D-2-hydroxyglutarate produced by mutant IDH1 perturbs collagen maturation and basement membrane function. - Wikidata - awgldk - TriplyDB

D-2-hydroxyglutarate produced by mutant IDH1 perturbs collagen maturation and basement membrane function.

D-2-hydroxyglutarate produced by mutant IDH1 perturbs collagen maturation and basement membrane function.

http://www.wikidata.org/entity/Q36240913

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Molecular Imaging of Metabolic Reprograming in Mutant IDH Cells Epigenetic regulators and their impact on therapy in acute myeloid leukemia New developments in the pathogenesis and therapeutic targeting of the IDH1 mutation in glioma IDH1/2 mutations target a key hallmark of cancer by deregulating cellular metabolism in glioma Isocitrate dehydrogenase mutations: new opportunities for translational research Contemporary murine models in preclinical astrocytoma drug development IDH mutations in tumorigenesis and their potential role as novel therapeutic targets.An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells.Metabolic consequences of oncogenic IDH mutations 2-Hydoxyglutarate: D/Riving Pathology in gLiomaS IDH1 regulates phospholipid metabolism in developing astrocytes In vitro visualization and characterization of wild type and mutant IDH homo- and heterodimers using Bimolecular Fluorescence Complementation.Hominoid-specific enzyme GLUD2 promotes growth of IDH1R132H glioma Mutations in CIC and IDH1 cooperatively regulate 2-hydroxyglutarate levels and cell clonogenicity Oncometabolites: linking altered metabolism with cancer.Genomic insights into cancer-associated aberrant CpG island hypermethylation Glial progenitors as targets for transformation in glioma.The emerging nexus of active DNA demethylation and mitochondrial oxidative metabolism in post-mitotic neurons Genetic dissection of leukemia-associated IDH1 and IDH2 mutants and D-2-hydroxyglutarate in Drosophila.Mutant IDH is sufficient to initiate enchondromatosis in mice.Smyd1 facilitates heart development by antagonizing oxidative and ER stress responses.Mutant IDH1 Dysregulates the Differentiation of Mesenchymal Stem Cells in Association with Gene-Specific Histone Modifications to Cartilage- and Bone-Related Genes.IDH1R132H in Neural Stem Cells: Differentiation Impaired by Increased Apoptosis.TET proteins and 5-methylcytosine oxidation in hematological cancers IDH1 R132H Mutation Enhances Cell Migration by Activating AKT-mTOR Signaling Pathway, but Sensitizes Cells to 5-FU Treatment as NADPH and GSH Are Reduced.Mitochondrial Citrate Transporter-dependent Metabolic Signature in the 22q11.2 Deletion Syndrome Idh1 protects murine hepatocytes from endotoxin-induced oxidative stress by regulating the intracellular NADP(+)/NADPH ratio.Isocitrate dehydrogenase mutations in gliomas The potential for isocitrate dehydrogenase mutations to produce 2-hydroxyglutarate depends on allele specificity and subcellular compartmentalization.Understanding metabolic regulation and its influence on cell physiology Genetic, epigenetic, and molecular landscapes of multifocal and multicentric glioblastoma.What do we know about IDH1/2 mutations so far, and how do we use it?Molecular Pathways: Isocitrate Dehydrogenase Mutations in Cancer.What a difference a hydroxyl makes: mutant IDH, (R)-2-hydroxyglutarate, and cancer.IDH1 mutations alter citric acid cycle metabolism and increase dependence on oxidative mitochondrial metabolism BCAT1 promotes cell proliferation through amino acid catabolism in gliomas carrying wild-type IDH1.Induction of sarcomas by mutant IDH2 The oncometabolite R-2-hydroxyglutarate activates NF-κB-dependent tumor-promoting stromal niche for acute myeloid leukemia cells.Complex role of HIF in cancer: the known, the unknown, and the unexpected.Expression of Idh1(R132H) in the Murine Subventricular Zone Stem Cell Niche Recapitulates Features of Early Gliomagenesis.

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P2860

D-2-hydroxyglutarate produced by mutant IDH1 perturbs collagen maturation and basement membrane function.

http://www.wikidata.org/entity/Q36240913

description

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D-2-hydroxyglutarate produced ...... nd basement membrane function.

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D-2-hydroxyglutarate produced ...... nd basement membrane function.

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D-2-hydroxyglutarate produced ...... nd basement membrane function.

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D-2-hydroxyglutarate produced ...... nd basement membrane function.

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Andrew J Elia

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Andrew Wakeham

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Anjana Rao

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Annick You Ten

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Bryan Snow

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Christiane B Knobbe

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Iok In Christine Chio

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Isaac S Harris

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Jillian Haight

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Katharine E Yen

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P2860

The human PICD gene encodes a cytoplasmic and peroxisomal NADP(+)-dependent isocitrate dehydrogenase

Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate

Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma

Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketoglutarate-dependent dioxygenases

Recurring mutations found by sequencing an acute myeloid leukemia genome

An integrated genomic analysis of human glioblastoma multiforme

IDH1 and IDH2 mutations in gliomas

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

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2038-2049

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10.1101/GAD.198200.112

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18

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26

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