Conversion of proinsulin to insulin occurs coordinately with acidification of maturing secretory vesicles
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Insulin solubility transitions by pH-dependent interactions with proinsulin C-peptideDifferences between the catalytic properties of recombinant human PC2 and endogenous rat PC2INS-gene mutations: from genetics and beta cell biology to clinical diseaseA role for glutamate transporters in the regulation of insulin secretionLethality of PE2 incorporation into Sindbis virus can be suppressed by second-site mutations in E3 and E2Functional and structural characterization of a dense core secretory granule sorting domain from the PC1/3 proteaseThe low pH in trans-Golgi triggers autocatalytic cleavage of pre-alpha -inhibitor heavy chain precursorResponse of an integral granule membrane protein to changes in pHInsulin biosynthetic interaction network component, TMEM24, facilitates insulin reserve pool releaseIntracellular transport and secretion of salivary proteins.Acquisition of Lubrol insolubility, a common step for growth hormone and prolactin in the secretory pathway of neuroendocrine cells.Role for intracellular proteases in the processing and transport of class II HLA antigens.Evidence for the existence of secretory granule (dense-core vesicle)-based inositol 1,4,5-trisphosphate-dependent Ca2+ signaling system in astrocytesSecretory granules in inositol 1,4,5-trisphosphate-dependent Ca2+ signaling in the cytoplasm of neuroendocrine cells.Structural localization of the E3 glycoprotein in attenuated Sindbis virus mutants.Elemental composition of secretory granules in pancreatic islets of Langerhans.Virulent and avirulent strains of Francisella tularensis prevent acidification and maturation of their phagosomes and escape into the cytoplasm in human macrophages.V-ATPase-mediated granular acidification is regulated by the V-ATPase accessory subunit Ac45 in POMC-producing cellsThyrotropin induces the acidification of the secretory granules of parafollicular cells by increasing the chloride conductance of the granular membrane.HID-1, a new component of the peptidergic signaling pathway.Proinsulin endoproteolysis confers enhanced targeting of processed insulin to the regulated secretory pathwayMutant proinsulin that cannot be converted is secreted efficiently from primary rat beta-cells via the regulated pathway.The vacuolar-ATPase modulates matrix metalloproteinase isoforms in human pancreatic cancerTopographic abnormalities of proinsulin to insulin conversion in functioning human insulinomas. Comparison of immunoelectron microscopic and clinical data.Noninvasive measurement of the pH of the endoplasmic reticulum at rest and during calcium release.Applications of immunogold labeling in ultrastructural pathology.A view of acidic intracellular compartments.Efficient targeting to storage granules of human proinsulins with altered propeptide domain.The propeptide of preprosomatostatin mediates intracellular transport and secretion of alpha-globin from mammalian cellsImmunocytochemistry of calciosomes in liver and pancreas.Retrovirus-mediated expression of preprosomatostatin: posttranslational processing, intracellular storage, and secretion in GH3 pituitary cells.Prohormone processing in the trans-Golgi network: endoproteolytic cleavage of prosomatostatin and formation of nascent secretory vesicles in permeabilized cellsDistinct molecular mechanisms for protein sorting within immature secretory granules of pancreatic beta-cells.pH-independent and -dependent cleavage of proinsulin in the same secretory vesicle.Transport via the regulated secretory pathway in semi-intact PC12 cells: role of intra-cisternal calcium and pH in the transport and sorting of secretogranin II.Differential sorting of lysosomal enzymes out of the regulated secretory pathway in pancreatic beta-cellsDense-core secretory granule biogenesis.Targeting of frog prodermorphin to the regulated secretory pathway by fusion to proenkephalin.Involvement of the stress protein HSP47 in procollagen processing in the endoplasmic reticulum.Proteolysis of the major yolk glycoproteins is regulated by acidification of the yolk platelets in sea urchin embryos
P2860
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P2860
Conversion of proinsulin to insulin occurs coordinately with acidification of maturing secretory vesicles
description
1986 nî lūn-bûn
@nan
1986年の論文
@ja
1986年論文
@yue
1986年論文
@zh-hant
1986年論文
@zh-hk
1986年論文
@zh-mo
1986年論文
@zh-tw
1986年论文
@wuu
1986年论文
@zh
1986年论文
@zh-cn
name
Conversion of proinsulin to in ...... of maturing secretory vesicles
@ast
Conversion of proinsulin to in ...... of maturing secretory vesicles
@en
type
label
Conversion of proinsulin to in ...... of maturing secretory vesicles
@ast
Conversion of proinsulin to in ...... of maturing secretory vesicles
@en
prefLabel
Conversion of proinsulin to in ...... of maturing secretory vesicles
@ast
Conversion of proinsulin to in ...... of maturing secretory vesicles
@en
P2093
P2860
P356
P1476
Conversion of proinsulin to in ...... of maturing secretory vesicles
@en
P2093
A Perrelet
J D Vassalli
M Ravazzola
R G Anderson
P2860
P304
P356
10.1083/JCB.103.6.2273
P407
P433
P577
1986-12-01T00:00:00Z