A dose-dependent requirement for the proline motif of CD28 in cellular and humoral immunity revealed by a targeted knockin mutant.
about
Factors regulating immunoglobulin production by normal and disease-associated plasma cellsBurrowing through the Heterogeneity: Review of Mouse Models of PTCL-NOSStrong CD28 costimulation suppresses induction of regulatory T cells from naive precursors through Lck signalingQuantitative analysis by surface plasmon resonance of CD28 interaction with cytoplasmic adaptor molecules Grb2, Gads and p85 PI3K.Signals and sequences that control CD28 localization to the central region of the immunological synapse.CD28-mediated pro-survival signaling induces chemotherapeutic resistance in multiple myelomaCD28 facilitates the generation of Foxp3(-) cytokine responsive regulatory T cell precursors.An enigmatic tail of CD28 signaling.Cutting edge: CD28 and c-Rel-dependent pathways initiate regulatory T cell development.Sustained antibody responses depend on CD28 function in bone marrow-resident plasma cellsCD28 Promotes Plasma Cell Survival, Sustained Antibody Responses, and BLIMP-1 Upregulation through Its Distal PYAP Proline Motif4-1BB costimulation ameliorates T cell exhaustion induced by tonic signaling of chimeric antigen receptorsInduction of autoimmune disease in CTLA-4-/- mice depends on a specific CD28 motif that is required for in vivo costimulation.Airway epithelial cells suppress T cell proliferation by an IFNγ/STAT1/TGFβ-dependent mechanism.CD28 promotes CD4+ T cell clonal expansion during infection independently of its YMNM and PYAP motifs.mTOR at the crossroads of T cell proliferation and tolerance.In the absence of its cytosolic domain, the CD28 molecule still contributes to T cell activation.Targeted knock-in mice expressing mutations of CD28 reveal an essential pathway for costimulationCD28 Costimulation: From Mechanism to Therapy.Cutting edge: A double-mutant knockin of the CD28 YMNM and PYAP motifs reveals a critical role for the YMNM motif in regulation of T cell proliferation and Bcl-xL expression.Binding of the cytoplasmic domain of CD28 to the plasma membrane inhibits Lck recruitment and signaling.CD28 and inducible costimulator (ICOS) signalling can sustain CD154 expression on activated T cells.CD28 signaling in primary CD4(+) T cells: identification of both tyrosine phosphorylation-dependent and phosphorylation-independent pathways.
P2860
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P2860
A dose-dependent requirement for the proline motif of CD28 in cellular and humoral immunity revealed by a targeted knockin mutant.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
A dose-dependent requirement f ...... by a targeted knockin mutant.
@ast
A dose-dependent requirement f ...... by a targeted knockin mutant.
@en
type
label
A dose-dependent requirement f ...... by a targeted knockin mutant.
@ast
A dose-dependent requirement f ...... by a targeted knockin mutant.
@en
prefLabel
A dose-dependent requirement f ...... by a targeted knockin mutant.
@ast
A dose-dependent requirement f ...... by a targeted knockin mutant.
@en
P2093
P2860
P356
P1476
A dose-dependent requirement f ...... by a targeted knockin mutant.
@en
P2093
Christine Deppong
Christine M Rose
Dulari D Shah
Jonathan M Green
Joseph Lin
Lindzy D Friend
Traci L Bricker
Twyla I Juehne
P2860
P304
P356
10.1084/JEM.20052230
P407
P577
2006-08-14T00:00:00Z