Agonist-induced closure of constitutively open gamma-aminobutyric acid channels with mutated M2 domains.
about
Identification of a tyrosine in the agonist binding site of the homomeric rho1 gamma-aminobutyric acid (GABA) receptor that, when mutated, produces spontaneous openingNeuronal nicotinic receptors: from protein structure to functionAllosteric activation mechanism of the cys-loop receptorsMapping the rho1 GABA(C) receptor agonist binding pocket. Constructing a complete modelModulation of the human ρ1 GABAA receptor by inhibitory steroids.Multiple roles for the first transmembrane domain of GABAA receptor subunits in neurosteroid modulation and spontaneous channel activity.Allosteric activation mechanism of the alpha 1 beta 2 gamma 2 gamma-aminobutyric acid type A receptor revealed by mutation of the conserved M2 leucine.Charged residues at the 2' position of human GABAC rho 1 receptors invert ion selectivity and influence open state probability.Mutation at the putative GABA(A) ion-channel gate reveals changes in allosteric modulation.Molecular determinants of ivermectin sensitivity at the glycine receptor chloride channelIdentification of an Inhibitory Alcohol Binding Site in GABAA ρ1 ReceptorsAn engineered glutamate-gated chloride (GluCl) channel for sensitive, consistent neuronal silencing by ivermectin.A single amino acid in the second transmembrane domain of GABA rho subunits is a determinant of the response kinetics of GABAC receptors.Expression of GABA(C) receptor rho1 and rho2 subunits during development of the mouse retina.Permeability and single channel conductance of human homomeric rho1 GABAC receptors.Studies on the mechanisms of action of picrotoxin, quercetin and pregnanolone at the GABA rho 1 receptor.Structural and electrostatic properties of the 5-HT3 receptor pore revealed by substituted cysteine accessibility mutagenesis.Two novel residues in M2 of the gamma-aminobutyric acid type A receptor affecting gating by GABA and picrotoxin affinity.Anesthetic and ethanol effects on spontaneously opening glycine receptor channels.Antagonistic effect of dopamine structural analogues on human GABAρ1 receptor.Evidence for coassembly of mutant GABAC rho1 with GABAA gamma2S, glycine alpha1 and glycine alpha2 receptor subunits in vitro.
P2860
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P2860
Agonist-induced closure of constitutively open gamma-aminobutyric acid channels with mutated M2 domains.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年論文
@yue
1997年論文
@zh-hant
1997年論文
@zh-hk
1997年論文
@zh-mo
1997年論文
@zh-tw
1997年论文
@wuu
1997年论文
@zh
1997年论文
@zh-cn
name
Agonist-induced closure of con ...... nnels with mutated M2 domains.
@ast
Agonist-induced closure of con ...... nnels with mutated M2 domains.
@en
type
label
Agonist-induced closure of con ...... nnels with mutated M2 domains.
@ast
Agonist-induced closure of con ...... nnels with mutated M2 domains.
@en
prefLabel
Agonist-induced closure of con ...... nnels with mutated M2 domains.
@ast
Agonist-induced closure of con ...... nnels with mutated M2 domains.
@en
P2093
P2860
P356
P1476
Agonist-induced closure of con ...... nnels with mutated M2 domains.
@en
P2093
P2860
P304
P356
10.1073/PNAS.94.12.6490
P407
P577
1997-06-01T00:00:00Z