Transient cardiac expression of constitutively active Galphaq leads to hypertrophy and dilated cardiomyopathy by calcineurin-dependent and independent pathways - Wikidata - awgldk - TriplyDB

Transient cardiac expression of constitutively active Galphaq leads to hypertrophy and dilated cardiomyopathy by calcineurin-dependent and independent pathways

Transient cardiac expression of constitutively active Galphaq leads to hypertrophy and dilated cardiomyopathy by calcineurin-dependent and independent pathways

http://www.wikidata.org/entity/Q24649132

about

Gq/11-mediated signaling and hypertrophy in mice with cardiac-specific transgenic expression of regulator of G-protein signaling 2 Targeted disruption of NFATc3, but not NFATc4, reveals an intrinsic defect in calcineurin-mediated cardiac hypertrophic growth Deregulation of RGS2 in cardiovascular diseases Targeted inhibition of calcineurin attenuates cardiac hypertrophy in vivo Statins as antioxidant therapy for preventing cardiac myocyte hypertrophy Akt-mediated cardiomyocyte survival pathways are compromised by G alpha q-induced phosphoinositide 4,5-bisphosphate depletion Deletion of low molecular weight protein tyrosine phosphatase (Acp1) protects against stress-induced cardiomyopathy.Calcineurin, a calcium/calmodulin-dependent protein phosphatase, is involved in movement, fertility, egg laying, and growth in Caenorhabditis elegans.Protease-activated receptor-1 contributes to cardiac remodeling and hypertrophy Cardiac-specific overexpression of RhoA results in sinus and atrioventricular nodal dysfunction and contractile failure.Regulation of cardiac hypertrophy in vivo by the stress-activated protein kinases/c-Jun NH(2)-terminal kinases.RGS4 causes increased mortality and reduced cardiac hypertrophy in response to pressure overload.Heterotrimeric G proteins in heart disease.Isoform- and tissue-specific regulation of the Ca(2+)-sensitive transcription factor NFAT in cardiac myocytes and heart failure.Meeting Koch's postulates for calcium signaling in cardiac hypertrophy.Heart-targeted overexpression of caspase3 in mice increases infarct size and depresses cardiac function.Cardiac overexpression of constitutively active Galpha q causes angiotensin II type1 receptor activation, leading to progressive heart failure and ventricular arrhythmias in transgenic mice Role of the sympathetic nervous system in cardiac remodeling in hypertension.In vivo functions of heterotrimeric G-proteins: studies in Galpha-deficient mice.Activation of NFATc1 is directly mediated by IP3 in adult cardiac myocytes Cardiac hypertrophy and failure: lessons learned from genetically engineered mice.Adrenergic regulation of cardiac myocyte apoptosis.Nicorandil prevents Gαq-induced progressive heart failure and ventricular arrhythmias in transgenic mice.Calcineurin and hypertrophic heart disease: novel insights and remaining questions.Calcineurin and cardiac hypertrophy: where have we been? Where are we going?Molecular mechanisms of phospholipase C β3 autoinhibition.Differential regulation of diacylglycerol kinase isoform in human failing hearts Activation of calcineurin in human failing heart ventricle by endothelin-1, angiotensin II and urotensin II Protease activated receptor-2 contributes to heart failure.Vascular failure: a hypothesis.CaM kinase signaling induces cardiac hypertrophy and activates the MEF2 transcription factor in vivo.Mechanotransduction in cardiac hypertrophy and failure.Cardiac GPCRs: GPCR signaling in healthy and failing hearts.Ventricular function during exercise in mice and rats Combined deep microRNA and mRNA sequencing identifies protective transcriptomal signature of enhanced PI3Kα signaling in cardiac hypertrophy.Chronic Contractile Dysfunction without Hypertrophy Does Not Provoke a Compensatory Transcriptional Response in Mouse Hearts.BDNF modulates heart contraction force and long-term homeostasis through truncated TrkB.T1 receptor activation Systematic Tracking of Disrupted Modules Identifies Altered Pathways Associated with Congenital Heart Defects in Down Syndrome.Repression of slow myosin heavy chain 2 gene expression in fast skeletal muscle fibers by muscarinic acetylcholine receptor and G(alpha)q signaling.NO triggers RGS4 degradation to coordinate angiogenesis and cardiomyocyte growth

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P2860

Transient cardiac expression of constitutively active Galphaq leads to hypertrophy and dilated cardiomyopathy by calcineurin-dependent and independent pathways

http://www.wikidata.org/entity/Q24649132

description

1998 nî lūn-bûn

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1998 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

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1998 թվականի նոյեմբերին հրատարակված գիտական հոդված

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1998年の論文

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Transient cardiac expression o ...... ndent and independent pathways

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Transient cardiac expression o ...... ndent and independent pathways

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Transient cardiac expression o ...... ndent and independent pathways

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Transient cardiac expression o ...... ndent and independent pathways

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Transient cardiac expression o ...... ndent and independent pathways

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Transient cardiac expression o ...... ndent and independent pathways

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A Kagen

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E J Neer

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P2860

Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications

Cleavage of structural proteins during the assembly of the head of bacteriophage T4

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

A calcineurin-dependent transcriptional pathway for cardiac hypertrophy

Expression of the transcription factor NFATp in a neuronal cell line and in the murine nervous system

Sites for Galpha binding on the G protein beta subunit overlap with sites for regulation of phospholipase Cbeta and adenylyl cyclase.

Posttranscriptional modification of myosin heavy-chain gene expression in the hypertrophied rat myocardium.

Myocardial expression of a constitutively active alpha 1B-adrenergic receptor in transgenic mice induces cardiac hypertrophy

Overexpression of angiotensin AT1 receptor transgene in the mouse myocardium produces a lethal phenotype associated with myocyte hyperplasia and heart block.

Developmental regulation of myosin gene expression in mouse cardiac muscle

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