Functional role of the cytoplasmic domain of the integrin alpha 5 subunit.
about
A novel integrin-linked kinase-binding protein, affixin, is involved in the early stage of cell-substrate interactionA molecular smart surface for spatio-temporal studies of cell mobilityThe integrin alpha 7 cytoplasmic domain regulates cell migration, lamellipodia formation, and p130CAS/Crk couplingSpecific association of CD63 with the VLA-3 and VLA-6 integrinsalpha1 Integrin cytoplasmic domain is involved in focal adhesion formation via association with intracellular proteinsNischarin, a novel protein that interacts with the integrin alpha5 subunit and inhibits cell migrationCD151 restricts the α6 integrin diffusion mode.Cardiac expression of a gain-of-function alpha(5)-integrin results in perinatal lethality.The alpha 5 beta 1 integrin supports survival of cells on fibronectin and up-regulates Bcl-2 expression.Alpha1B-adrenoceptor signaling and cell motility: GTPase function of Gh/transglutaminase 2 inhibits cell migration through interaction with cytoplasmic tail of integrin alpha subunits.A first-in-human study of the anti-α5β1 integrin monoclonal antibody PF-04605412 administered intravenously to patients with advanced solid tumors.Regulation of cellular interactions with laminin by integrin cytoplasmic domains: the A and B structural variants of the alpha 6 beta 1 integrin differentially modulate the adhesive strength, morphology, and migration of macrophages.Integrin alpha 2 cytoplasmic domain deletion effects: loss of adhesive activity parallels ligand-independent recruitment into focal adhesions.Specialized functional properties of the integrin alpha 4 cytoplasmic domain.Assembly and function of integrin receptors is dependent on opposing alpha and beta cytoplasmic domainsalpha5beta1 integrin protects intestinal epithelial cells from apoptosis through a phosphatidylinositol 3-kinase and protein kinase B-dependent pathwayVolociximab, a chimeric monoclonal antibody that specifically binds alpha5beta1 integrin: a phase I, pharmacokinetic, and biological correlative study.Isolation of a highly specific ligand for the alpha 5 beta 1 integrin from a phage display library.Single subunit chimeric integrins as mimics and inhibitors of endogenous integrin functions in receptor localization, cell spreading and migration, and matrix assembly.Integrin-mediated activation of MAP kinase is independent of FAK: evidence for dual integrin signaling pathways in fibroblasts.Requirement of the NPXY motif in the integrin beta 3 subunit cytoplasmic tail for melanoma cell migration in vitro and in vivo.Regulation of alpha 6 beta 1 integrin laminin receptor function by the cytoplasmic domain of the alpha 6 subunit.Modulation of in vivo migratory function of alpha 2 beta 1 integrin in mouse liverCloning and characterization of chicken α5 integrin: endogenous and experimental expression in early chicken embryos.Regulation of integrin affinity states through an NPXY motif in the beta subunit cytoplasmic domain.The cytoplasmic domain of the alpha-subunit of glycoprotein (GP) Ib mediates attachment of the entire GP Ib-IX complex to the cytoskeleton and regulates von Willebrand factor-induced changes in cell morphology.Stable interaction between alpha5beta1 integrin and Tie2 tyrosine kinase receptor regulates endothelial cell response to Ang-1.Integrin alpha5/beta1 expression mediates HER-2 down-regulation in colon cancer cells.Reduced cell attachment and phosphorylation of focal adhesion kinase associated with expression of a mutant insulin receptor.ADP-ribosylation of the G protein Rho inhibits integrin regulation of tumor cell growth.Adeno-associated virus type 2 contains an integrin alpha5beta1 binding domain essential for viral cell entryModulation of integrin activity is vital for morphogenesisA membrane proximal region of the integrin alpha5 subunit is important for its interaction with nischarin.The two phenylalanines in the GFFKR motif of the integrin alpha6A subunit are essential for heterodimerization.Phospholipase Cgamma binds alpha1beta1 integrin and modulates alpha1beta1 integrin-specific adhesion.Effects of β Subunit Cytoplasmic Domain Deletions on the Recruitment of the Integrin αvβ6 to Focal Contacts
P2860
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P2860
Functional role of the cytoplasmic domain of the integrin alpha 5 subunit.
description
1993 nî lūn-bûn
@nan
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
1993年论文
@zh
1993年论文
@zh-cn
name
Functional role of the cytoplasmic domain of the integrin alpha 5 subunit.
@ast
Functional role of the cytoplasmic domain of the integrin alpha 5 subunit.
@en
type
label
Functional role of the cytoplasmic domain of the integrin alpha 5 subunit.
@ast
Functional role of the cytoplasmic domain of the integrin alpha 5 subunit.
@en
prefLabel
Functional role of the cytoplasmic domain of the integrin alpha 5 subunit.
@ast
Functional role of the cytoplasmic domain of the integrin alpha 5 subunit.
@en
P2093
P2860
P356
P1476
Functional role of the cytoplasmic domain of the integrin alpha 5 subunit.
@en
P2093
C Schreiner
L Kornberg
R L Juliano
R Nicholas
P2860
P304
P356
10.1083/JCB.122.1.209
P407
P577
1993-07-01T00:00:00Z