Distinct functions of integrin alpha and beta subunit cytoplasmic domains in cell spreading and formation of focal adhesions.
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The p16(INK4a) tumour suppressor protein inhibits alphavbeta3 integrin-mediated cell spreading on vitronectin by blocking PKC-dependent localization of alphavbeta3 to focal contacts.Collagen and collagenase gene expression in three-dimensional collagen lattices are differentially regulated by alpha 1 beta 1 and alpha 2 beta 1 integrinsIdentification of a novel calcium-binding protein that interacts with the integrin alphaIIb cytoplasmic domainIdentification of novel interaction partners for the conserved membrane proximal region of alpha-integrin cytoplasmic domainsPDZ interaction sites in integrin alpha subunits. T14853, TIP/GIPC binds to a type I recognition sequence in alpha 6A/alpha 5 and a novel sequence in alpha 6BIncreased filamin binding to beta-integrin cytoplasmic domains inhibits cell migrationBeta 1D integrin displaces the beta 1A isoform in striated muscles: localization at junctional structures and signaling potential in nonmuscle cellsIdentification of an interaction between the m-band protein skelemin and beta-integrin subunits. Colocalization of a skelemin-like protein with beta1- and beta3-integrins in non-muscle cellsCalpain cleavage of the cytoplasmic domain of the integrin beta 3 subunitThe role of conserved amino acid motifs within the integrin beta3 cytoplasmic domain in triggering focal adhesion kinase phosphorylationGreen fluorescent protein (GFP) tagged to the cytoplasmic tail of alphaIIb or beta3 allows the expression of a fully functional integrin alphaIIb(beta3): effect of beta3GFP on alphaIIb(beta3) ligand bindingalpha1 Integrin cytoplasmic domain is involved in focal adhesion formation via association with intracellular proteinsDifferential dynamics of alpha 5 integrin, paxillin, and alpha-actinin during formation and disassembly of adhesions in migrating cellsQuantitative changes in integrin and focal adhesion signaling regulate myoblast cell cycle withdrawal.Regulation of the pp72syk protein tyrosine kinase by platelet integrin alpha IIb beta 3Phosphorylation of a conserved integrin alpha 3 QPSXXE motif regulates signaling, motility, and cytoskeletal engagement.Integrin αII b tail distal of GFFKR participates in inside-out αII b β3 activation.L718P mutation in the membrane-proximal cytoplasmic tail of beta 3 promotes abnormal alpha IIb beta 3 clustering and lipid microdomain coalescence, and associates with a thrombasthenia-like phenotypeDisruption of the mouse mu-calpain gene reveals an essential role in platelet functionA splice variant of alpha 6 integrin is associated with malignant conversion in mouse skin tumorigenesisBlocking the alpha 4 integrin-paxillin interaction selectively impairs mononuclear leukocyte recruitment to an inflammatory siteRegulation of cellular interactions with laminin by integrin cytoplasmic domains: the A and B structural variants of the alpha 6 beta 1 integrin differentially modulate the adhesive strength, morphology, and migration of macrophages.Integrin alpha 2 cytoplasmic domain deletion effects: loss of adhesive activity parallels ligand-independent recruitment into focal adhesions.Integrin beta 1 cytoplasmic domain dominant negative effects revealed by lysophosphatidic acid treatment.Specialized functional properties of the integrin alpha 4 cytoplasmic domain.Assembly and function of integrin receptors is dependent on opposing alpha and beta cytoplasmic domainsProtein kinase C regulates the recruitment of syndecan-4 into focal contactsIntegrins regulate microtubule nucleating activity of centrosome through mitogen-activated protein kinase/extracellular signal-regulated kinase kinase/extracellular signal-regulated kinase (MEK/ERK) signaling.The antithrombotic potential of selective blockade of talin-dependent integrin alpha IIb beta 3 (platelet GPIIb-IIIa) activation.Requirement of alpha and beta subunit transmembrane helix separation for integrin outside-in signaling.Perturbing integrin function inhibits microtubule growth from centrosomes, spindle assembly, and cytokinesis.CD98hc (SLC3A2) participates in fibronectin matrix assembly by mediating integrin signaling.The interaction of Gα13 with integrin β1 mediates cell migration by dynamic regulation of RhoAIntegrins as regulators of the mitotic machinery.Integrin cytoplasmic domains mediate inside-out signal transduction.Single subunit chimeric integrins as mimics and inhibitors of endogenous integrin functions in receptor localization, cell spreading and migration, and matrix assembly.Modulation of cell migration by integrin-mediated cytoskeletal linkages and ligand-binding affinity.Muscle beta1D integrin reinforces the cytoskeleton-matrix link: modulation of integrin adhesive function by alternative splicing.Presentation of integrins on leukocyte microvilli: a role for the extracellular domain in determining membrane localizationActivated R-ras, Rac1, PI 3-kinase and PKCepsilon can each restore cell spreading inhibited by isolated integrin beta1 cytoplasmic domains.
P2860
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P2860
Distinct functions of integrin alpha and beta subunit cytoplasmic domains in cell spreading and formation of focal adhesions.
description
1993 nî lūn-bûn
@nan
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
1993年论文
@zh
1993年论文
@zh-cn
name
Distinct functions of integrin ...... formation of focal adhesions.
@ast
Distinct functions of integrin ...... formation of focal adhesions.
@en
type
label
Distinct functions of integrin ...... formation of focal adhesions.
@ast
Distinct functions of integrin ...... formation of focal adhesions.
@en
prefLabel
Distinct functions of integrin ...... formation of focal adhesions.
@ast
Distinct functions of integrin ...... formation of focal adhesions.
@en
P2093
P2860
P356
P1476
Distinct functions of integrin ...... d formation of focal adhesions
@en
P2093
P2860
P304
P356
10.1083/JCB.122.1.223
P407
P50
P577
1993-07-01T00:00:00Z