Mutation at the putative GABA(A) ion-channel gate reveals changes in allosteric modulation.
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International Union of Pharmacology. LXX. Subtypes of gamma-aminobutyric acid(A) receptors: classification on the basis of subunit composition, pharmacology, and function. UpdateIdentification of a tyrosine in the agonist binding site of the homomeric rho1 gamma-aminobutyric acid (GABA) receptor that, when mutated, produces spontaneous openingEvidence for the formation of functionally distinct alphabetagammaepsilon GABA(A) receptorsMethionine 286 in transmembrane domain 3 of the GABAA receptor beta subunit controls a binding cavity for propofol and other alkylphenol general anestheticsPoint mutation in the first transmembrane region of the beta 2 subunit of the gamma--aminobutyric acid type A receptor alters desensitization kinetics of gamma--aminobutyric acid- and anesthetic-induced channel gatingThe Concise Guide to PHARMACOLOGY 2013/14: ligand-gated ion channels.Charged residues at the 2' position of human GABAC rho 1 receptors invert ion selectivity and influence open state probability.Allosteric modulators induce distinct movements at the GABA-binding site interface of the GABA-A receptor.Tryptophan scanning mutagenesis in TM2 of the GABA(A) receptor alpha subunit: effects on channel gating and regulation by ethanol.Different residues in the GABAA receptor benzodiazepine binding pocket mediate benzodiazepine efficacy and binding.Mutations of L293 in transmembrane two of the mouse 5-hydroxytryptamine3A receptor alter gating and alcohol modulatory actionsThe atypical cation-conduction and gating properties of ELIC underscore the marked functional versatility of the pentameric ligand-gated ion-channel fold.Desformylflustrabromine Modulates α4β2 Neuronal Nicotinic Acetylcholine Receptor High- and Low-Sensitivity Isoforms at Allosteric Clefts Containing the β2 SubunitMapping convulsants' binding to the GABA-A receptor chloride ionophore: a proposed model for channel binding sites.An engineered glutamate-gated chloride (GluCl) channel for sensitive, consistent neuronal silencing by ivermectin.Context dependent benzodiazepine modulation of GABA(A) receptor opening frequencyGating allosterism at a single class of etomidate sites on alpha1beta2gamma2L GABA A receptors accounts for both direct activation and agonist modulation.N-Methyl-D-aspartate receptor subtype-selectivity of homoquinolinate: an electrophysiological and radioligand binding study using both native and recombinant receptors.Allosteric modulators affect the efficacy of partial agonists for recombinant GABA(A) receptors.A spontaneous tonic chloride conductance in solitary glutamatergic hippocampal neurons.Loose protein packing around the extracellular half of the GABA(A) receptor beta1 subunit M2 channel-lining segment.Two novel residues in M2 of the gamma-aminobutyric acid type A receptor affecting gating by GABA and picrotoxin affinity.Anesthetic and ethanol effects on spontaneously opening glycine receptor channels.GABAA receptors activate fish feeding behaviour via two distinct functional pathways.High constitutive activity accounts for the combination of enhanced direct activation and reduced potentiation in mutated GABAA receptors.Microscopic kinetic determinants of macroscopic currents: insights from coupling and uncoupling of GABAA receptor desensitization and deactivation.
P2860
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P2860
Mutation at the putative GABA(A) ion-channel gate reveals changes in allosteric modulation.
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
1999年论文
@zh
1999年论文
@zh-cn
name
Mutation at the putative GABA( ...... nges in allosteric modulation.
@ast
Mutation at the putative GABA( ...... nges in allosteric modulation.
@en
type
label
Mutation at the putative GABA( ...... nges in allosteric modulation.
@ast
Mutation at the putative GABA( ...... nges in allosteric modulation.
@en
prefLabel
Mutation at the putative GABA( ...... nges in allosteric modulation.
@ast
Mutation at the putative GABA( ...... nges in allosteric modulation.
@en
P2093
P2860
P356
P1476
Mutation at the putative GABA( ...... nges in allosteric modulation.
@en
P2093
Thompson SA
Wafford KA
Whiting PJ
Wingrove PB
P2860
P304
P356
10.1038/SJ.BJP.0702687
P407
P577
1999-07-01T00:00:00Z