Use of DNA sequence and mutant analyses and antisense oligodeoxynucleotides to examine the molecular basis of nonmuscle myosin light chain kinase autoinhibition, calmodulin recognition, and activity.
about
Telokin (kinase-related protein) modulates the oligomeric state of smooth-muscle myosin light-chain kinase and its interaction with myosin filamentsKinase-related protein (telokin) is phosphorylated by smooth-muscle myosin light-chain kinase and modulates the kinase activityRegulation of cell motility by mitogen-activated protein kinaseStructure and expression of a calcium-binding protein gene contained within a calmodulin-regulated protein kinase geneRegulation of myosin light chain kinase and telokin expression in smooth muscle tissuesStructural analysis of myosin heavy chain kinase A from Dictyostelium. Evidence for a highly divergent protein kinase domain, an amino-terminal coiled-coil domain, and a domain homologous to the beta-subunit of heterotrimeric G proteinsThe Caenorhabditis elegans gene unc-89, required fpr muscle M-line assembly, encodes a giant modular protein composed of Ig and signal transduction domainsRole of the N-terminal region of the skeletal muscle myosin light chain kinase target sequence in its interaction with calmodulin.Regulatory mechanism of Ca2+/calmodulin-dependent protein kinase kinase.A protein kinase associated with apoptosis and tumor suppression: structure, activity, and discovery of peptide substrates.Molecular characterization of a mammalian smooth muscle myosin light chain kinase.Rho-kinase-mediated Ca2+-independent contraction in rat embryo fibroblastsSmooth muscle myosin light chain kinase expression in cardiac and skeletal muscle.A molecular mechanism for autoinhibition of myosin light chain kinasesIdentification of basic residues involved in activation and calmodulin binding of rabbit smooth muscle myosin light chain kinase.Biochemical properties of chimeric skeletal and smooth muscle myosin light chain kinases.Expression of a novel myosin light chain kinase in embryonic tissues and cultured cells.DAP kinase and DAP-3: novel positive mediators of apoptosisMyosin light chain kinase in microvascular endothelial barrier function.An integrated mathematical model of thrombin-, histamine-and VEGF-mediated signalling in endothelial permeability.Additional sequence complexity in the muscle gene, unc-22, and its encoded protein, twitchin, of Caenorhabditis elegansDAP-kinase: from functional gene cloning to establishment of its role in apoptosis and cancer.Analysis of the molecular basis of calmodulin defects that affect ion channel-mediated cellular responses: site-specific mutagenesis and microinjectionDeath-associated protein kinase as a potential therapeutic target.In vivo phosphorylation of regulatory light chain of myosin II during mitosis of cultured cellsLocalization and activity of myosin light chain kinase isoforms during the cell cycle.Microinjection of the catalytic fragment of myosin light chain kinase into dividing cells: effects on mitosis and cytokinesis3'-modified antisense oligodeoxyribonucleotides complementary to calmodulin mRNA alter behavioral responses in Paramecium.Myosin light chain kinase (MLCK) gene disruption in Dictyostelium: a role for MLCK-A in cytokinesis and evidence for multiple MLCKsRegulation of 130-kDa smooth muscle myosin light chain kinase expression by an intronic CArG element.Drosophila has a twitchin/titin-related gene that appears to encode projectin.Design of peptidase-resistant peptide inhibitors of myosin light chain kinase.Pseudosubstrate sequence may not be critical for autoinhibition of smooth muscle myosin light chain kinase.Kettin, a large modular protein in the Z-disc of insect musclesTowards a molecular understanding of titin.DAP-kinase is a Ca2+/calmodulin-dependent, cytoskeletal-associated protein kinase, with cell death-inducing functions that depend on its catalytic activity.Phosphorylation of myosin II regulatory light chain is necessary for migration of HeLa cells but not for localization of myosin II at the leading edgeBiochemical and pharmacological studies with KT7692 and LY294002 on the role of phosphatidylinositol 3-kinase in Fc epsilon RI-mediated signal transduction.Non-muscle and smooth muscle myosin light chain kinases: no end in sight.Multiple gene products are produced from a novel protein kinase transcription region.
P2860
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P2860
Use of DNA sequence and mutant analyses and antisense oligodeoxynucleotides to examine the molecular basis of nonmuscle myosin light chain kinase autoinhibition, calmodulin recognition, and activity.
description
1990 nî lūn-bûn
@nan
1990年の論文
@ja
1990年学术文章
@wuu
1990年学术文章
@zh-cn
1990年学术文章
@zh-hans
1990年学术文章
@zh-my
1990年学术文章
@zh-sg
1990年學術文章
@yue
1990年學術文章
@zh
1990年學術文章
@zh-hant
name
Use of DNA sequence and mutant ...... lin recognition, and activity.
@ast
Use of DNA sequence and mutant ...... lin recognition, and activity.
@en
type
label
Use of DNA sequence and mutant ...... lin recognition, and activity.
@ast
Use of DNA sequence and mutant ...... lin recognition, and activity.
@en
prefLabel
Use of DNA sequence and mutant ...... lin recognition, and activity.
@ast
Use of DNA sequence and mutant ...... lin recognition, and activity.
@en
P2093
P2860
P356
P1476
Use of DNA sequence and mutant ...... lin recognition, and activity.
@en
P2093
A P Kwiatkowski
D M Watterson
L Guerra-Santos
L J Van Eldik
M O Shoemaker
P E Matrisian
R L Shattuck
P2860
P304
P356
10.1083/JCB.111.3.1107
P407
P577
1990-09-01T00:00:00Z