator of left ventricular hypertrophy? Time for another look.In vivo investigation of estrogen regulation of adrenal and renal angiotensin (AT1) receptor expression by PETProtein kinase C (PKC)ζ-mediated Gαq stimulation of ERK5 protein pathway in cardiomyocytes and cardiac fibroblasts.Gain-of-function mutant of angiotensin II receptor, type 1A, causes hypertension and cardiovascular fibrosis in mice.Transforming Growth Factor-β1 T869C Gene Polymorphism Is Associated with Acquired Sick Sinus Syndrome via Linking a Higher Serum Protein LevelInternational Union of Basic and Clinical Pharmacology. XCIX. Angiotensin Receptors: Interpreters of Pathophysiological Angiotensinergic Stimuli [corrected].Enhanced Galphaq signaling: a common pathway mediates cardiac hypertrophy and apoptotic heart failure.Progressive hypertrophy and heart failure in beta1-adrenergic receptor transgenic mice.The tight junction protein CAR regulates cardiac conduction and cell-cell communication.A haplotype of angiotensin receptor type 1 associated with human hypertension increases blood pressure in transgenic miceGene dose-dependent atrial arrhythmias, heart block, and brady-cardiomyopathy in mice overexpressing A(3) adenosine receptorsARB and cardioprotection.Receptors and ionic transporters in nuclear membranes: new targets for therapeutical pharmacological interventions.An introduction to murine models of atrial fibrillationRegulation of cellular redox signaling by matricellular proteins in vascular biology, immunology, and cancerAttenuation of angiotensin II-induced hypertension and cardiac hypertrophy in transgenic mice overexpressing a type 1 receptor mutant.The MEK1-ERK1/2 signaling pathway promotes compensated cardiac hypertrophy in transgenic miceRegulation of the cell surface expression and function of angiotensin II type 1 receptor by Rab1-mediated endoplasmic reticulum-to-Golgi transport in cardiac myocytes.
P2860
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P2860
Overexpression of angiotensin AT1 receptor transgene in the mouse myocardium produces a lethal phenotype associated with myocyte hyperplasia and heart block.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
1997年论文
@zh
1997年论文
@zh-cn
name
Overexpression of angiotensin ...... e hyperplasia and heart block.
@ast
Overexpression of angiotensin ...... e hyperplasia and heart block.
@en
type
label
Overexpression of angiotensin ...... e hyperplasia and heart block.
@ast
Overexpression of angiotensin ...... e hyperplasia and heart block.
@en
prefLabel
Overexpression of angiotensin ...... e hyperplasia and heart block.
@ast
Overexpression of angiotensin ...... e hyperplasia and heart block.
@en
P2093
P2860
P356
P1476
Overexpression of angiotensin ...... e hyperplasia and heart block.
@en
P2093
P2860
P304
P356
10.1073/PNAS.94.12.6391
P407
P577
1997-06-01T00:00:00Z