D-2-hydroxyglutarate produced by mutant IDH1 perturbs collagen maturation and basement membrane function.
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Molecular Imaging of Metabolic Reprograming in Mutant IDH CellsEpigenetic regulators and their impact on therapy in acute myeloid leukemiaNew developments in the pathogenesis and therapeutic targeting of the IDH1 mutation in gliomaIDH1/2 mutations target a key hallmark of cancer by deregulating cellular metabolism in gliomaIsocitrate dehydrogenase mutations: new opportunities for translational researchContemporary murine models in preclinical astrocytoma drug developmentIDH mutations in tumorigenesis and their potential role as novel therapeutic targets.An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells.Metabolic consequences of oncogenic IDH mutations2-Hydoxyglutarate: D/Riving Pathology in gLiomaSIDH1 regulates phospholipid metabolism in developing astrocytesIn vitro visualization and characterization of wild type and mutant IDH homo- and heterodimers using Bimolecular Fluorescence Complementation.Hominoid-specific enzyme GLUD2 promotes growth of IDH1R132H gliomaMutations in CIC and IDH1 cooperatively regulate 2-hydroxyglutarate levels and cell clonogenicityOncometabolites: linking altered metabolism with cancer.Genomic insights into cancer-associated aberrant CpG island hypermethylationGlial progenitors as targets for transformation in glioma.The emerging nexus of active DNA demethylation and mitochondrial oxidative metabolism in post-mitotic neuronsGenetic dissection of leukemia-associated IDH1 and IDH2 mutants and D-2-hydroxyglutarate in Drosophila.Mutant IDH is sufficient to initiate enchondromatosis in mice.Smyd1 facilitates heart development by antagonizing oxidative and ER stress responses.Mutant IDH1 Dysregulates the Differentiation of Mesenchymal Stem Cells in Association with Gene-Specific Histone Modifications to Cartilage- and Bone-Related Genes.IDH1R132H in Neural Stem Cells: Differentiation Impaired by Increased Apoptosis.TET proteins and 5-methylcytosine oxidation in hematological cancersIDH1 R132H Mutation Enhances Cell Migration by Activating AKT-mTOR Signaling Pathway, but Sensitizes Cells to 5-FU Treatment as NADPH and GSH Are Reduced.Mitochondrial Citrate Transporter-dependent Metabolic Signature in the 22q11.2 Deletion SyndromeIdh1 protects murine hepatocytes from endotoxin-induced oxidative stress by regulating the intracellular NADP(+)/NADPH ratio.Isocitrate dehydrogenase mutations in gliomasThe potential for isocitrate dehydrogenase mutations to produce 2-hydroxyglutarate depends on allele specificity and subcellular compartmentalization.Understanding metabolic regulation and its influence on cell physiologyGenetic, epigenetic, and molecular landscapes of multifocal and multicentric glioblastoma.What do we know about IDH1/2 mutations so far, and how do we use it?Molecular Pathways: Isocitrate Dehydrogenase Mutations in Cancer.What a difference a hydroxyl makes: mutant IDH, (R)-2-hydroxyglutarate, and cancer.IDH1 mutations alter citric acid cycle metabolism and increase dependence on oxidative mitochondrial metabolismBCAT1 promotes cell proliferation through amino acid catabolism in gliomas carrying wild-type IDH1.Induction of sarcomas by mutant IDH2The oncometabolite R-2-hydroxyglutarate activates NF-κB-dependent tumor-promoting stromal niche for acute myeloid leukemia cells.Complex role of HIF in cancer: the known, the unknown, and the unexpected.Expression of Idh1(R132H) in the Murine Subventricular Zone Stem Cell Niche Recapitulates Features of Early Gliomagenesis.
P2860
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P2860
D-2-hydroxyglutarate produced by mutant IDH1 perturbs collagen maturation and basement membrane function.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年論文
@yue
2012年論文
@zh-hant
2012年論文
@zh-hk
2012年論文
@zh-mo
2012年論文
@zh-tw
2012年论文
@wuu
2012年论文
@zh
2012年论文
@zh-cn
name
D-2-hydroxyglutarate produced ...... nd basement membrane function.
@ast
D-2-hydroxyglutarate produced ...... nd basement membrane function.
@en
type
label
D-2-hydroxyglutarate produced ...... nd basement membrane function.
@ast
D-2-hydroxyglutarate produced ...... nd basement membrane function.
@en
prefLabel
D-2-hydroxyglutarate produced ...... nd basement membrane function.
@ast
D-2-hydroxyglutarate produced ...... nd basement membrane function.
@en
P2093
P2860
P356
P1433
P1476
D-2-hydroxyglutarate produced ...... nd basement membrane function.
@en
P2093
Andrew J Elia
Andrew Wakeham
Anjana Rao
Annick You Ten
Bryan Snow
Christiane B Knobbe
Iok In Christine Chio
Isaac S Harris
Jillian Haight
Katharine E Yen
P2860
P304
P356
10.1101/GAD.198200.112
P577
2012-08-27T00:00:00Z